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Caverject


Pronunciation: al-PROS-ta-dil
Generic Name: Alprostadil
Brand Name: Examples include Caverject and Edex
Caverject is used for:

Treating erectile problems in men. It may also be used to help diagnose erectile dysfunction.

Caverject is a prostaglandin (PGE-1). It works by relaxing certain muscles in the penis and widening blood vessels, which increases blood flow to the penis and helps to cause an erection. When the effect of the alprostadil wears off, blood flow returns to normal and the erection disappears.

Do NOT use Caverject if: you are allergic to any ingredient in Caverject you have blood problems (eg, sickle cell anemia or sickle cell trait, leukemia), bone marrow problems (eg, multiple myeloma), or other conditions that may increase your risk for a prolonged, painful erection (priapism) you have a penile implant, deformed penis, or certain other penile problems (eg, Peyronie disease, fibrosis of the penis) you have any other physical reason that you should not have sexual intercourse

Contact your doctor or health care provider right away if any of these apply to you.

Before using Caverject:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have inflammation or infection of the penis, kidney problems, urinary problems (eg, inflammation or narrowing of the urethra), or a history of prolonged or painful erections if you use other medicine for erectile problems if you have a blood-borne disease (eg, HIV, hepatitis)

Some MEDICINES MAY INTERACT with Caverject. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) or heparin because the risk of bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Caverject may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Caverject:

Use Caverject as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Caverject. Talk to your pharmacist if you have questions about this information. Caverject is injected into the penis to produce an erection. A health care provider will teach you how to prepare and use Caverject. Be sure you understand how to use Caverject. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. Do not use Caverject if it contains particles, is cloudy or discolored, or if the cartridge is cracked or damaged. Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. Caverject usually starts to work within 5 to 20 minutes after you inject it and lasts about 30 to 60 minutes. Do not use more than one dose of Caverject in a 24-hour period or more than 3 doses per week without first checking with your doctor. If you forget to use Caverject and you still intend to engage in sexual activity, use it as soon as you remember or as directed by your doctor.

Ask your health care provider any questions you may have about how to use Caverject.

Important safety information: Caverject may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Caverject with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do NOT use more than the recommended dose or change your dose without checking with your doctor. Seek medical attention if you experience a painful erection or have an erection that lasts for more than 4 hours (priapism). If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Caverject does not protect against the spread of sexually transmitted diseases (STDs) (eg, HIV) or blood-borne diseases (eg, hepatitis B). Use barrier methods of birth control (eg, condoms) if you have an STD or blood-borne disease. If your partner experiences vaginal dryness or painful vaginal sensations, talk with your doctor. It might be necessary to use a water-based lubricant during sexual intercourse. You will need to have regular check-ups with your doctor while you are using Caverject. Be sure to keep all doctor and lab appointments. Use Caverject with caution in the ELDERLY; they may be more sensitive to its effects. PREGNANCY AND BREAST-FEEDING: It is not known if Caverject can cause harm to the fetus. It is not known if Caverject if found in breast milk. Caverject is not approved for use in women. Possible side effects of Caverject:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild bleeding at the injection site; mild genital pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal ejaculation; bleeding from the tip of the penis; bloody urine or change in the amount of urine; chest pain; curving of the erect penis; dizziness; fainting; fast or irregular heartbeat; new or worsening genital pain; painful or prolonged erection; redness, lumps, swelling, tenderness, inflammation, numbness, strange sensation, or discoloration of the penis; severe or persistent bleeding or bruising at the injection site; severe or persistent pain, swelling, or redness at the injection site; swelling of the leg veins; white patches or discharge from the penis.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Caverject side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; lasting pain in the penis; lightheadedness; painful or prolonged erection (eg, erection lasting more than 4 hours).

Proper storage of Caverject:

Caverject: Before mixing, store Caverject at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. After mixing, you may store Caverject below 77 degrees (25 degrees C) for up to 24 hours. Do not refrigerate or freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Caverject out of the reach of children and away from pets.

Edex: Store Caverject at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not refrigerate or freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Caverject out of the reach of children and away from pets.

General information: If you have any questions about Caverject, please talk with your doctor, pharmacist, or other health care provider. Caverject is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Caverject. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Caverject resources Caverject Side Effects (in more detail) Caverject Use in Pregnancy & Breastfeeding Caverject Drug Interactions Caverject Support Group 2 Reviews for Caverject - Add your own review/rating Compare Caverject with other medications Erectile Dysfunction
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Caverject Impulse


Pronunciation: al-PROS-ta-dil
Generic Name: Alprostadil
Brand Name: Examples include Caverject and Caverject Impulse
Caverject Impulse is used for:

Treating erectile problems in men. It may also be used to help diagnose erectile dysfunction.

