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Lotrimin AF Lotion


Pronunciation: kloe-TRIM-uh-zole
Generic Name: Clotrimazole
Brand Name: Lotrimin AF
Lotrimin AF Lotion is used for:

Treating athlete's foot, jock itch, and ringworm. It may also be used for other conditions as determined by your doctor.

Lotrimin AF Lotion is an antifungal agent. It kills sensitive fungi by binding to the fungal cell membrane and weakening it. This allows the cell contents to leak out and results in the death of the fungus.

Do NOT use Lotrimin AF Lotion if: you are allergic to any ingredient in Lotrimin AF Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lotrimin AF Lotion:

Some medical conditions may interact with Lotrimin AF Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Lotrimin AF Lotion. Because little, if any, of Lotrimin AF Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Lotrimin AF Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lotrimin AF Lotion:

Use Lotrimin AF Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Lotrimin AF Lotion is for topical use on the skin only. Clean the affected area with soap and water and dry thoroughly. Shake well before each use. Apply a thin layer of medicine to the affected area. Rub it in gently. Do not cover unless directed to by your doctor. Wash your hands immediately after using Lotrimin AF Lotion, unless your hands are part of the treated area. To clear up your infection completely, use Lotrimin AF Lotion for the full course of treatment. Keep using it even if you feel better in a few days. Do not miss any doses. If you miss a dose of Lotrimin AF Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Lotrimin AF Lotion.

Important safety information: Lotrimin AF Lotion is for external use only. If you get Lotrimin AF Lotion in your eyes, immediately flush them with cool tap water. Be sure to use Lotrimin AF Lotion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lotrimin AF Lotion while you are pregnant. It is not known if Lotrimin AF Lotion is found in breast milk. If you are or will be breast-feeding while you use Lotrimin AF Lotion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Lotrimin AF Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); reddening, blistering, peeling, itching, or burning of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lotrimin AF side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Lotrimin AF Lotion may be harmful if swallowed.

Proper storage of Lotrimin AF Lotion:

Store Lotrimin AF Lotion at room temperature, 59 to 86 degrees F (15 to 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lotrimin AF Lotion out of the reach of children and away from pets.

General information: If you have any questions about Lotrimin AF Lotion, please talk with your doctor, pharmacist, or other health care provider. Lotrimin AF Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lotrimin AF Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Lotrimin AF resources Lotrimin AF Side Effects (in more detail) Lotrimin AF Use in Pregnancy & Breastfeeding Lotrimin AF Support Group 0 Reviews for Lotrimin AF - Add your own review/rating Compare Lotrimin AF with other medications Tinea Corporis Tinea Pedis
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Lactinol Lotion


Pronunciation: LACK-tick ASS-id
Generic Name: Lactic Acid
Brand Name: Examples include Lac-Hydrin and Lactinol
Lactinol Lotion is used for:

Moisturizing and softening dry, scaly skin (xerosis) and ichthyosis vulgaris, and for the temporary relief of itching associated with these conditions.

Lactinol Lotion is a humectant. Exactly how it works is unknown but it increases the amount of water in the skin, making it softer and more pliable.

Do NOT use Lactinol Lotion if: you are allergic to any ingredient in Lactinol Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lactinol Lotion:

Some medical conditions may interact with Lactinol Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Lactinol Lotion. Because little, if any, of Lactinol Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lactinol Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lactinol Lotion:

Use Lactinol Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Apply Lactinol Lotion to the affected area and rub in thoroughly twice daily or as directed by your health care provider. Wash your hands immediately after using Lactinol Lotion, unless your hands are part of the treated area. If you miss a dose of Lactinol Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Lactinol Lotion.

Important safety information: Lactinol Lotion may cause stinging or burning when applied to cracked or scraped skin (eg, after shaving). Lactinol Lotion is for external use only. Avoid contact with the eyes, lips, or mucous membranes. Lactinol Lotion may cause irritation. Use caution when applying Lactinol Lotion to the face. Lactinol Lotion may be harmful if swallowed. If you or someone you know may have taken Lactinol Lotion by mouth, contact your local poison control center or emergency room immediately. Overuse of topical products may worsen your condition. Lactinol Lotion may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Lactinol Lotion. Use a sunscreen or protective clothing if you must be outside for a prolonged period. PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Lactinol Lotion during pregnancy. It is unknown if Lactinol Lotion is excreted in breast milk. If you are or will be breast-feeding while you are using Lactinol Lotion, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects of Lactinol Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild, temporary burning, irritation, peeling, redness, sensitivity, or stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or prolonged burning, peeling, redness, stinging, sensitivity, or irritation; worsening of condition.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lactinol side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Lactinol Lotion may be harmful if swallowed.

Proper storage of Lactinol Lotion:

Store Lactinol Lotion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Keep Lactinol Lotion out of the reach of children and away from pets.

General information: If you have any questions about Lactinol Lotion, please talk with your doctor, pharmacist, or other health care provider. Lactinol Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lactinol Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Lactinol resources Lactinol Side Effects (in more detail) Lactinol Use in Pregnancy & Breastfeeding Lactinol Support Group 0 Reviews for Lactinol - Add your own review/rating Compare Lactinol with other medications Dry Skin Pityriasis rubra pilaris
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Clotrimazole Lotion


Pronunciation: kloe-TRIM-uh-zole
Generic Name: Clotrimazole
Brand Name: Lotrimin AF
Clotrimazole Lotion is used for:

Treating athlete's foot, jock itch, and ringworm. It may also be used for other conditions as determined by your doctor.

Clotrimazole Lotion is an antifungal agent. It kills sensitive fungi by binding to the fungal cell membrane and weakening it. This allows the cell contents to leak out and results in the death of the fungus.

Do NOT use Clotrimazole Lotion if: you are allergic to any ingredient in Clotrimazole Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clotrimazole Lotion:

Some medical conditions may interact with Clotrimazole Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Clotrimazole Lotion. Because little, if any, of Clotrimazole Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Clotrimazole Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clotrimazole Lotion:

Use Clotrimazole Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Clotrimazole Lotion is for topical use on the skin only. Clean the affected area with soap and water and dry thoroughly. Shake well before each use. Apply a thin layer of medicine to the affected area. Rub it in gently. Do not cover unless directed to by your doctor. Wash your hands immediately after using Clotrimazole Lotion, unless your hands are part of the treated area. To clear up your infection completely, use Clotrimazole Lotion for the full course of treatment. Keep using it even if you feel better in a few days. Do not miss any doses. If you miss a dose of Clotrimazole Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Clotrimazole Lotion.

Important safety information: Clotrimazole Lotion is for external use only. If you get Clotrimazole Lotion in your eyes, immediately flush them with cool tap water. Be sure to use Clotrimazole Lotion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clotrimazole Lotion while you are pregnant. It is not known if Clotrimazole Lotion is found in breast milk. If you are or will be breast-feeding while you use Clotrimazole Lotion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Clotrimazole Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); reddening, blistering, peeling, itching, or burning of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Clotrimazole Lotion may be harmful if swallowed.

Proper storage of Clotrimazole Lotion:

Store Clotrimazole Lotion at room temperature, 59 to 86 degrees F (15 to 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clotrimazole Lotion out of the reach of children and away from pets.

General information: If you have any questions about Clotrimazole Lotion, please talk with your doctor, pharmacist, or other health care provider. Clotrimazole Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Clotrimazole Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Clotrimazole resources Clotrimazole Use in Pregnancy & BreastfeedingClotrimazole Support Group2 Reviews for Clotrimazole - Add your own review/rating Compare Clotrimazole with other medications Cutaneous CandidiasisTinea CorporisTinea CrurisTinea PedisTinea VersicolorVaginal Yeast Infection
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Selenium Lotion


Pronunciation: se-LEE-nee-um
Generic Name: Selenium
Brand Name: Examples include Dandrex and Selsun Blue
Selenium Lotion is used for:

Treating dandruff and other conditions of the scalp and skin.

Selenium Lotion is a cytostatic agent. It works by reducing skin cell growth and inhibiting growth of organisms associated with chronic flaking and itching.

Do NOT use Selenium Lotion if: you are allergic to any ingredient in Selenium Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Selenium Lotion:

Some medical conditions may interact with Selenium Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Selenium Lotion. Because little, if any, of Selenium Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Selenium Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Selenium Lotion:

Use Selenium Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Shake well before each use. Remove jewelry before using Selenium Lotion. Do not use on broken or inflamed skin or scalp. To use Selenium Lotion on the scalp - Massage 1 or 2 teaspoonfuls of the medicine on the wet scalp. Leave on the scalp for 2 to 3 minutes. Rinse scalp thoroughly. Wash hands well after treatment. If you are using Selenium Lotion before or after bleaching, tinting, or permanent waving of hair, rinse hair for at least 5 minutes in cool running water. To use Selenium Lotion on the skin - Apply a sufficient amount to cover affected areas of the body. Lather well with a small amount of water. Leave the medicine on the skin for 10 minutes. Rinse thoroughly in the shower. Wash hands well after treatment. If you miss a dose of Selenium Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once

Ask your health care provider any questions you may have about how to use Selenium Lotion.

Important safety information: If your symptoms do not get better within 1 to 2 weeks or if they get worse, check with your doctor. Do NOT use for longer than prescribed without checking with your doctor. Do not get Selenium Lotion in your eyes, or on the inside of your nose or mouth. Do not use Selenium Lotion on broken or blistered skin. Do not apply Selenium Lotion to the genital area. If you get Selenium Lotion on your genitals, rinse thoroughly with water. Selenium Lotion may damage jewelry. Remove jewelry before using Selenium Lotion. Selenium Lotion should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Selenium Lotion while you are pregnant. It is not known if Selenium Lotion is found in breast milk. Do not breast-feed while taking Selenium Lotion. Possible side effects of Selenium Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Hair discoloration (minimized by thorough rinsing); increase in mild hair loss or thinning; oiliness or dryness of hair and scalp.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Selenium side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Selenium Lotion may be harmful if swallowed.

Proper storage of Selenium Lotion:

Store Selenium Lotion below 86 degrees F (30 degrees C) in a tightly closed container. Store away from heat and light. Keep Selenium Lotion out of the reach of children and away from pets.

General information: If you have any questions about Selenium Lotion, please talk with your doctor, pharmacist, or other health care provider. Selenium Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Selenium Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Selenium resources Selenium Side Effects (in more detail) Selenium Use in Pregnancy & Breastfeeding Selenium Support Group 3 Reviews for Selenium - Add your own review/rating Compare Selenium with other medications Seborrheic Dermatitis Tinea Versicolor
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Versiclear Lotion


Pronunciation: SOE-dee-um THYE-oh-SUL-fate/SAL-i SIL-ik AS-id
Generic Name: Sodium Thiosulfate
Brand Name: Versiclear Lotion
Versiclear Lotion is used for:

Treating tinea versicolor, a fungal infection of the skin.