Caverject Impulse is a prostaglandin (PGE-1). It works by relaxing certain muscles in the penis and widening blood vessels, which increases blood flow to the penis and helps to cause an erection. When the effect of the alprostadil wears off, blood flow returns to normal and the erection disappears.

Do NOT use Caverject Impulse if: you are allergic to any ingredient in Caverject Impulse you have blood problems (eg, sickle cell anemia or sickle cell trait, leukemia), bone marrow problems (eg, multiple myeloma), or other conditions that may increase your risk for a prolonged, painful erection (priapism) you have a penile implant, deformed penis, or certain other penile problems (eg, Peyronie disease, fibrosis of the penis) you have any other physical reason that you should not have sexual intercourse

Contact your doctor or health care provider right away if any of these apply to you.

Before using Caverject Impulse:

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have inflammation or infection of the penis, kidney problems, urinary problems (eg, inflammation or narrowing of the urethra), or a history of prolonged or painful erections if you use other medicine for erectile problems if you have a blood-borne disease (eg, HIV, hepatitis)

Some MEDICINES MAY INTERACT with Caverject Impulse. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) or heparin because the risk of bleeding may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Caverject Impulse may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Caverject Impulse:

Use Caverject Impulse as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Caverject Impulse. Talk to your pharmacist if you have questions about this information. Caverject Impulse is injected into the penis to produce an erection. A health care provider will teach you how to prepare and use Caverject Impulse. Be sure you understand how to use Caverject Impulse. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions. Do not use Caverject Impulse if it contains particles, is cloudy or discolored, or if the cartridge is cracked or damaged. Use Caverject Impulse within 24 hours after mixing. If the needle breaks during the injection, grasp and remove the broken end if possible and contact your doctor. Contact your doctor right away if the needle breaks and you cannot remove it. Use each vial or cartridge one time only. Do not reuse any medicine left in the container. Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal. Caverject Impulse usually starts to work within 5 to 20 minutes after you inject it and lasts about 30 to 60 minutes. Do not use more than one dose of Caverject Impulse in a 24-hour period or more than 3 doses per week without first checking with your doctor. If you forget to use Caverject Impulse and you still intend to engage in sexual activity, use it as soon as you remember or as directed by your doctor.

Ask your health care provider any questions you may have about how to use Caverject Impulse.

Important safety information: Caverject Impulse may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Caverject Impulse with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do NOT use more than the recommended dose or change your dose without checking with your doctor. Seek medical attention if you experience a painful erection or have an erection that lasts for more than 4 hours (priapism). If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Caverject Impulse does not protect against the spread of sexually transmitted diseases (STDs) (eg, HIV) or blood-borne diseases (eg, hepatitis B). Use barrier methods of birth control (eg, condoms) if you have an STD or blood-borne disease. If your partner experiences vaginal dryness or painful vaginal sensations, talk with your doctor. It might be necessary to use a water-based lubricant during sexual intercourse. You will need to have regular check-ups with your doctor while you are using Caverject Impulse. Be sure to keep all doctor and lab appointments. Use Caverject Impulse with caution in the ELDERLY; they may be more sensitive to its effects. PREGNANCY AND BREAST-FEEDING: It is not known if Caverject Impulse can cause harm to the fetus. It is not known if Caverject Impulse if found in breast milk. Caverject Impulse is not approved for use in women. Possible side effects of Caverject Impulse:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild bleeding at the injection site; mild to moderate genital pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal ejaculation; bleeding from the tip of the penis; bloody urine or change in the amount of urine; chest pain; curving of the erect penis; dizziness; fainting; fast or irregular heartbeat; new or worsening genital pain; painful or prolonged erection; redness, lumps, swelling, tenderness, inflammation, numbness, strange sensation, or discoloration of the penis; severe or persistent bleeding or bruising at the injection site; severe or persistent pain, swelling, or redness at the injection site; swelling of the leg veins; white patches or discharge from the penis.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Caverject Impulse side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; lasting pain in the penis; lightheadedness; painful or prolonged erection (eg, erection lasting more than 4 hours).

Proper storage of Caverject Impulse:

Before mixing, store Caverject Impulse at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. After mixing, you may store Caverject Impulse below 77 degrees (25 degrees C) for up to 24 hours. Do not refrigerate or freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Caverject Impulse out of the reach of children and away from pets.

General information: If you have any questions about Caverject Impulse, please talk with your doctor, pharmacist, or other health care provider. Caverject Impulse is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Caverject Impulse. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Caverject Impulse resources Caverject Impulse Side Effects (in more detail) Caverject Impulse Use in Pregnancy & Breastfeeding Caverject Impulse Drug Interactions Caverject Impulse Support Group 3 Reviews for Caverject Impulse - Add your own review/rating Caverject Impulse injectable and transurethral Concise Consumer Information (Cerner Multum) alprostadil Intraurethral, Intravenous, Intracavernosal Advanced Consumer (Micromedex) - Includes Dosage Information Alprostadil Prescribing Information (FDA) Alprostadil Monograph (AHFS DI) Caverject Prescribing Information (FDA) Muse Prescribing Information (FDA) Prostin VR Pediatric Prescribing Information (FDA) Compare Caverject Impulse with other medications Erectile Dysfunction
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Caverject injectable and transurethral


Generic Name: alprostadil (injectable and transurethral) (al PROS ta dil)
Brand Names: Caverject, Caverject Impulse, Edex, Muse

What is alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis. This increases blood flow into the penis, causing an erection.

Alprostadil may also be used for purposes not listed in this medication guide.

What is the most important information I should know about alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

You should not use this medication if you are allergic to alprostadil, or if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's disease, a penile implant, or if you have been told you should not have sexual intercourse for health reasons.

Before using alprostadil, tell your doctor if you have heart disease, high blood pressure, a bleeding disorder, a history of blood clots, or a disease that could be passed in blood (such as hepatitis or HIV).

The injectable form of alprostadil is injected into the side of the penis. The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Use this medication exactly as it was prescribed for you. Using too much alprostadil can be very dangerous. The medicine comes with patient instructions for safe and effective use. Follow these directions carefully.

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Call your doctor, nurse, or pharmacist if you have any questions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes.

Seek emergency medical attention if you have a painful or prolonged erection lasting 4 hours or longer. What should I discuss with my healthcare provider before using alprostadil? You should not use this medication if you are allergic to alprostadil, or if you have:

sickle cell anemia or the sickle cell anemia trait;

leukemia;

a tumor of the bone marrow (multiple myeloma);

a curved or deformed penis;

penile fibrosis or Peyronie's disease;

if you have a penile implant; or

if you have been told you should not have sexual intercourse for health reasons.

To make sure you can safely use alprostadil, tell your doctor if you have any of these other conditions:

a history of blood clots;

heart disease, high blood pressure (hypertension);

a bleeding or blood-clotting disorder; or

a disease that could be passed in blood (such as hepatitis or HIV).

Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant or could become pregnant.

Caverject, Caverject Impulse, Edex, or Muse should not be used by women or by anyone under 18 years old. How should I use alprostadil?

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself. Wait at least 1 day after your first dose before using the medicine again.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Using too much alprostadil can be very dangerous.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different.

The injectable form of alprostadil is injected into the side of the penis.

The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections per week. Allow at least 24 hours to pass between injections.

Alprostadil comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Alprostadil injectable is a powder medicine that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medicine and the sterile liquid. The dose is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Prepare your alprostadil dose only when you are ready to use the medicine. Do not shake the mixed medicine. After mixing, the medication should be clear. Do not use the medication if it looks cloudy or has particles in it. Call your doctor for a new prescription. Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

The Caverject Impulse device uses a very thin needle, which could break easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you cannot remove the broken end, call your doctor right away.

An alprostadil injection can cause bleeding where the needle is placed. This can make it easier for your sexual partner to be exposed to your blood. Before using this medication, tell your doctor if you have a virus such as hepatitis or HIV, which can be passed to another person who comes into contact with your blood.

To be sure this medication is not causing harmful effects, your penis may need to be examined every 3 months. Visit your doctor regularly.

Storing this medicine:

Keep each urethral pellet in its original foil pouch until you are ready to use it. Store the foil pouches in the refrigerator. You may store the pouches at room temperature for up to 14 days. Store alprostadil injectable at room temperature. The 40 microgram strength of unmixed alprostadil can be stored at room temperature for up to 3 months, or until the expiration date on the label, whichever happens first. Do not expose alprostadil products to freezing or very hot temperatures. Do not store your medication in a closed automobile, or pack it into luggage that will be placed into a cargo area during travel. What happens if I miss a dose?

Since alprostadil is used as needed, you will not be on a dosing schedule.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I avoid while using alprostadil? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Taking this medication will not prevent you from passing a disease such as hepatitis or HIV to your sexual partner. Avoid having unprotected sex. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Alprostadil side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using alprostadil and call your doctor at once if you have a serious side effect such as:

feeling light-headed, fainting;

trouble urinating, blood in your urine;

bleeding, bruising, or swelling where you injected the medication;

a painful erection that lasts 4 hours or longer;

severe pain or irritation of your penis or urethra; or

redness, lumps, tenderness, unusual shape or curving of the erect penis.

Less serious side effects may include:

unusual discharge from your penis; or

mild pain in your penis, urethra, or testicles;

headache, dizziness;

back pain;

a rash on the skin of your penis;

itching, warmth, or numbness of your penis;

cough, stuffy nose, cold symptoms, flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Your sexual partner may also have side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.

What other drugs will affect alprostadil?