Versiclear Lotion is a topical antifungal and keratolytic agent. It works by killing the fungus that causes tinea versicolor. The keratolytic helps the antifungal reach the deep layers of the skin.

Do NOT use Versiclear Lotion if: you are allergic to any ingredient in Versiclear Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Versiclear Lotion:

Some medical conditions may interact with Versiclear Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have cut, scraped, irritated, or damaged skin at the application site

Some MEDICINES MAY INTERACT with Versiclear Lotion. Because little, if any, of Versiclear Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Versiclear Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Versiclear Lotion:

Use Versiclear Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Shake well before each use. Wash your hands thoroughly before and after using Versiclear Lotion, unless your hands are part of the treated area. Wash, rinse, and dry the affected area before you apply Versiclear Lotion. Apply a thin film of Versiclear Lotion to all affected areas as directed by your health care provider. Do not bandage or wrap the affected area unless directed otherwise by your doctor. To clear up your infection completely, use Versiclear Lotion for the full course of treatment. Keep using it even if your symptoms improve in a few days. If you miss a dose of Versiclear Lotion, use it as soon as you remember. Continue to use it as directed by your doctor or the package label.

Ask your health care provider any questions you may have about how to use Versiclear Lotion.

Important safety information: Versiclear Lotion may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away. Do not use Versiclear Lotion on or around the eyes. If you get Versiclear Lotion in your eyes, immediately flush with cool tap water. If you use topical products too often, your condition may become worse. Talk with your doctor before you use any other medicines or cleansers on your skin. Be sure to use Versiclear Lotion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. If your symptoms do not get better or if they get worse, check with your doctor. Versiclear Lotion should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Versiclear Lotion while you are pregnant. It is not known if Versiclear Lotion is found in breast milk after topical use. If you are or will be breast-feeding while you use Versiclear Lotion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Versiclear Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild, temporary burning or stinging at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); new or worsening irritation, pain, redness, blistering, or severe burning at the application site.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

See also: Versiclear side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Versiclear Lotion:

Store Versiclear Lotion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Versiclear Lotion out of the reach of children and away from pets.

General information: If you have any questions about Versiclear Lotion, please talk with your doctor, pharmacist, or other health care provider. Versiclear Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Versiclear Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Versiclear resources Versiclear Side Effects (in more detail) Versiclear Use in Pregnancy & Breastfeeding Versiclear Drug Interactions Versiclear Support Group 0 Reviews for Versiclear - Add your own review/rating Compare Versiclear with other medications Tinea Versicolor
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Metrotop (Molnlycke Health Care )


1. Name Of The Medicinal Product

Metrotop.

2. Qualitative And Quantitative Composition

Metronidazole BP 0.8% w/v.

3. Pharmaceutical Form

A colourless aqueous gel.

4. Clinical Particulars 4.1 Therapeutic Indications

For the treatment of malodorous fungating tumours, gravitational ulcers and decubitus ulcers (pressure sores).

4.2 Posology And Method Of Administration

For external use only. Adults: All wounds should be cleaned thoroughly. Flat wounds require a liberal application of the gel over the complete area. Cavities should be loosely packed with paraffin gauze which has been smeared in the gel. All wounds should be covered with a non-adherent dressing and a pad of lint or gauze. Sticking may occur if the appropriate dressing is not used. Use once or twice daily as necessary. Elderly: No specific instructions. Children: Where necessary, instructions apply as for adults.

4.3 Contraindications

Known hypersensitivity to metronidazole.

4.4 Special Warnings And Precautions For Use

The following statements take into account the possibility that metronidazole may be absorbed after topical application. However, there is no evidence of any significant systemic concentrations of metronidazole following topical applications. Peripheral neuropathy has been reported in association with prolonged use of metronidazole. The elimination half-life of metronidazole remains unchanged in the presence of renal failure. Such patients, however, retain the metabolite of metronidazole. The clinical significance of this is not known at present. However, in patients undergoing dialysis, metronidazole and metabolites are efficiently removed.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Some potentiation of anticoagulant therapy has been reported when metronidazole has been used with the warfarin type oral anticoagulants. Patients receiving phenobarbitone metabolise metronidazole at a much faster rate than normal, reducing the half-life to approximately 3 hours. Patients are advised not to take alcohol during systemic metronidazole therapy because of the possibility of a disulfiram-like reaction.

4.6 Pregnancy And Lactation

There is inadequate evidence of the use of metronidazole in pregnancy. Metronidazole gel cannot therefore be recommended during pregnancy or lactation where significant systemic absorption may occur unless the physician considers it essential.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

No adverse effects have been reported. Systemic metronidazole therapy may occasionally cause an unpleasant taste in the mouth, furred tongue, nausea, vomiting, gastrointestinal disturbance, urticaria, angioedema and anaphylaxis. Drowsiness, dizziness, headache, ataxia, skin rash, pruritus, and darkening of the urine have been reported, but rarely.

4.9 Overdose

There is no specific treatment for gross overdosage of metronidazole. Gastric lavage is recommended in cases of accidental ingestion. Uneventful recovery has followed overdosage of up to 12g taken orally. Metronidazole is readily removed from the plasma by dialysis.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Metronidazole is a potent agent against the anaerobic bacteria which are believed to produce odorous metabolites as a result of localised tissue colonisation. The aim of the product is to provide a high concentration of metronidazole at and around the site of colonisation in a water-miscible base. This form allows surface spread and penetration within the wound accompanied by ease of aseptic application and up to 24 hours duration of action.

5.2 Pharmacokinetic Properties

There is presently no evidence of any systemic concentrations of metronidazole following topical application.

5.3 Preclinical Safety Data

No further data given.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Hypromellose (4500); benzalkonium chloride solution; purified water.

6.2 Incompatibilities

None known.

6.3 Shelf Life

The shelf life shall not exceed 24 months from the date of manufacture.

6.4 Special Precautions For Storage

Do not store above 25°C. Once opened the contents should be used within 28 days of opening.

6.5 Nature And Contents Of Container

Polypropylene tubes each fitted with a plastic screw cap and tamper-evident seal and enclosed within a printed cardboard carton. Single tubes may sometimes be supplied without a carton. Pack sizes: The 15g, 30g and 60g tubes are available singly or in boxes of 12.

6.6 Special Precautions For Disposal And Other Handling

None given.

7. Marketing Authorisation Holder

Medlock Medical Limited, Tubiton House, Medlock Street, Oldham, OL1 3HS.

8. Marketing Authorisation Number(S)

PL 21248/0040.

9. Date Of First Authorisation/Renewal Of The Authorisation

16th September 2005.

10. Date Of Revision Of The Text

September 2005.


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MetroGel-Vaginal


Generic Name: metronidazole vaginal (MET roe NYE da zole)
Brand Names: MetroGel-Vaginal, Vandazole

What is MetroGel-Vaginal (metronidazole vaginal)?

Metronidazole is an antibiotic that fights bacteria in the body.

Metronidazole vaginal is used to treat vaginal infections caused by bacteria.

Metronidazole vaginal may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about MetroGel-Vaginal (metronidazole vaginal)?

Do not use metronidazole vaginal if you have ever had an allergic reaction to it.

Before using metronidazole vaginal, tell your doctor if you have liver disease, a seizure disorder, problems with circulation (such as Raynaud's syndrome), or if you have taken disulfiram (Antabuse) within the past 14 days.

Avoid having sex until your vaginal infection has been completely treated and you have finished using the medication.

Avoid using other vaginal creams or douches at the same time as metronidazole vaginal unless your doctor approves.

Use metronidazole vaginal for the entire length of time prescribed by your doctor, even during your menstrual period. Your symptoms may get better before the infection is completely treated. If the infection does not clear up after you have finished one course of therapy, or if your symptoms get worse, see your doctor. You may have another type of infection that metronidazole will not treat. What should I discuss with my doctor before using MetroGel-Vaginal (metronidazole vaginal)?

Do not use metronidazole vaginal if you have ever had an allergic reaction to it.

Before using metronidazole vaginal, tell your doctor if you are allergic to any drugs, or if you have:

liver disease;

a seizure disorder; or

problems with circulation (such as Raynaud's syndrome).

If you have any of these conditions, you may need a dose adjustment or special tests to safely use metronidazole vaginal.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Metronidazole vaginal may pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I use MetroGel-Vaginal (metronidazole vaginal)?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.

Wash your hands before and after using this medication.

Insert the cream into your vagina using the applicator as directed.

Your medication may come with disposable applicators. Use each applicator for only 1 day and then throw it away. If you use the medication twice daily, wash and rinse the applicator after your morning dose and use it again for your evening dose. Then throw it away and use a new applicator the next day.

Use metronidazole vaginal for the entire length of time prescribed by your doctor, even during your menstrual period. Your symptoms may get better before the infection is completely treated.

If the infection does not clear up after you have finished one course of therapy, or if your symptoms get worse, see your doctor. You may have another type of infection that metronidazole will not treat.

You may need to use a sanitary napkin during treatment, but do not use a tampon.

Metronidazole vaginal can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using this medication.

Store metronidazole vaginal at room temperature away from moisture or heat. Do not allow it to freeze. What happens if I miss a dose?

Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of metronidazole applied in the vagina is not expected to produce life-threatening symptoms.

What should I avoid while using MetroGel-Vaginal (metronidazole vaginal)? Avoid getting this medication in your eyes, nose, or mouth. If it does get into any of these areas, rinse with plenty of cool water.

Avoid wearing tight-fitting, synthetic clothing such as nylon underwear or panty hose that does not allow air circulation. Wear loose-fitting clothing made of cotton and other natural fibers until your infection is healed.

Avoid having sex until your vaginal infection has been completely treated and you have finished using the medication.

Avoid using other vaginal creams or douches at the same time as metronidazole vaginal unless your doctor approves.

Avoid drinking alcohol while you are using metronidazole vaginal. MetroGel-Vaginal (metronidazole vaginal) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Rare but serious side effects may include:

seizure (convulsions); or

numbness, burning, pain, or tingly feeling in your hands or feet.

Less serious side effects may include:

mild burning or stinging when the medication is applied;

pelvic pain or cramps;

loss of appetite, constipation, upset stomach, vomiting;

dizziness, sleep problems (insomnia);

runny nose;

urinating more than usual;

acne, increased sweating; or

breast discharge or enlargement.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect MetroGel-Vaginal (metronidazole vaginal)?

Tell your doctor if you have taken disulfiram (Antabuse) within the past 14 days. Also tell your doctor if you are using:

cimetidine (Tagamet);

lithium (Eskalith, Lithobid, Lithonate); or

a blood thinner such as warfarin (Coumadin).

There may be other drugs that can interact with metronidazole vaginal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More MetroGel-Vaginal resources MetroGel-Vaginal Side Effects (in more detail) MetroGel-Vaginal Use in Pregnancy & Breastfeeding MetroGel-Vaginal Drug Interactions MetroGel-Vaginal Support Group 3 Reviews for MetroGel-Vaginal - Add your own review/rating MetroCream Cream MedFacts Consumer Leaflet (Wolters Kluwer) MetroCream Prescribing Information (FDA) MetroGel Prescribing Information (FDA) Metrocream Metrocream Topical Advanced Consumer (Micromedex) - Includes Dosage Information Metrogel-Vaginal Advanced Consumer (Micromedex) - Includes Dosage Information Metrolotion Noritate Prescribing Information (FDA) Rozex Emulsion MedFacts Consumer Leaflet (Wolters Kluwer) Vandazole Prescribing Information (FDA) Vitazol Prescribing Information (FDA) Compare MetroGel-Vaginal with other medications Bacterial Vaginitis Where can I get more information? Your pharmacist can provide more information about metronidazole vaginal.

See also: MetroGel-Vaginal side effects (in more detail)


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Kenalog Lotion


Pronunciation: trye-am-SIN-oh-lone
Generic Name: Triamcinolone
Brand Name: Kenalog
Kenalog Lotion is used for:

Reducing itching, redness, and swelling associated with many skin conditions.

Kenalog Lotion is a corticosteroid. The exact way that it acts against most causes of inflammation is not known, but it is thought to slow or stop the chemicals in the body that cause inflammation, which helps relieve discomfort.

Do NOT use Kenalog Lotion if: you are allergic to any ingredient in Kenalog Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Kenalog Lotion:

Some medical conditions may interact with Kenalog Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a skin infection, measles, thinning of the skin, tuberculosis (TB), a positive TB skin test, chickenpox, shingles, or have recently had a vaccination

Some MEDICINES MAY INTERACT with Kenalog Lotion. Because little, if any, of Kenalog Lotion is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Kenalog Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Kenalog Lotion:

Use Kenalog Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Apply a small amount of medicine to the affected area. Gently rub the medicine in until it is evenly distributed. Wash your hands after applying Kenalog Lotion, unless your hands are part of the treated area. Shake well before each use. Do not wrap or otherwise cover the treated area with bandages or wear tight-fitting clothing unless specifically directed to do so by your doctor. Do not use tight-fitting diapers or plastic pants on children using Kenalog Lotion in the diaper area. If you miss a dose of Kenalog Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Kenalog Lotion.

Important safety information: Kenalog Lotion is for external use only. If you get Kenalog Lotion in your eyes, immediately flush with cool tap water. Do not use Kenalog Lotion for other skin conditions at a later time. Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Kenalog Lotion. Caution is advised when using Kenalog Lotion in CHILDREN; they may be more sensitive to its effects. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Kenalog Lotion while you are pregnant. It is not known if Kenalog Lotion is found in breast milk after topical use. If you are or will be breast-feeding while you use Kenalog Lotion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Kenalog Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no COMMON side effects have been reported with this product. Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision;changes in menstrual cycle; easy bruising; excessive hair growth; impaired wound healing; itching, burning, redness, discoloration, or swelling of the skin not present before using Kenalog Lotion; mental or mood changes; moon face; muscle weakness; osteoporosis; rise in body temperature; skin thinning; tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Kenalog side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Kenalog Lotion may be harmful if swallowed.

Proper storage of Kenalog Lotion:

Store Kenalog Lotion at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Kenalog Lotion out of the reach of children and away from pets.

General information: If you have any questions about Kenalog Lotion, please talk with your doctor, pharmacist, or other health care provider. Kenalog Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Kenalog Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Kenalog resources Kenalog Side Effects (in more detail) Kenalog Use in Pregnancy & Breastfeeding Kenalog Drug Interactions Kenalog Support Group 6 Reviews for Kenalog - Add your own review/rating Compare Kenalog with other medications Atopic Dermatitis Dermatitis Lichen Planus Psoriasis
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Adapalene Lotion


Pronunciation: a-DAP-a-leen
Generic Name: Adapalene
Brand Name: Differin
Adapalene Lotion is used for:

Treating severe acne. It may also be used for other conditions as determined by your doctor.

Adapalene Lotion is a retinoid-like compound. Exactly how it works is not known. However, it helps the skin cells renew quicker and decreases blackhead formation.

Do NOT use Adapalene Lotion if: you are allergic to any ingredient in Adapalene Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Adapalene Lotion:

Some medical conditions may interact with Adapalene Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have eczema or sunburn

Some MEDICINES MAY INTERACT with Adapalene Lotion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Products that contain resorcinol, salicylic acid, or sulfur because the risk of skin irritation may be increased

Ask your health care provider if Adapalene Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Adapalene Lotion:

Use Adapalene Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Adapalene Lotion is for external use only. Avoid contact with the eyes, lips, angles of the nose, and mucous membranes. Exposure of Adapalene Lotion to the eye may cause swelling, redness, and irritation. Do not apply Adapalene Lotion to cuts, damaged or sunburned skin, or eczema. Use Adapalene Lotion in the evening before bedtime unless directed otherwise by your doctor. Before applying Adapalene Lotion, clean the area to be treated with mild soap or soapless cleanser and gently dry. Apply a thin film of Adapalene Lotion to the entire face and other affected areas, as directed by your doctor. Use an amount about the size of a nickel (3 to 4 pumps) to cover the entire face. Rub in gently. Wash your hands immediately after using Adapalene Lotion. A mild sensation of warmth or slight stinging may occur shortly after using Adapalene Lotion. If you miss a dose of Adapalene Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once. If several applications are missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Adapalene Lotion.

Important safety information: Adapalene Lotion may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Adapalene Lotion. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. Do not use more than the recommended dose or more often than prescribed without checking with your doctor. Doing so will not make Adapalene Lotion work faster or better, but may increase the risk of skin irritation. Acne may worsen temporarily when you begin using Adapalene Lotion. This is normal and not a cause for concern. Continue to use Adapalene Lotion. If your condition does not improve within 12 weeks, check with your doctor. Do not use other medicines or skin products on the affected area without first checking with your doctor. Some other products may increase the risk of skin irritation. Skin moisturizers may be used if necessary. Do not use moisturizers that contain alpha hydroxy or glycolic acids. Certain cosmetic procedures, such as waxing, should not be performed on treated skin because of possible irritation. Cosmetics may be used while using Adapalene Lotion. After using cosmetics, thoroughly wash and dry the affected area before applying Adapalene Lotion. Wind and cold temperatures can also irritate the affected skin. Adapalene Lotion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Adapalene Lotion while you are pregnant. It is not known if Adapalene Lotion is found in breast milk. If you are or will be breast-feeding while you use Adapalene Lotion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Adapalene Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; feeling of warmth; irritation; itching; peeling; redness; scaling; temporary burning and stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering; crusting; excessive redness or peeling; swelling.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Adapalene side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Adapalene Lotion may be harmful if swallowed.

Proper storage of Adapalene Lotion:

Store Adapalene Lotion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat and light. Do not freeze or refrigerate. Keep Adapalene Lotion out of the reach of children and away from pets.

General information: If you have any questions about Adapalene Lotion, please talk with your doctor, pharmacist, or other health care provider. Adapalene Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Adapalene Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Adapalene resources Adapalene Side Effects (in more detail) Adapalene Use in Pregnancy & Breastfeeding Adapalene Drug Interactions Adapalene Support Group 14 Reviews for Adapalene - Add your own review/rating Compare Adapalene with other medications Acne
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Vitazol Topical


Generic Name: metronidazole (Topical route)

met-roe-NYE-da-zole

Commonly used brand name(s)

In the U.S.

Metrocream Metrogel Metrolotion Noritate Rozex Vitazol

Available Dosage Forms:

Cream Lotion Gel/Jelly Emulsion

Therapeutic Class: Antiacne Antibacterial

Chemical Class: Nitroimidazole

Uses For Vitazol

Topical metronidazole is applied to the skin in adults to help control rosacea , also known as acne rosacea and “adult acne.” This medicine helps to reduce the redness of the skin and the number of pimples, usually found on the face, in patients with rosacea.

Topical metronidazole is available only with your doctor's prescription.

Before Using Vitazol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Rosacea is usually considered an adult disease. Therefore, topical metronidazole is not generally used in children.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of topical metronidazole in the elderly with use in other age groups.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Blood disease or a history of blood disease—Metronidazole may make the condition worse Proper Use of metronidazole

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Vitazol. Please read with care.

Do not use this medicine in or near the eyes. Watering of the eyes may occur when the medicine is used too close to the eyes.

If this medicine does get into your eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

Before applying this medicine, thoroughly wash the affected area(s) with a mild, nonirritating cleanser, rinse well, and gently pat dry.

To use:

After washing the affected area(s), apply this medicine with your fingertips. Apply and rub in a thin film of medicine, using enough to cover the affected area(s) lightly. You should apply the medicine to the whole area usually affected by rosacea, not just to the pimples themselves . Wash the medicine off your hands.

To help keep your rosacea under control, keep using this medicine for the full time of treatment. You may have to continue using this medicine every day for 9 weeks or longer. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage forms (cream, gel, and lotion): For rosacea: Adults—Apply to the affected area(s) of skin two times a day, morning and evening, for nine weeks. Children—Use and dose must be determined by your doctor. Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Vitazol

If your rosacea does not improve within 3 weeks, or if it becomes worse, check with your doctor. However, treatment of rosacea may take up to 9 weeks or longer before you see full improvement.

Stinging or burning of the skin may be expected after this medicine is applied. These effects may last up to a few minutes or more. If irritation continues, check with your doctor. You may have to use the medicine less often or stop using it altogether. Follow your doctor's directions.

You may continue to use cosmetics (make-up) while you are using this medicine for rosacea. However, it is best to use only “oil-free” cosmetics. Also, it is best not to use cosmetics too heavily or too often. They may make your rosacea worse. If you have any questions about this, check with your doctor.