Tell your doctor about all other medicines you use, especially:

blood pressure medication; or

a blood thinner such as heparin or warfarin (Coumadin, Jantoven).

This list is not complete and other drugs may interact with alprostadil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Caverject resources Caverject Side Effects (in more detail) Caverject Use in Pregnancy & Breastfeeding Caverject Drug Interactions Caverject Support Group 2 Reviews for Caverject - Add your own review/rating Compare Caverject with other medications Erectile Dysfunction Where can I get more information? Your pharmacist can provide more information about alprostadil.

See also: Caverject side effects (in more detail)


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Muse injectable and transurethral


Generic Name: alprostadil (injectable and transurethral) (al PROS ta dil)
Brand Names: Caverject, Caverject Impulse, Edex, Muse

What is alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis. This increases blood flow into the penis, causing an erection.

Alprostadil may also be used for purposes not listed in this medication guide.

What is the most important information I should know about alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

You should not use this medication if you are allergic to alprostadil, or if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's disease, a penile implant, or if you have been told you should not have sexual intercourse for health reasons.

Before using alprostadil, tell your doctor if you have heart disease, high blood pressure, a bleeding disorder, a history of blood clots, or a disease that could be passed in blood (such as hepatitis or HIV).

The injectable form of alprostadil is injected into the side of the penis. The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Use this medication exactly as it was prescribed for you. Using too much alprostadil can be very dangerous. The medicine comes with patient instructions for safe and effective use. Follow these directions carefully.

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Call your doctor, nurse, or pharmacist if you have any questions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes.

Seek emergency medical attention if you have a painful or prolonged erection lasting 4 hours or longer. What should I discuss with my healthcare provider before using alprostadil? You should not use this medication if you are allergic to alprostadil, or if you have:

sickle cell anemia or the sickle cell anemia trait;

leukemia;

a tumor of the bone marrow (multiple myeloma);

a curved or deformed penis;

penile fibrosis or Peyronie's disease;

if you have a penile implant; or

if you have been told you should not have sexual intercourse for health reasons.

To make sure you can safely use alprostadil, tell your doctor if you have any of these other conditions:

a history of blood clots;

heart disease, high blood pressure (hypertension);

a bleeding or blood-clotting disorder; or

a disease that could be passed in blood (such as hepatitis or HIV).

Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant or could become pregnant.

Caverject, Caverject Impulse, Edex, or Muse should not be used by women or by anyone under 18 years old. How should I use alprostadil?

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself. Wait at least 1 day after your first dose before using the medicine again.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Using too much alprostadil can be very dangerous.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different.

The injectable form of alprostadil is injected into the side of the penis.

The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections per week. Allow at least 24 hours to pass between injections.

Alprostadil comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Alprostadil injectable is a powder medicine that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medicine and the sterile liquid. The dose is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Prepare your alprostadil dose only when you are ready to use the medicine. Do not shake the mixed medicine. After mixing, the medication should be clear. Do not use the medication if it looks cloudy or has particles in it. Call your doctor for a new prescription. Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

The Caverject Impulse device uses a very thin needle, which could break easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you cannot remove the broken end, call your doctor right away.

An alprostadil injection can cause bleeding where the needle is placed. This can make it easier for your sexual partner to be exposed to your blood. Before using this medication, tell your doctor if you have a virus such as hepatitis or HIV, which can be passed to another person who comes into contact with your blood.

To be sure this medication is not causing harmful effects, your penis may need to be examined every 3 months. Visit your doctor regularly.

Storing this medicine:

Keep each urethral pellet in its original foil pouch until you are ready to use it. Store the foil pouches in the refrigerator. You may store the pouches at room temperature for up to 14 days. Store alprostadil injectable at room temperature. The 40 microgram strength of unmixed alprostadil can be stored at room temperature for up to 3 months, or until the expiration date on the label, whichever happens first. Do not expose alprostadil products to freezing or very hot temperatures. Do not store your medication in a closed automobile, or pack it into luggage that will be placed into a cargo area during travel. What happens if I miss a dose?

Since alprostadil is used as needed, you will not be on a dosing schedule.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I avoid while using alprostadil? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Taking this medication will not prevent you from passing a disease such as hepatitis or HIV to your sexual partner. Avoid having unprotected sex. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Alprostadil side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using alprostadil and call your doctor at once if you have a serious side effect such as:

feeling light-headed, fainting;

trouble urinating, blood in your urine;

bleeding, bruising, or swelling where you injected the medication;

a painful erection that lasts 4 hours or longer;

severe pain or irritation of your penis or urethra; or

redness, lumps, tenderness, unusual shape or curving of the erect penis.

Less serious side effects may include:

unusual discharge from your penis; or

mild pain in your penis, urethra, or testicles;

headache, dizziness;

back pain;

a rash on the skin of your penis;

itching, warmth, or numbness of your penis;

cough, stuffy nose, cold symptoms, flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Your sexual partner may also have side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.