Vitazol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common Dry skin redness or other signs of skin irritation not present before use of this medicine stinging or burning of the skin watering of eyes Rare Metallic taste in the mouth nausea tingling or numbness of arms, legs, hands, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Vitazol Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Vitazol Topical resources Vitazol Topical Side Effects (in more detail) Vitazol Topical Use in Pregnancy & Breastfeeding Vitazol Topical Drug Interactions Vitazol Topical Support Group 0 Reviews for Vitazol Topical - Add your own review/rating Compare Vitazol Topical with other medications Rosacea
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Metrolotion Topical


Generic Name: metronidazole (Topical route)

met-roe-NYE-da-zole

Commonly used brand name(s)

In the U.S.

Metrocream Metrogel Metrolotion Noritate Rozex Vitazol

Available Dosage Forms:

Cream Lotion Gel/Jelly Emulsion

Therapeutic Class: Antiacne Antibacterial

Chemical Class: Nitroimidazole

Uses For Metrolotion

Topical metronidazole is applied to the skin in adults to help control rosacea , also known as acne rosacea and “adult acne.” This medicine helps to reduce the redness of the skin and the number of pimples, usually found on the face, in patients with rosacea.

Topical metronidazole is available only with your doctor's prescription.

Before Using Metrolotion

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Rosacea is usually considered an adult disease. Therefore, topical metronidazole is not generally used in children.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of topical metronidazole in the elderly with use in other age groups.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Blood disease or a history of blood disease—Metronidazole may make the condition worse Proper Use of metronidazole

This section provides information on the proper use of a number of products that contain metronidazole. It may not be specific to Metrolotion. Please read with care.

Do not use this medicine in or near the eyes. Watering of the eyes may occur when the medicine is used too close to the eyes.

If this medicine does get into your eyes, wash them out immediately, but carefully, with large amounts of cool tap water. If your eyes still burn or are painful, check with your doctor.

Before applying this medicine, thoroughly wash the affected area(s) with a mild, nonirritating cleanser, rinse well, and gently pat dry.

To use:

After washing the affected area(s), apply this medicine with your fingertips. Apply and rub in a thin film of medicine, using enough to cover the affected area(s) lightly. You should apply the medicine to the whole area usually affected by rosacea, not just to the pimples themselves . Wash the medicine off your hands.

To help keep your rosacea under control, keep using this medicine for the full time of treatment. You may have to continue using this medicine every day for 9 weeks or longer. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage forms (cream, gel, and lotion): For rosacea: Adults—Apply to the affected area(s) of skin two times a day, morning and evening, for nine weeks. Children—Use and dose must be determined by your doctor. Missed Dose

If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Metrolotion

If your rosacea does not improve within 3 weeks, or if it becomes worse, check with your doctor. However, treatment of rosacea may take up to 9 weeks or longer before you see full improvement.

Stinging or burning of the skin may be expected after this medicine is applied. These effects may last up to a few minutes or more. If irritation continues, check with your doctor. You may have to use the medicine less often or stop using it altogether. Follow your doctor's directions.

You may continue to use cosmetics (make-up) while you are using this medicine for rosacea. However, it is best to use only “oil-free” cosmetics. Also, it is best not to use cosmetics too heavily or too often. They may make your rosacea worse. If you have any questions about this, check with your doctor.

Metrolotion Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common Dry skin redness or other signs of skin irritation not present before use of this medicine stinging or burning of the skin watering of eyes Rare Metallic taste in the mouth nausea tingling or numbness of arms, legs, hands, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Metrolotion Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Metrolotion Topical resources Metrolotion Topical Side Effects (in more detail) Metrolotion Topical Use in Pregnancy & Breastfeeding Metrolotion Topical Drug Interactions Metrolotion Topical Support Group 0 Reviews for Metrolotion Topical - Add your own review/rating Compare Metrolotion Topical with other medications Perioral Dermatitis Rosacea
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Sebizon Lotion


Pronunciation: sul-fa-SEE-ta-mide
Generic Name: Sulfacetamide
Brand Name: Seb-Prev and Sebizon
Sebizon Lotion is used for:

Treating bacterial infections of the skin, including dandruff. It may also be used for other conditions as determined by your doctor.

Sebizon Lotion is a sulfonamide. It works by restricting the production of folic acid, which bacteria need for growth. This kills the bacteria.

Do NOT use Sebizon Lotion if: you are allergic to any ingredient in Sebizon Lotion you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide

Contact your doctor or health care provider right away if any of these apply to you.

Before using Sebizon Lotion:

Some medical conditions may interact with Sebizon Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have asthma

Some MEDICINES MAY INTERACT with Sebizon Lotion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Silver-containing products (eg, silver sulfadiazine) because they may decrease Sebizon Lotion's effectiveness Methenamine because it may increase the risk of Sebizon Lotion's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sebizon Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Sebizon Lotion:

Use Sebizon Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Sebizon Lotion is for use on the skin only. Shake well before each use. Wash your hands before and after using Sebizon Lotion. Apply enough medicine to cover the affected area. Rub in gently. If your skin becomes too dry, apply less medicine to the affected area. To clear up your infection completely, use Sebizon Lotion for the full course of treatment. Keep using it even if you feel better in a few days. Sebizon Lotion works best if it is used at the same time each day. Continue to use Sebizon Lotion even if you feel well. Do not miss any doses. If you miss a dose of Sebizon Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Sebizon Lotion.

Important safety information: Avoid getting Sebizon Lotion in your eyes, nose, or mouth. Talk with your doctor before you use any other medicines or cleansers on your skin. Do not apply Sebizon Lotion over large areas of the body or to open wounds or scraped, infected, or burned skin without first checking with your doctor. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. Sebizon Lotion only works against bacteria; it does not treat viral infections. Be sure to use Sebizon Lotion for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Long-term or repeated use of Sebizon Lotion may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it. Large amounts of Sebizon Lotion may stain skin or white fabrics. This stain may be removed from fabric by ordinary laundering without bleach. Sebizon Lotion should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sebizon Lotion while you are pregnant. It is not known if Sebizon Lotion is found in breast milk after topical use. If you are or will be breast-feeding while you use Sebizon Lotion, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Sebizon Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild irritation.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; fever; joint pain; red, swollen, or blistered skin; severe diarrhea; severe or persistent irritation; sores in the mouth; stomach cramps/pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Sebizon side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Sebizon Lotion may be harmful if swallowed. Symptoms of ingestion may include change in the amount of urine; nausea; vomiting.

Proper storage of Sebizon Lotion:

Store Sebizon Lotion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not freeze. Keep Sebizon Lotion out of the reach of children and away from pets.

General information: If you have any questions about Sebizon Lotion, please talk with your doctor, pharmacist, or other health care provider. Sebizon Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Sebizon Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Sebizon resources Sebizon Side Effects (in more detail) Sebizon Use in Pregnancy & Breastfeeding Sebizon Support Group 0 Reviews for Sebizon - Add your own review/rating Compare Sebizon with other medications Seborrheic Dermatitis Secondary Cutaneous Bacterial Infections
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Metronidazole topical


Class: Antibacterials
VA Class: DE101
Chemical Name: 2-Methyl-5-nitro-1H-imidazole-1-ethanol
Molecular Formula: C6H9N3O3
CAS Number: 443-48-1
Brands: MetroCream, MetroGel, MetroGel-Vaginal, MetroLotion, Noritate, Vandazole

Introduction

Antibacterial and antiprotozoal;1 2 27 29 47 183 also has anti-inflammatory and immunosuppressive effects;1 2 14 17 21 28 180 nitroimidazole derivative.3

Uses for Metronidazole Rosacea

Treatment of inflammatory lesions (papules and pustules) associated with rosacea (acne rosacea);1 2 8 9 10 16 17 18 19 20 21 47 180 184 207 topical gel designated an orphan drug by FDA for use in this condition.23

Has no beneficial effects on telangiectasia,2 9 10 17 19 21 47 rhinophyma,47 or ocular manifestations of rosacea.47 83

Optimal treatment not determined; inflammatory lesions may respond to long-term treatment with topical anti-infectives (e.g., metronidazole) or oral anti-infectives (e.g., doxycycline, tetracycline, erythromycin, ampicillin, metronidazole).10 11 12 13 15 16 17 20 21 47 80 82 2 8 9 10 16 17 18 19 20 21 47 80 81 82 Topical metronidazole may be preferred to oral metronidazole;17 147 has been effective in patients with inadequate response or relapse with other therapies (e.g., oral tetracycline).2 10 17 21 62

Effects appear palliative;17 18 19 47 81 61 99 manifestations recur commonly following discontinuance of therapy.17 18 19 47 61 99

Adjunctive measures recommended to decrease exposure to factors that exacerbate rosacea (e.g., excessive sunlight, wind, hot liquids, spicy food, alcohol, extremes of heat and cold).2 12 80

Bacterial Vaginosis

Treatment of bacterial vaginosis (formerly called Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, anaerobic vaginosis)109 111 112 114 115 119 120 122 123 139 153 183 214 in nonpregnant women.214

CDC recommends treatment of bacterial vaginosis in all symptomatic women (including pregnant women).109 In addition, asymptomatic pregnant women at high risk for complications of pregnancy should be screened (preferably at the first prenatal visit) and treatment initiated if needed.109

Treatment recommendations for bacterial vaginosis in HIV-infected women are the same as those for women without HIV infection.109

Regimens of choice in nonpregnant women are a 7-day regimen of oral metronidazole, a 5-day regimen of intravaginal metronidazole gel, or a 7-day regimen of intravaginal clindamycin cream;109 114 alternative regimens are a 7-day regimen of oral clindamycin or 3-day regimen of intravaginal clindamycin suppositories.109 114 The preferred regimens for pregnant women are a 7-day regimen of oral metronidazole or a 7-day regimen of oral clindamycin.109

Regardless of regimen used, relapse or recurrence is common;109 110 120 122 138 153 162 an alternative regimen (e.g., oral therapy when topical was used initially) may be used in such situations.109 122

Routine treatment of asymptomatic male sexual contacts of women who have relapsing or recurrent bacterial vaginosis not recommended.109 113 201 202 203

Decubitus and Other Ulcers

Treatment of infected decubitus ulcers†;27 39 40 41 42 212 topical metronidazole designated an orphan drug by FDA for use in treatment of grade III or IV, anaerobically infected, decubitus ulcers.23

Perioral Dermatitis

Treatment of perioral dermatitis†;210 211 topical gel designated an orphan drug by FDA for treatment of this condition.23

Trichomoniasis

Has been used intravaginally as an adjunct to oral metronidazole for treatment of trichomoniasis caused by Trichomonas vaginalis† in selected cases (e.g., refractory infections),156 205 but not included in CDC recommendations for treatment of trichomoniasis.109 Intravaginal metronidazole not effective used alone.114

Drug of choice for treatment of trichomoniasis is oral metronidazole or oral tinidazole.109 114 123 215 216

Metronidazole Dosage and Administration Administration

Administer topically to the skin2 180 184 207 or intravaginally183 214 in appropriate formulations.

Topical skin preparations (cream, gel, lotion) are for external use only and should not be used orally, intravaginally, or near or in eyes.1 177 180 184 207

Intravaginal preparations are for intravaginal administration only and should not be used orally, topically on the skin, or near or in eyes.183 214

Topical Administration

Apply topically to the skin as a 0.75 or 1% cream, 1% gel, or 0.75% lotion.1 19 180 184 207

Prior to topical application, wash affected area with mild, nonirritating cleanser.1 2 180 184 207 To minimize risk of local irritation, some clinicians suggest application be delayed until about 15–20 minutes after skin cleansing.99

Rub cream, gel, or lotion into affected area.1 19 180 184 207 Avoid contact with eyes.1 19 180 184 207

If irritation occurs at application site, reduce application frequency or discontinue.1 19 180 184 207

Cosmetics may be applied to skin after application of cream, gel, or lotion;1 47 180 184 207 allow lotion to dry ?5 minutes before applying cosmetics.207

Intravaginal Topical Administration

Administer intravaginally as a 0.75% gel using vaginal applicators provided by the manufacturers.183 214

If once-daily regimen used, administer dose at bedtime.183 214

If once-daily regimen used, use new vaginal applicator for each dose.214 If twice-daily regimen used, use new applicator each day; wash, rinse, and dry applicator after morning dose and discard after evening dose.214

Dosage Pediatric Patients Bacterial Vaginosis Treatment in Nonpregnant Postmenarchal Females Intravaginal

0.75% gel: One applicatorful (approximately 37.5 g of metronidazole) once daily (at bedtime) or twice daily (in morning and evening) given for 5 consecutive days.214

Adults Rosacea Topical

0.75% cream or lotion: Apply thin film to cleansed, affected area twice daily (morning and evening)180 207 or as directed by clinician.207

1% cream or gel: Apply thin film to cleansed, affected area once daily.1 184

Optimum treatment duration not established;10 17 18 19 21 47 81 has been continued for ?21 weeks in clinical studies.2 9 10 16 17 18 19 20 21 29

Chronic therapy (usually intermittent) may be necessary, particularly for moderate to severe disease.61 99

Clinical improvement usually occurs within 3 weeks.17 21 Once adequate response occurs, adjust frequency and duration of treatment according to disease course.47

Although disease may remit during treatment,17 18 19 relapse occurs commonly following discontinuance.17 18 19 47 61 99

Bacterial Vaginosis Treatment in Nonpregnant Women Intravaginal

0.75% gel: One applicatorful (approximately 37.5 g of metronidazole) once daily (at bedtime) or twice daily (in morning and evening) given for 5 consecutive days.109 111 112 114 115 183 214

Cautions for Metronidazole Contraindications

Known hypersensitivity to metronidazole, other nitroimidazole derivatives, or any ingredient in the formulation.1 180 183 184 207 214

Warnings/Precautions Warnings Seizures and Peripheral Neuropathy

Convulsive seizures and peripheral neuropathy (characterized by numbness or paresthesia of an extremity) reported with oral or IV nitroimidazoles (e.g., metronidazole, tinidazole).183 217 214

If abnormal neurologic signs develop with vaginal gel, promptly discontinue drug.183 214

Use vaginal gel with caution in patients with history of CNS disease.183 214

Interactions

Psychotic reactions reported in alcoholic patients receiving oral metronidazole and disulfiram concurrently;183 214 disulfiram-like reactions to alcohol reported in patients receiving oral metronidazole.106 183 214 Similar reactions could occur with intravaginal metronidazole.183 214

Avoid intravaginal metronidazole in patients who have received disulfiram within the last 2 weeks.183 214 Caution patients to avoid drinking alcohol while being treated with intravaginal metronidazole.183 214 (See Specific Drugs under Interactions.)

General Precautions Administration Precautions

Avoid contact with the eyes.1 180 183 184 207 214

Topical cream, gel, or lotion may cause tearing.1 180 184 207

Vaginal gel may cause ocular burning and irritation.183 214

Iirrigate eyes with copious amounts of cool water if contact occurs.183 214

Local Irritation

If reaction suggesting local irritation occurs, advise patient to use the topical preparation less frequently or discontinue use.1 180 184 207

History of Blood Dyscrasia

Use with caution in patients with evidence or history of blood dyscrasia.1 180 184 207

Transient leukopenia and neutropenia reported with systemic metronidazole;30 adverse hematologic abnormalities not reported to date with topical metronidazole.2 21 47

Vaginal Intercourse and Use of Vaginal Products

Patients treated with vaginal gel should not engage in vaginal intercourse111 112 113 183 214 and should not use other vaginal products (tampons, douches) during entire treatment course.111 112 113 214

Vaginal intercourse or other vaginal products could reduce efficacy of intravaginal metronidazole (e.g., by dislodgment and/or dilution, by increased vaginal pH secondary to deposition of semen).111 112 113 214

Superinfection

Symptoms of known or previously unrecognized vaginal candidiasis may become more prominent during intravaginal metronidazole therapy.183 214 Symptomatic Candida vaginitis reported during or immediately after therapy.183 214

Systemic Adverse Effects

Although topical application to skin results in lower systemic absorption than oral or IV administration, adverse systemic effects (e.g., metallic taste,1 180 207 nausea,1 180 207 paresthesia,184 tingling or numbness of extremities1 180 207 ) have been reported with topical metronidazole.1 180

Although intravaginal administration results in lower systemic absorption than oral or IV administration, consider possibility that adverse effects reported with systemic metronidazole could occur when drug is given intravaginally.115 119 183 214

Specific Populations Pregnancy

Category B.1 180 183 184 207 214

Safety and efficacy of intravaginal metronidazole for treatment of bacterial vaginosis in pregnant women not established.109 119 183 214 Existing data do not support use of intravaginal agents during pregnancy and intravaginal metronidazole not included in current CDC recommendations for treatment of bacterial vaginosis in pregnant women.109

Lactation

Distributed into milk following oral or IV administration;1 30 45 131 180 183 184 207 214 not known whether distributed into milk following topical or intravaginal administration.183 f 214

Discontinue nursing or the drug.1 180 183 184 207 214

Pediatric Use

Safety and efficacy of topical1 180 184 207 or intravaginal183 metronidazole not established in pediatric patients.

One manufacturer states safety and efficacy of vaginal gel established in postmenarchal females based on extrapolation of data from adult women; safety and efficacy of vaginal gel not established in premenarchal females.214

Geriatric Use

Safety and efficacy of topical gel in geriatric patients ?65 years of age appear similar to those in younger adults.1

Insufficient experience with vaginal gel in patients ?65 years of age to determine whether geriatric patients respond differently than younger adults.214

Hepatic Impairment

Use vaginal gel with caution in severe hepatic impairment.183 214

Reduced elimination and increased plasma concentrations may occur in severe hepatic dysfunction.183 214

Common Adverse Effects

Topical application to skin: Local effects such as erythema, irritation, stinging/burning, local allergic reactions, contact dermatitis, drying, pruritus, aggravated rosacea.1 47 180 184 207

Intravaginal administration: Vaginal discharge,183 symptomatic Candida cervicitis/vaginitis,183 fungal infection,214 vulvovaginal irritation,183 dysmenorrhea,214 GI effects (abdominal pain, GI discomfort, nausea, vomiting, diarrhea),183 214 headache,183 214 pruritus.214

Interactions for Metronidazole

Because metronidazole can be absorbed systemically following topical application to skin1 2 9 10 21 47 207 or following intravaginal administration,119 131 132 183 214 the possibility that drug and laboratory test interactions could occur with these routes should be considered.106 183 f

Specific Drugs and Laboratory Tests

Drug

Interaction

Comments

Alcohol

Disulfiram-like reactions reported rarely when alcohol ingested during intravaginal metronidazole treatment;106 183 214 such reactions not reported to date with topical application of metronidazole to skin21 47 61 99

Caution patients to avoid alcohol ingestion during intravaginal metronidazole treatment183 214

Anticoagulants, oral (warfarin)

Prolonged PT reported with systemic metronidazole 1 30 45 92 93 94 95 96 183 214

Consider possibility of potentiated anticoagulant effect if topical or intravaginal metronidazole used with oral anticoagulant therapy180 183 214

Cimetidine

Possible prolonged half-life and decreased clearance of metronidazole with concomitant cimetidine and oral or IV metronidazole182 183 214

Consider possibility of increased metronidazole adverse effects182

Disulfiram

Psychotic reactions reported in alcoholic patients receiving oral metronidazole and disulfiram concurrently92 97 168 169 183 214

Avoid concomitant use;92 97 214 do not initiate intravaginal metronidazole until 2 weeks after discontinuance of disulfiram183 214

Lithium

Increased lithium concentrations resulting in lithium toxicity reported after initiation of short-term oral metronidazole therapy in patients stabilized on relatively high lithium dosages181 183 214

Tests based on ultraviolet (UV) absorbance

Falsely decreased serum concentrations (including undetectable concentrations) of AST, ALT, LDH, triglycerides, or hexokinase glucose may be reported during metronidazole therapy if results are based on decreases in UV absorbance that occur during oxidation-reduction of NADH/NAD30 183 214

UV absorbance peaks of NADH and metronidazole are similar30 183 214

Use caution when interpreting test results based on UV absorbance during metronidazole therapy30 183 214

Metronidazole Pharmacokinetics Absorption Bioavailability

Absorbed systemically following topical application to skin; extent of absorption depends on formulation used (cream, gel, lotion).1 2 9 10 21 47 207

Absorbed systemically following intravaginal administration;119 131 132 183 214 systemic bioavailability of vaginal gel averages 50–56%.119 131 132 183 186

Following repeated topical application to the face of 1% cream (approximately 3.75 mg per dose) in adults with rosacea, serum concentrations were minimal or undetectable.9 Following topical application to the face of 1 g of 1% cream in healthy individuals, serum concentrations were minimal or undetectable and peak serum concentrations were attained within 8–12 hours after the dose.184

Following topical application to the face of 1 g of 1% topical gel in adults with rosacea, peak serum concentrations of metronidazole were attained 6–10 hours after the dose and were <1% of concentrations reported with a single 250-mg oral dose.1

Following topical application to the face of 1 g of 0.75% topical lotion (approximately 7.5 mg of metronidazole) twice daily for 4 days, drug was detectable in plasma of all patients and peak plasma concentrations were approximately 80 times lower than peak concentrations attained with a single 250-mg oral dose.207