What other drugs will affect alprostadil?

Tell your doctor about all other medicines you use, especially:

blood pressure medication; or

a blood thinner such as heparin or warfarin (Coumadin, Jantoven).

This list is not complete and other drugs may interact with alprostadil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Muse resources Muse Side Effects (in more detail)Muse Use in Pregnancy & BreastfeedingMuse Drug InteractionsMuse Support Group4 Reviews for Muse - Add your own review/rating Compare Muse with other medications Erectile Dysfunction Where can I get more information? Your pharmacist can provide more information about alprostadil.

See also: Muse side effects (in more detail)


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Caverject Impulse injectable and transurethral


Generic Name: alprostadil (injectable and transurethral) (al PROS ta dil)
Brand Names: Caverject, Caverject Impulse, Edex, Muse

What is alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis. This increases blood flow into the penis, causing an erection.

Alprostadil may also be used for purposes not listed in this medication guide.

What is the most important information I should know about alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

You should not use this medication if you are allergic to alprostadil, or if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's disease, a penile implant, or if you have been told you should not have sexual intercourse for health reasons.

Before using alprostadil, tell your doctor if you have heart disease, high blood pressure, a bleeding disorder, a history of blood clots, or a disease that could be passed in blood (such as hepatitis or HIV).

The injectable form of alprostadil is injected into the side of the penis. The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Use this medication exactly as it was prescribed for you. Using too much alprostadil can be very dangerous. The medicine comes with patient instructions for safe and effective use. Follow these directions carefully.

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Call your doctor, nurse, or pharmacist if you have any questions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes.

Seek emergency medical attention if you have a painful or prolonged erection lasting 4 hours or longer. What should I discuss with my healthcare provider before using alprostadil? You should not use this medication if you are allergic to alprostadil, or if you have:

sickle cell anemia or the sickle cell anemia trait;

leukemia;

a tumor of the bone marrow (multiple myeloma);

a curved or deformed penis;

penile fibrosis or Peyronie's disease;

if you have a penile implant; or

if you have been told you should not have sexual intercourse for health reasons.

To make sure you can safely use alprostadil, tell your doctor if you have any of these other conditions:

a history of blood clots;

heart disease, high blood pressure (hypertension);

a bleeding or blood-clotting disorder; or

a disease that could be passed in blood (such as hepatitis or HIV).

Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant or could become pregnant.

Caverject, Caverject Impulse, Edex, or Muse should not be used by women or by anyone under 18 years old. How should I use alprostadil?

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself. Wait at least 1 day after your first dose before using the medicine again.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Using too much alprostadil can be very dangerous.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different.

The injectable form of alprostadil is injected into the side of the penis.

The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections per week. Allow at least 24 hours to pass between injections.

Alprostadil comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Alprostadil injectable is a powder medicine that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medicine and the sterile liquid. The dose is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Prepare your alprostadil dose only when you are ready to use the medicine. Do not shake the mixed medicine. After mixing, the medication should be clear. Do not use the medication if it looks cloudy or has particles in it. Call your doctor for a new prescription. Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

The Caverject Impulse device uses a very thin needle, which could break easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you cannot remove the broken end, call your doctor right away.

An alprostadil injection can cause bleeding where the needle is placed. This can make it easier for your sexual partner to be exposed to your blood. Before using this medication, tell your doctor if you have a virus such as hepatitis or HIV, which can be passed to another person who comes into contact with your blood.

To be sure this medication is not causing harmful effects, your penis may need to be examined every 3 months. Visit your doctor regularly.

Storing this medicine:

Keep each urethral pellet in its original foil pouch until you are ready to use it. Store the foil pouches in the refrigerator. You may store the pouches at room temperature for up to 14 days. Store alprostadil injectable at room temperature. The 40 microgram strength of unmixed alprostadil can be stored at room temperature for up to 3 months, or until the expiration date on the label, whichever happens first. Do not expose alprostadil products to freezing or very hot temperatures. Do not store your medication in a closed automobile, or pack it into luggage that will be placed into a cargo area during travel. What happens if I miss a dose?

Since alprostadil is used as needed, you will not be on a dosing schedule.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I avoid while using alprostadil? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Taking this medication will not prevent you from passing a disease such as hepatitis or HIV to your sexual partner. Avoid having unprotected sex. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Alprostadil side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using alprostadil and call your doctor at once if you have a serious side effect such as:

feeling light-headed, fainting;

trouble urinating, blood in your urine;

bleeding, bruising, or swelling where you injected the medication;

a painful erection that lasts 4 hours or longer;

severe pain or irritation of your penis or urethra; or

redness, lumps, tenderness, unusual shape or curving of the erect penis.