Following intravaginal administration of 5 g of 0.75% vaginal gel (approximately 37.5 mg of metronidazole) in healthy women, peak serum concentrations were attained 4–17 hours after the dose and were approximately 2% of that attained after a single 500-mg oral dose.119 132 183 186 214

Distribution Extent

Not fully characterized following topical application to skin10 or intravaginal administration.176 177

Crosses placenta following oral or IV administration;1 30 45 56 131 180 183 184 207 not known whether crosses placenta following topical application to skin1 or intravaginal administration.183

Distributed into milk following oral or IV administration;1 30 45 56 131 180 183 184 207 214 not known whether distributed into milk following topical application to skin1 or intravaginal administration.183

Elimination Metabolism

Not fully characterized following topical application to skin10 or intravaginal administration.176 177

Elimination Route

Any systemically absorbed drug probably metabolized in liver and excreted in urine.10 61

Stability Storage Topical Cream

20–25°C.180 184

Gel

20–25°C (may be exposed to 15–30°C).1

Lotion

20–25°C; do not freeze.207

Intravaginal Gel

MetroGel-Vaginal: 15–30°C; do not freeze.183

Vandazole: 20–25°C; do not freeze.214

ActionsActions

Bactericidal, amebicidal, and trichomonacidal in action.2 30 48 52 56

Un-ionized at physiologic pH49 and readily taken up by anaerobic organisms or cells.48 49 50 56 72 In susceptible organisms or cells, metronidazole reduced by low-redox-potential electron transport proteins (e.g., nitroreductases such as ferredoxin);48 49 50 56 64 65 66 68 69 70 71 72 the reduction product(s) apparently are responsible for cytotoxic and antimicrobial effects of the drug (e.g., disruption of DNA, inhibition of nucleic acid synthesis).48 56 63 64 65 66 67 68 70 71 72

Has direct anti-inflammatory effects2 14 17 21 28 180 and effects on neutrophil motility, lymphocyte transformation, and some aspects of cell-mediated immunity.2 10 32 33 34 35

Mechanism of reducing inflammatory lesions (papules and pustules) and erythema in patients with rosacea not elucidated to date;1 2 6 10 11 17 19 21 28 29 184 207 these effects may result from anti-inflammatory or immunosuppressive actions of the drug.1 2 3 10 17 28 29 207

Suppression of skin bacteria does not appear to play a major role in the mechanism of action of the drug in treatment of inflammatory lesions of rosacea;2 10 11 29 inactive in vitro against Propionibacterium acnes,2 4 5 48 staphylococci, and streptococci,2 48 and has no appreciable effects on the aerobic or anaerobic microflora of the skin of patients with rosacea.2 10 29

Spectrum of activity includes most obligately anaerobic bacteria2 7 29 30 45 48 53 56 64 and many protozoa.2 29 30 48 52 64 Inactive against fungi2 3 48 and viruses48 and most aerobic or facultatively anaerobic bacteria.2 7 30 45 48 73 74

Gram-positive anaerobes: Active against Clostridium,2 30 45 48 53 55 C. difficile,54 55 C. perfringens,48 55 Eubacterium,2 30 45 48 53 54 Peptococcus,2 30 45 48 53 54 55 and Peptostreptococcus.2 7 30 45 48 53 55 124 128 Actinomyces, Lactobacillus,48 Propionibacterium acnes,2 4 5 48 P. avidum,5 and P. granulosum5 generally are resistant.

Gram-negative anaerobes: Active against Bacteroides fragilis,2 3 30 45 48 53 54 55 124 126 130 B. distasonis,30 45 54 55 124 B. ovatus,30 45 55 124 B. thetaiotaomicron,30 45 54 55 124 B. vulgatus,30 45 54 55 124 B. ureolyticus,124 126 Fusobacterium,2 7 30 45 48 53 55 Prevotella bivia,53 124 126 128 129 P. disiens,54 128 P. intermedia,7 124 P. melaninogenica,48 54 124 126 128 129 P. oralis,54 124 126 129 Porphyromonas,124 129 and Veillonella.7 54 55

Other organisms: Active against Campylobacter fetus.48 Most strains of Gardnerella vaginalis (formerly Haemophilus vaginalis) are susceptible only to relatively high concentrations in vitro.119 126 129 135 140 141 142 Concentrations readily achievable locally (750 mcg/mL) following intravaginal application of 0.75% vaginal gel have inhibited approximately 90% of strains tested in vitro.119 177

Natural and acquired resistance has been reported in some T. vaginalis.48 52 75 76 77 78 79 Resistance also reported rarely in B. fragilis and other anaerobic bacteria following long-term therapy.44 48 215

Advice to Patients

Importance of using topical or intravaginal metronidazole only as directed and only for the disorder for which drug was prescribed.1 180 183 184 207 f

Advise patients that topical cream, gel, and lotion are for external use only and to avoid contact with eyes.1 180 184 207 (See Administration under Dosage and Administration.)

Advise patients that vaginal gel is for intravaginal administration only and to avoid contact with eyes.183 214 (See Administration under Dosage and Administration.) If such contact occurs, importance of irrigating eyes with copious amounts of cool water.177 183

Instruct patients receiving vaginal gel regarding appropriate use of vaginal applicator.f

Advise women using vaginal gel not to engage in vaginal intercourse111


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Salex Lotion


Generic Name: Salicylic Acid (sal-ih-SILL-ik AS-id)
Brand Name: Salex
Salex Lotion is used for:

Removing excess skin in certain conditions, including calluses, psoriasis, and warts. It may also be used for other conditions as determined by your doctor.

Salex Lotion is a topical salicylate. It works by causing the skin to swell, soften, and then slough or peel in areas where it is applied.

Do NOT use Salex Lotion if: you are allergic to any ingredient in Salex Lotion

Contact your doctor or health care provider right away if any of these apply to you.

Before using Salex Lotion:

Some medical conditions may interact with Salex Lotion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib) if you have liver or kidney problems, a skin infection, skin irritation, diabetes, or poor blood circulation

Some MEDICINES MAY INTERACT with Salex Lotion. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants, (eg, heparin, warfarin), aspirin, methotrexate, or sulfonylureas (eg, glipizide) because the risk of side effects may be increased by Salex Lotion

This may not be a complete list of all interactions that may occur. Ask your health care provider if Salex Lotion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Salex Lotion:

Use Salex Lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Apply Salex Lotion in the evening unless otherwise directed by your doctor. Soak the affected area in warm water for about 5 minutes. Remove any loose skin with a brush, washcloth, or emery board. Completely dry the affected area. Apply a thin film of medicine to the affected area and gently massage until the medicine is evenly distributed. Wash the medicine off in the morning. If excessive drying or irritation occurs, a mild cream or lotion may be applied. Unless directed otherwise by your doctor, cover the area with a small adhesive bandage or dressing. Unless your hands are being treated, be sure to wash your hands after each use. Talk with your doctor if you are not able to cover the affected area (eg, if it is hard to wrap). If you miss a dose of Salex Lotion, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Salex Lotion.

Important safety information: Salex Lotion is for external use only. Avoid getting Salex Lotion in your eyes, nose, or mouth, or on the genitals. If contact with your eyes occurs, flush with water for 15 minutes. Do not inhale the vapors of Salex Lotion. Do not use Salex Lotion longer or more often than recommended by your doctor or on the package label. Check with your doctor before use if you have a condition that covers a large area of the body. Be sure to apply Salex Lotion only to the affected area and not to normal healthy skin. Do not use Salex Lotion on skin that is irritated, infected, or reddened. Do not use Salex Lotion on open skin wounds, moles, birthmarks, genital warts, warts on the face, or warts growing hair. Do not use any other medicines or drying products on your skin unless your doctor instructs you otherwise. Salex Lotion may interfere with certain lab test results. Make sure your doctor and lab personnel know you are using Salex Lotion. Salex Lotion is extremely flammable. Do not store or use Salex Lotion near a fire or other open flame. Salex Lotion may be harmful if swallowed. If you may have taken Salex Lotion by mouth, contact your local poison control center or emergency room immediately. Salex Lotion contains a salicylate, which has been linked to Reye syndrome. Do not use Salex Lotion on children or teenagers during or after chickenpox, flu, or other viral infections without checking with your doctor or pharmacist. Use of Salex Lotion is not recommended in CHILDREN younger than 2 years of age. Safety and efficacy in this age group have not been confirmed. Caution is advised when using Salex Lotion in CHILDREN younger than 12 years of age because they may be more sensitive to its effects. PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Salex Lotion during pregnancy. It is unknown if Salex Lotion is excreted in breast milk. Do not breast-feed while you are using Salex Lotion. Possible side effects of Salex Lotion:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry, peeling, red, or scaling skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe irritation.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Salex side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; diarrhea; dizziness; loss of appetite; loss of hearing; mental disturbances; nausea; rapid or difficult breathing; ringing in the ears; seizures; sluggishness; vomiting; yellowing of the skin or eyes.

Proper storage of Salex Lotion:

Store Salex Lotion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not freeze. Do not store in the bathroom. Keep Salex Lotion out of the reach of children and away from pets.

General information: If you have any questions about Salex Lotion, please talk with your doctor, pharmacist, or other health care provider. Salex Lotion is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Salex Lotion. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Salex resources Salex Side Effects (in more detail) Salex Use in Pregnancy & Breastfeeding Salex Drug Interactions Salex Support Group 0 Reviews for Salex - Add your own review/rating Compare Salex with other medications Acne Dermatological Disorders
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Calamine Lotion Topical


Generic Name: calamine (Topical route)

KAL-a-mine

Commonly used brand name(s)

In Canada

Calamine Lotion

Available Dosage Forms:

Ointment Lotion Cream

Therapeutic Class: Antipruritic

Uses For Calamine Lotion

Calamine is used to relieve the itching, pain, and discomfort of minor skin irritations, such as those caused by poison ivy, poison oak, and poison sumac. This medicine also dries oozing and weeping caused by poison ivy, poison oak, and poison sumac.

Calamine is available without prescription.

Before Using Calamine Lotion

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Although there is no specific information comparing use of calamine in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of calamine in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of Calamine Lotion

Calamine is for external use only. Do not swallow it and do not use it on the eyes or mucous membranes such as the inside of the mouth, nose, genital (sex organs), or anal areas.

To use calamine lotion:

Shake the lotion well before using. Moisten a pledget of cotton with the lotion. Use the moistened pledget to apply the lotion to the affected skin area(s). Allow the medicine to dry on the skin.