Less serious side effects may include:

unusual discharge from your penis; or

mild pain in your penis, urethra, or testicles;

headache, dizziness;

back pain;

a rash on the skin of your penis;

itching, warmth, or numbness of your penis;

cough, stuffy nose, cold symptoms, flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Your sexual partner may also have side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.

What other drugs will affect alprostadil?

Tell your doctor about all other medicines you use, especially:

blood pressure medication; or

a blood thinner such as heparin or warfarin (Coumadin, Jantoven).

This list is not complete and other drugs may interact with alprostadil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Caverject Impulse resources Caverject Impulse Side Effects (in more detail)Caverject Impulse Use in Pregnancy & BreastfeedingCaverject Impulse Drug InteractionsCaverject Impulse Support Group3 Reviews for Caverject Impulse - Add your own review/rating Compare Caverject Impulse with other medications Erectile Dysfunction Where can I get more information? Your pharmacist can provide more information about alprostadil.

See also: Caverject Impulse side effects (in more detail)


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Edex Refill injectable and transurethral


Generic Name: alprostadil (injectable and transurethral) (al PROS ta dil)
Brand Names: Caverject, Caverject Impulse, Edex, Muse

What is alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis. This increases blood flow into the penis, causing an erection.

Alprostadil may also be used for purposes not listed in this medication guide.

What is the most important information I should know about alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

You should not use this medication if you are allergic to alprostadil, or if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's disease, a penile implant, or if you have been told you should not have sexual intercourse for health reasons.

Before using alprostadil, tell your doctor if you have heart disease, high blood pressure, a bleeding disorder, a history of blood clots, or a disease that could be passed in blood (such as hepatitis or HIV).

The injectable form of alprostadil is injected into the side of the penis. The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Use this medication exactly as it was prescribed for you. Using too much alprostadil can be very dangerous. The medicine comes with patient instructions for safe and effective use. Follow these directions carefully.

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Call your doctor, nurse, or pharmacist if you have any questions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes.

Seek emergency medical attention if you have a painful or prolonged erection lasting 4 hours or longer. What should I discuss with my healthcare provider before using alprostadil? You should not use this medication if you are allergic to alprostadil, or if you have:

sickle cell anemia or the sickle cell anemia trait;

leukemia;

a tumor of the bone marrow (multiple myeloma);

a curved or deformed penis;

penile fibrosis or Peyronie's disease;

if you have a penile implant; or

if you have been told you should not have sexual intercourse for health reasons.

To make sure you can safely use alprostadil, tell your doctor if you have any of these other conditions:

a history of blood clots;

heart disease, high blood pressure (hypertension);

a bleeding or blood-clotting disorder; or

a disease that could be passed in blood (such as hepatitis or HIV).

Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant or could become pregnant.

Caverject, Caverject Impulse, Edex, or Muse should not be used by women or by anyone under 18 years old. How should I use alprostadil?

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself. Wait at least 1 day after your first dose before using the medicine again.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Using too much alprostadil can be very dangerous.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different.

The injectable form of alprostadil is injected into the side of the penis.

The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections per week. Allow at least 24 hours to pass between injections.

Alprostadil comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Alprostadil injectable is a powder medicine that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medicine and the sterile liquid. The dose is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Prepare your alprostadil dose only when you are ready to use the medicine. Do not shake the mixed medicine. After mixing, the medication should be clear. Do not use the medication if it looks cloudy or has particles in it. Call your doctor for a new prescription. Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

The Caverject Impulse device uses a very thin needle, which could break easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you cannot remove the broken end, call your doctor right away.

An alprostadil injection can cause bleeding where the needle is placed. This can make it easier for your sexual partner to be exposed to your blood. Before using this medication, tell your doctor if you have a virus such as hepatitis or HIV, which can be passed to another person who comes into contact with your blood.

To be sure this medication is not causing harmful effects, your penis may need to be examined every 3 months. Visit your doctor regularly.

Storing this medicine:

Keep each urethral pellet in its original foil pouch until you are ready to use it. Store the foil pouches in the refrigerator. You may store the pouches at room temperature for up to 14 days. Store alprostadil injectable at room temperature. The 40 microgram strength of unmixed alprostadil can be stored at room temperature for up to 3 months, or until the expiration date on the label, whichever happens first. Do not expose alprostadil products to freezing or very hot temperatures. Do not store your medication in a closed automobile, or pack it into luggage that will be placed into a cargo area during travel. What happens if I miss a dose?

Since alprostadil is used as needed, you will not be on a dosing schedule.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I avoid while using alprostadil? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Taking this medication will not prevent you from passing a disease such as hepatitis or HIV to your sexual partner. Avoid having unprotected sex. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Alprostadil side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using alprostadil and call your doctor at once if you have a serious side effect such as:

feeling light-headed, fainting;

trouble urinating, blood in your urine;

bleeding, bruising, or swelling where you injected the medication;

a painful erection that lasts 4 hours or longer;

severe pain or irritation of your penis or urethra; or

redness, lumps, tenderness, unusual shape or curving of the erect penis.