To use calamine ointment:

Apply enough medicine to cover affected skin area(s) and rub in gently. Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For minor skin irritations: For topical dosage forms (lotion, ointment): Adults and children—Apply to the affected area(s) of skin as often as needed. Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Calamine Lotion

If your condition gets worse or if it does not improve within 7 days, or if rash or irritation develops, stop using calamine and check with your doctor.

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Calamine Lotion Topical resources Calamine Lotion Topical Side Effects (in more detail) Calamine Lotion Topical Use in Pregnancy & Breastfeeding Calamine Lotion Topical Support Group 1 Review for Calamine Topical - Add your own review/rating Compare Calamine Lotion Topical with other medications Pruritus
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Topical antihistamines


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Topical antihistamine products are where antihistamines have been incorporated in creams, nasal sprays and other agents that can be applied locally (for example to the skin) to treat allergic reactions.

Antihistamines block the histamine receptors, which when activated cause allergic reactions such as hay fever, itching and rash. Topical antihistamines are used to relieve the symptoms of hay fever, itching and to resolve rashes due to allergy.

See also

Medical conditions associated with topical antihistamines:

Atopic Dermatitis Dermatitis Eczema Lichen Simplex Chronicus Pain Pruritus Drug List: Ivarest Derma-Pax-Lotion Dermarest-Cream Prudoxin-Topical Zonalon-Cream
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Neutrogena Lotion


Generic Name: topical emollients (TOP i kal ee MOL i ents)
Brand Names: Aloe Vesta Cream, AlphaSoft, AmeriPhor, Aqua Glycolic, Aqua Lube, Aquaphor, Aveeno, Baby Lotion, Baby Oil, Bag Balm, Baza-Pro, Beta Care, Blistex Lip Balm, Carmex, CarraKlenz, CeraVe, CeraVe AM, Cetaphil Lotion, Chap Stick, Citraderm, CoolBottoms, Corn Huskers Lotion, Curel Moisture Lotion, Derma Soothe, Dr Scholl's Essentials Cracked Skin Repair, Eucerin, Herpecin-L, K-Y Jelly, Keri Lotion, Lamisilk Heel Balm, Lubri-Soft, Lubriderm, Mederma, Moisturel, Natural Ice, NeutrapHor, NeutrapHorus Rex, Neutrogena Cleansing, Neutrogena Lotion, Nivea, Nutraderm, Pacquin, Phisoderm, Pretty Feet & Hands, Proshield Skincare Kit, Remedy 4-in-1 Cleansing Lotion, Replens, Secura, Sensi-Care, Soft Sense, St. Ives, Theraplex Lotion, Vaseline Intensive Care

What are Neutrogena Lotion (topical emollients)?

Emollients are substances that moisten and soften your skin.

Topical (for the skin) emollients are used to treat or prevent dry skin. Topical emollients are sometimes contained in products that also treat acne, chapped lips, diaper rash, cold sores, or other minor skin irritation.

There are many brands and forms of topical emollients available and not all are listed on this leaflet.

Topical emollients may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Neutrogena Lotion (topical emollients)? You should not use a topical emollient if you are allergic to it. Topical emollients will not treat or prevent a skin infection.

Ask a doctor or pharmacist before using this medication if you have deep wounds or open sores, swelling, warmth, redness, oozing, bleeding, large areas of skin irritation, or any type of allergy.

What should I discuss with my healthcare provider before using Neutrogena Lotion (topical emollients)? You should not use a topical emollient if you are allergic to it. Topical emollients will not treat or prevent a skin infection.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:

deep wounds or open sores;

swelling, warmth, redness, oozing, or bleeding;

large areas of skin irritation;

any type of allergy; or

if you are pregnant or breast-feeding. How should I use Neutrogena Lotion (topical emollients)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Clean the skin where you will apply the topical emollient. It may help to apply this product when your skin is wet or damp. Follow directions on the product label.

Shake the product container if recommended on the label.

Apply a small amount of topical emollient to the affected area and rub in gently.

If you are using a stick, pad, or soap form of topical emollient, follow directions for use on the product label.

Do not use this product over large area of skin. Do not apply a topical emollient to a deep puncture wound or severe burn without medical advice.

If your skin appears white or gray and feels soggy, you may be applying too much topical emollient or using it too often.

Some forms of topical emollient may be flammable and should not be used near high heat or open flame, or applied while you are smoking.

Store as directed away from moisture, heat, and light. Keep the bottle, tube, or other container tightly closed when not in use.

What happens if I miss a dose?

Since this product is used as needed, it does not have a daily dosing schedule. Seek medical advice if your condition does not improve after using a topical emollient.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Neutrogena Lotion (topical emollients)? Avoid getting topical emollients in your eyes, nose, or mouth. If this does happen, rinse with water. Avoid exposure to sunlight or tanning beds. Some topical emollients can make your skin more sensitive to sunlight or UV rays. Neutrogena Lotion (topical emollients) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using the topical emollient and call your doctor if you have severe burning, stinging, redness, or irritation where the product was applied.

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Neutrogena Lotion (topical emollients)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied products. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Neutrogena Lotion resources Neutrogena Lotion Use in Pregnancy & BreastfeedingNeutrogena Lotion Support Group0 Reviews for Neutrogena - Add your own review/rating Biafine Emulsion MedFacts Consumer Leaflet (Wolters Kluwer) Campath Monograph (AHFS DI) Campral Monograph (AHFS DI) Camptosar Monograph (AHFS DI) Diabinese Monograph (AHFS DI) Kinerase Cream MedFacts Consumer Leaflet (Wolters Kluwer) Neosalus Foam MedFacts Consumer Leaflet (Wolters Kluwer) Promiseb Cream MedFacts Consumer Leaflet (Wolters Kluwer) Compare Neutrogena Lotion with other medications Dry Skin Where can I get more information? Your pharmacist can provide more information about topical emollients.
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Corn Huskers Lotion


Generic Name: topical emollients (TOP i kal ee MOL i ents)
Brand Names: Aloe Vesta Cream, AlphaSoft, AmeriPhor, Aqua Glycolic, Aqua Lube, Aquaphor, Aveeno, Baby Lotion, Baby Oil, Bag Balm, Baza-Pro, Beta Care, Blistex Lip Balm, Carmex, CarraKlenz, CeraVe, CeraVe AM, Cetaphil Lotion, Chap Stick, Citraderm, CoolBottoms, Corn Huskers Lotion, Curel Moisture Lotion, Derma Soothe, Dr Scholl's Essentials Cracked Skin Repair, Eucerin, Herpecin-L, K-Y Jelly, Keri Lotion, Lamisilk Heel Balm, Lubri-Soft, Lubriderm, Mederma, Moisturel, Natural Ice, NeutrapHor, NeutrapHorus Rex, Neutrogena Cleansing, Neutrogena Lotion, Nivea, Nutraderm, Pacquin, Phisoderm, Pretty Feet & Hands, Proshield Skincare Kit, Remedy 4-in-1 Cleansing Lotion, Replens, Secura, Sensi-Care, Soft Sense, St. Ives, Theraplex Lotion, Vaseline Intensive Care

What are Corn Huskers Lotion (topical emollients)?

Emollients are substances that moisten and soften your skin.

Topical (for the skin) emollients are used to treat or prevent dry skin. Topical emollients are sometimes contained in products that also treat acne, chapped lips, diaper rash, cold sores, or other minor skin irritation.

There are many brands and forms of topical emollients available and not all are listed on this leaflet.

Topical emollients may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Corn Huskers Lotion (topical emollients)? You should not use a topical emollient if you are allergic to it. Topical emollients will not treat or prevent a skin infection.

Ask a doctor or pharmacist before using this medication if you have deep wounds or open sores, swelling, warmth, redness, oozing, bleeding, large areas of skin irritation, or any type of allergy.

What should I discuss with my healthcare provider before using Corn Huskers Lotion (topical emollients)? You should not use a topical emollient if you are allergic to it. Topical emollients will not treat or prevent a skin infection.

Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:

deep wounds or open sores;

swelling, warmth, redness, oozing, or bleeding;

large areas of skin irritation;

any type of allergy; or

if you are pregnant or breast-feeding. How should I use Corn Huskers Lotion (topical emollients)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Clean the skin where you will apply the topical emollient. It may help to apply this product when your skin is wet or damp. Follow directions on the product label.

Shake the product container if recommended on the label.

Apply a small amount of topical emollient to the affected area and rub in gently.

If you are using a stick, pad, or soap form of topical emollient, follow directions for use on the product label.

Do not use this product over large area of skin. Do not apply a topical emollient to a deep puncture wound or severe burn without medical advice.

If your skin appears white or gray and feels soggy, you may be applying too much topical emollient or using it too often.

Some forms of topical emollient may be flammable and should not be used near high heat or open flame, or applied while you are smoking.

Store as directed away from moisture, heat, and light. Keep the bottle, tube, or other container tightly closed when not in use.

What happens if I miss a dose?

Since this product is used as needed, it does not have a daily dosing schedule. Seek medical advice if your condition does not improve after using a topical emollient.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Corn Huskers Lotion (topical emollients)? Avoid getting topical emollients in your eyes, nose, or mouth. If this does happen, rinse with water. Avoid exposure to sunlight or tanning beds. Some topical emollients can make your skin more sensitive to sunlight or UV rays. Corn Huskers Lotion (topical emollients) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using the topical emollient and call your doctor if you have severe burning, stinging, redness, or irritation where the product was applied.

Less serious side effects are more likely, and you may have none at all.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Corn Huskers Lotion (topical emollients)?

It is not likely that other drugs you take orally or inject will have an effect on topically applied products. But many drugs can interact with each other. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Corn Huskers Lotion resources Corn Huskers Lotion Use in Pregnancy & Breastfeeding Corn Huskers Lotion Support Group 0 Reviews for Corn Huskers - Add your own review/rating Biafine Emulsion MedFacts Consumer Leaflet (Wolters Kluwer) Campath Monograph (AHFS DI) Campral Monograph (AHFS DI) Camptosar Monograph (AHFS DI) Diabinese Monograph (AHFS DI) Kinerase Cream MedFacts Consumer Leaflet (Wolters Kluwer) Neosalus Foam MedFacts Consumer Leaflet (Wolters Kluwer) Promiseb Cream MedFacts Consumer Leaflet (Wolters Kluwer) Compare Corn Huskers Lotion with other medications Dry Skin Where can I get more information? Your pharmacist can provide more information about topical emollients.
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Full Marks Lotion


1. Name Of The Medicinal Product

Full Marks Lotion.

2. Qualitative And Quantitative Composition

Full Marks Lotion contains:

Phenothrin 0.2% w/v

3. Pharmaceutical Form

Lotion

4. Clinical Particulars 4.1 Therapeutic Indications

For the treatment of head lice and pubic lice infestation.

4.2 Posology And Method Of Administration

For topical external use only.

The source of infestation should be sought and treated.

For adults, the elderly, and children aged over 6 months

For head lice:

1. Sprinkle the lotion on the hair and rub gently onto the head until the entire scalp is moistened. Pay special attention to the back of the neck and the area behind the ears. Take care to avoid the eyes.

2. Allow to dry naturally. Use no heat.

3. The hair may be washed with a standard shampoo 2 hours after application.

4. Whilst still wet, comb the hair with an ordinary comb. A fine-toothed louse comb can then be used to remove the dead lice and eggs.

For pubic lice:

Application and dosage etc. are as for the head. Apply the lotion to the pubic hair and the hair between the legs and around the anus. Allow to dry naturally, using no heat.

4.3 Contraindications

A history of sensitivity to pyrethroid insecticides.

4.4 Special Warnings And Precautions For Use

Do not use in children aged under 6 months except under medical supervision.

Do not use on broken or secondarily infected skin.

Full Marks Lotion contains isopropyl alcohol which may cause wheezing in asthmatic patients or cause inflammation of the skin in patients with severe eczema. If such effects are apparent, patients should use a shampoo formulation.

Contains flammable alcohol. Apply and dry with care. Avoid naked flames or lighted objects. Do not use artificial heat (e.g. electric hairdryers). Dry in a well ventilated room. Do not cover the head before the lotion has dried completely. The hair should be dry before retiring to bed.

When Full Marks Lotion is used by a school nurse or other health officer in the mass treatment of large numbers of children, it is advisable that protective plastic or rubber gloves be worn.

Prolonged repeated use with this product should be avoided. It should not be used more than once a week, and for not more than three consecutive weeks.

This treatment may affect permed, pre-rinsed, coloured or bleached hair. If your hair has been permed, pre-rinsed, coloured or bleached, Full Marks Lotion should be applied to a small section of hair for 30 minute, and checked for any reaction, before applying the treatment to a full head.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None stated.

4.6 Pregnancy And Lactation

There are no known effects in pregnancy and lactation. However, as with all drugs, Full Marks Lotion should be used with caution in pregnant or lactating women.

4.7 Effects On Ability To Drive And Use Machines

None stated.

4.8 Undesirable Effects

Some patients may experience stinging or inflammation of the skin due to the alcohol content.

4.9 Overdose

In the event of deliberate or accidental ingestion, as for ethyl alcohol, empty the stomach by gastric lavage and treat symptomatically.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Phenothrin is a synthetic pyrethroid insecticide, highly effective against human lice but with an exceptionally low mammalian toxicity.

5.2 Pharmacokinetic Properties

Full Marks Lotion is applied topically to the affected area. A pharmacokinetic study has shown absorption of the active constituent is negligible.

5.3 Preclinical Safety Data

None stated.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Herbal Green Bouquet P15312

Isopropanol

Purified Water

6.2 Incompatibilities

None stated.

6.3 Shelf Life

Three years.

6.4 Special Precautions For Storage

Store bottle in carton at or below 30oC protected from light.

6.5 Nature And Contents Of Container

Cartoned, clear or amber glass bottles with polyethylene caps and polypropylene sprinkler inserts containing either 50, 55, 110, 160 or 200 ml of product.

Not all pack sizes may be marketed

6.6 Special Precautions For Disposal And Other Handling

None stated.

7. Marketing Authorisation Holder

Seton Products Ltd

Tubiton House

Oldham

OL1 3HS

8. Marketing Authorisation Number(S)

PL 11314/0047.

9. Date Of First Authorisation/Renewal Of The Authorisation

27/11/1995.

10. Date Of Revision Of The Text

September 2006


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MetroCream


metronidazole
Dosage Form: topical cream
MetroCream®
(metronidazole topical cream)
Rx Only
FOR TOPICAL USE ONLY
(NOT FOR OPHTHALMIC USE) DESCRIPTION:

MetroCream® Topical Cream contains metronidazole, USP, at a concentration of 7.5 mg per gram (0.75%) in an emollient cream consisting of benzyl alcohol, emulsifying wax, glycerin, isopropyl palmitate, purified water, sorbitol solution, lactic acid and/or sodium hydroxide to adjust pH. Metronidazole is a member of the imidazole class of antibacterial agents and is classified therapeutically as an antiprotozoal and anti-bacterial agent. Chemically, metronidazole is 2-methyl-5-nitro-1 H-imidazole-1-ethanol. The molecular formula is C6H9N3O3 and molecular weight is 171.16. Metronidazole is represented by the following structural formula:

CLINICAL PHARMACOLOGY:

The mechanisms by which metronidazole acts in the treatment of rosacea are unknown, but appear to include an anti-inflammatory effect.

INDICATIONS AND USAGE:

MetroCream® (metronidazole topical cream) Topical Cream is indicated for topical application in the treatment of inflammatory papules and pustules of rosacea.

CONTRAINDICATIONS:

MetroCream® (metronidazole topical cream) Topical Cream is contraindicated in individuals with a history of hypersensitivity to metronidazole, or other ingredients of the formulation.

PRECAUTIONS:

General: Topical metronidazole has been reported to cause tearing of the eyes. Therefore, contact with the eyes should be avoided. If a reaction suggesting local irritation occurs, patients should be directed to use the medication less frequently or discontinue use. Metronidazole is a nitroimidazole and should be used with care in patients with evidence of, or history of blood dyscrasia.

Information for patients: This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.

Drug interactions: Oral metronidazole has been reported to potentiate the anticoagulant effect of warfarin and coumarin anticoagulants, resulting in a prolongation of prothrombin time. The effect of topical metronidazole on prothrombin time is not known.

Carcinogenesis, mutagenesis, impairment of fertility: Metronidazole has shown evidence of carcinogenic activity in a number of studies involving chronic, oral administration in mice and rats but not in studies involving hamsters.

Metronidazole has shown evidence of mutagenic activity in several in vitro bacterial assay systems. In addition, a dose-response increase in the frequency of micronuclei was observed in mice after intraperitoneal injections and an increase in chromosome aberrations have been reported in patients with Crohn’s disease who were treated with 200-1200 mg/day of metronidazole for 1 to 24 months. However, no excess chromosomal aberrations in circulating human lymphocytes have been observed in patients treated for 8 months.

Pregnancy: Teratogenic effects: Pregnancy category B: There are no adequate and well-controlled studies with the use of MetroCream® (metronidazole topical cream) Topical Cream in pregnant women. Metronidazole crosses the placental barrier and enters the fetal circulation rapidly. No fetotoxicity was observed after oral metronidazole in rats or mice. However, because animal reproduction studies are not always predictive of human response and since oral metronidazole has been shown to be a carcinogen in some rodents, this drug should be used during pregnancy only if clearly needed.

Nursing mothers: After oral administration, metronidazole is secreted in breast milk in concentrations similar to those found in the plasma. Even though blood levels are significantly lower with topically applied metronidazole than those achieved after oral administration of metronidazole, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric use: Safety and effectiveness in pediatric patients have not been established.

ADVERSE REACTIONS:

In controlled clinical trials, the total incidence of adverse reactions associated with the use of MetroCream® Topical Cream was approximately 10%. Skin discomfort (burning and stinging) was the most frequently reported event followed by erythema, skin irritation, pruritus and worsening of rosacea. All individual events occurred in less than 3% of patients. The following additional adverse experiences have been reported with the topical use of metronidazole: dryness, transient redness, metallic taste, tingling or numbness of extremities and nausea.

DOSAGE AND ADMINISTRATION:

Apply and rub in a thin layer of MetroCream® (metronidazole topical cream) Topical Cream twice daily, morning and evening, to entire affected areas after washing.

Areas to be treated should be washed with a mild cleanser before application. Patients may use cosmetics after application of MetroCream® Topical Cream.

HOW SUPPLIED:

MetroCream® (metronidazole topical cream) Topical Cream, 0.75% is supplied in a 45 g aluminum tube - NDC 0299-3836-45.

Storage conditions: STORE AT CONTROLLED ROOM TEMPERATURE: 68° to 77°F (20° to 25°C).

Marketed by:
GALDERMA LABORATORIES, L.P.
Fort Worth, Texas 76177 USA
Manufactured by:
Galderma Production Canada, Inc.
Montreal, QC
H9X 3N7 Canada
GALDERMA is a registered trademark.
Made in Canada.
P50309-0
Revised: December 2002

PACKAGE LABEL:

MetroCream®
(metronidazole topical cream)

TOPICAL CREAM

0.75%

NET WT. 45 g

NDC 0299-3836-45

Rx only

GALDERMA

FOR TOPICAL USE ONLY. NOT FOR OPHTHALMIC USE.
STORE AT CONTROLLED ROOM TEMPERATURE, 68° TO 77°F (20°-25°C).
Usual dosage: Apply a thin layer to entire affected areas after washing. Use morning and evening or as directed by physician. Avoid application close to the eyes.
Each gram contains: Active: metronidazole 0.75% (7.5 mg). Inactive: benzyl alcohol, emulsifying wax, glycerin, isopropyl palmitate, purified water, sorbitol solution, lactic acid and/or sodium hydroxide to adjust pH.

Marketed by:
GALDERMA LABORATORIES, L.P.
Fort Worth, TX 76177 USA
GALDERMA is a registered trademark.
Manufactured by:
Galderma Production Canada, Inc.
Montreal, QC
H9X 3N7 Canada
Made in Canada.
P50296-1

LOT:
EXP.:


MetroCream  
metronidazole  cream Product Information Product Type HUMAN PRESCRIPTION DRUG NDC Product Code (Source) 0299-3836 Route of Administration TOPICAL DEA Schedule      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Metronidazole (Metronidazole) Metronidazole 7.5 mg  in 1 g Inactive Ingredients Ingredient Name Strength Benzyl Alcohol   Glycerin   Isopropyl Palmitate   Water   Sorbitol   Lactic Acid   Sodium Hydroxide   Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains          Packaging # NDC Package Description Multilevel Packaging 1 0299-3836-45 1 TUBE In 1 CARTON contains a TUBE 1 45 g In 1 TUBE This package is contained within the CARTON (0299-3836-45)
Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020531 09/20/1995
Labeler - Galderma Laboratories, L.P. (047350186) Establishment Name Address ID/FEI Operations DPT Laboratories, Ltd. 832224526 MANUFACTURE Establishment Name Address ID/FEI Operations Galderma Production Canada Inc 251676961 MANUFACTURE Revised: 03/2011Galderma Laboratories, L.P.
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