Less serious side effects may include:

unusual discharge from your penis; or

mild pain in your penis, urethra, or testicles;

headache, dizziness;

back pain;

a rash on the skin of your penis;

itching, warmth, or numbness of your penis;

cough, stuffy nose, cold symptoms, flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Your sexual partner may also have side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.

What other drugs will affect alprostadil?

Tell your doctor about all other medicines you use, especially:

blood pressure medication; or

a blood thinner such as heparin or warfarin (Coumadin, Jantoven).

This list is not complete and other drugs may interact with alprostadil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Edex Refill resources Edex Refill Side Effects (in more detail) Edex Refill Use in Pregnancy & Breastfeeding Edex Refill Drug Interactions Edex Refill Support Group 0 Reviews for Edex Refill - Add your own review/rating Compare Edex Refill with other medications Erectile Dysfunction Where can I get more information? Your pharmacist can provide more information about alprostadil.

See also: Edex Refill side effects (in more detail)


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Prostin VR Pediatric injectable and transurethral


Generic Name: alprostadil (injectable and transurethral) (al PROS ta dil)
Brand Names: Caverject, Caverject Impulse, Edex, Muse

What is alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis. This increases blood flow into the penis, causing an erection.

Alprostadil may also be used for purposes not listed in this medication guide.

What is the most important information I should know about alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

You should not use this medication if you are allergic to alprostadil, or if you have sickle cell anemia, leukemia, a bone marrow tumor, a curved or deformed penis, penile fibrosis or Peyronie's disease, a penile implant, or if you have been told you should not have sexual intercourse for health reasons.

Before using alprostadil, tell your doctor if you have heart disease, high blood pressure, a bleeding disorder, a history of blood clots, or a disease that could be passed in blood (such as hepatitis or HIV).

The injectable form of alprostadil is injected into the side of the penis. The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Use this medication exactly as it was prescribed for you. Using too much alprostadil can be very dangerous. The medicine comes with patient instructions for safe and effective use. Follow these directions carefully.

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects.

Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Call your doctor, nurse, or pharmacist if you have any questions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes.

Seek emergency medical attention if you have a painful or prolonged erection lasting 4 hours or longer. What should I discuss with my healthcare provider before using alprostadil? You should not use this medication if you are allergic to alprostadil, or if you have:

sickle cell anemia or the sickle cell anemia trait;

leukemia;

a tumor of the bone marrow (multiple myeloma);

a curved or deformed penis;

penile fibrosis or Peyronie's disease;

if you have a penile implant; or

if you have been told you should not have sexual intercourse for health reasons.

To make sure you can safely use alprostadil, tell your doctor if you have any of these other conditions:

a history of blood clots;

heart disease, high blood pressure (hypertension);

a bleeding or blood-clotting disorder; or

a disease that could be passed in blood (such as hepatitis or HIV).

Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant or could become pregnant.

Caverject, Caverject Impulse, Edex, or Muse should not be used by women or by anyone under 18 years old. How should I use alprostadil?

Your first dose of this medicine will be given in your doctor's office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself. Wait at least 1 day after your first dose before using the medicine again.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Using too much alprostadil can be very dangerous.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different.

The injectable form of alprostadil is injected into the side of the penis.

The transurethral pellet is a very small suppository that is inserted into the opening of the penis (the urethra).

Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections per week. Allow at least 24 hours to pass between injections.

Alprostadil comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Alprostadil injectable is a powder medicine that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medicine and the sterile liquid. The dose is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Prepare your alprostadil dose only when you are ready to use the medicine. Do not shake the mixed medicine. After mixing, the medication should be clear. Do not use the medication if it looks cloudy or has particles in it. Call your doctor for a new prescription. Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

The Caverject Impulse device uses a very thin needle, which could break easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you cannot remove the broken end, call your doctor right away.

An alprostadil injection can cause bleeding where the needle is placed. This can make it easier for your sexual partner to be exposed to your blood. Before using this medication, tell your doctor if you have a virus such as hepatitis or HIV, which can be passed to another person who comes into contact with your blood.

To be sure this medication is not causing harmful effects, your penis may need to be examined every 3 months. Visit your doctor regularly.

Storing this medicine:

Keep each urethral pellet in its original foil pouch until you are ready to use it. Store the foil pouches in the refrigerator. You may store the pouches at room temperature for up to 14 days. Store alprostadil injectable at room temperature. The 40 microgram strength of unmixed alprostadil can be stored at room temperature for up to 3 months, or until the expiration date on the label, whichever happens first. Do not expose alprostadil products to freezing or very hot temperatures. Do not store your medication in a closed automobile, or pack it into luggage that will be placed into a cargo area during travel. What happens if I miss a dose?

Since alprostadil is used as needed, you will not be on a dosing schedule.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I avoid while using alprostadil? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Taking this medication will not prevent you from passing a disease such as hepatitis or HIV to your sexual partner. Avoid having unprotected sex. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

Alprostadil side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using alprostadil and call your doctor at once if you have a serious side effect such as:

feeling light-headed, fainting;

trouble urinating, blood in your urine;

bleeding, bruising, or swelling where you injected the medication;

a painful erection that lasts 4 hours or longer;

severe pain or irritation of your penis or urethra; or

redness, lumps, tenderness, unusual shape or curving of the erect penis.

Less serious side effects may include:

unusual discharge from your penis; or

mild pain in your penis, urethra, or testicles;

headache, dizziness;

back pain;

a rash on the skin of your penis;

itching, warmth, or numbness of your penis;

cough, stuffy nose, cold symptoms, flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Your sexual partner may also have side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.

What other drugs will affect alprostadil?

Tell your doctor about all other medicines you use, especially:

blood pressure medication; or

a blood thinner such as heparin or warfarin (Coumadin, Jantoven).

This list is not complete and other drugs may interact with alprostadil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Prostin VR Pediatric resources Prostin VR Pediatric Side Effects (in more detail) Prostin VR Pediatric Use in Pregnancy & Breastfeeding Prostin VR Pediatric Drug Interactions Prostin VR Pediatric Support Group 0 Reviews for Prostin VR Pediatric - Add your own review/rating Compare Prostin VR Pediatric with other medications Patent Ductus Arteriosus Where can I get more information? Your pharmacist can provide more information about alprostadil.

See also: Prostin VR Pediatric side effects (in more detail)


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Soluprick SQ 10 HEP


SOLUPRICK SQ 10 HEP

Solution for skin prick testing

Grass pollen, tree pollen, weed pollen, animal hair and dander and house dust mites

What You Should Know About Soluprick Sq

Please read this leaflet carefully before you start treatment with Soluprick SQ. Soluprick SQ is a solution for skin prick testing (SPT). It is used in the diagnosis of specific allergenic diseases. If you have any questions or are in any doubt about anything, please ask your doctor or nurse.

What Is The Skin Prick Testing For?

Soluprick SQ is used to check if you have an allergy to one of the following groups of allergens:

Grass pollen Tree pollen Weed pollen Animal hair and dander House dust mites

See section number 7

Before You Are Given Your Skin Prick Test Are you regularly taking Beta-blockers to control your blood pressure? Have you any skin problems in the area to be used for testing? Are you allergic to any of the ingredients in Soluprick SQ? Are you taking, antihistamines, hydroxyzine, ketotifen, tricyclic antidepressants or using steroid ointment? If the answer to any or all of the above questions is YES, TELL YOUR DOCTOR/NURSE BEFORE HE/SHE GIVES YOU SOLUPRICK SQ How Will You Be Given The Skin Prick Test? The Skin Prick Test is usually carried out on the inner side of the forearm. Alternatively the test can be done on your back. Your skin must be dry and clean and may be disinfected with alcohol by the nurse or doctor Test preparations and the controls are applied in droplets on the skin at an appropriate distance from each other (a numbered tape may be used). The top layer of the skin is pierced by the doctor/nurse with an ALK lancet through the droplets. The reaction is read after 15 minutes. A positive reaction is a pale small raised swelling or weal with a red edge. After You Have Been Given The Skin Prick Test

Normally a Skin Prick Test does not cause any problems but occasionally some people may get side effects such as:

A continuously spreading weal may be formed at the site during the first 10-20 minutes after application of the allergen. Widespread swelling and redness may happen 6-24 hours after the application of the allergen.

If you experience any of these side effects, and they stay or become troublesome, tell your doctor or pharmacist.

If you get any other unusual or unexpected side effect, you should tell your doctor or pharmacist at once.

Anaphylactic reaction

In extremely rare cases an anaphylactic reaction (a severe reaction throughout the body that is recognised by difficulty in breathing, fainting, itching, and weals) may develop after a few seconds or minutes. For this reason an emergency kit with a ‘ready for use’ adrenalin syringe will always be available.

TELL YOUR DOCTOR/NURSE IMMEDIATELY IF YOU FEEL ANY OF THESE CHANGES. He or she will be able to give you the right treatment at once to make you feel well.

How Should The Skin Prick Test Be Stored? The clinic/hospital will store the Skin Prick Test, solution. This medicine should be kept in a refrigerator (between 2?C and 8?C) out of the reach and sight of children, as the medicine could harm them. Do not freeze the solution. Keep the vials in the outer carton to protect it from light. Do not use the skin prick test solution after the expiry date, which is printed on the carton and label. What Is In The Medicine?

Soluprick SQ is a solution for skin prick testing that contains an extract of specific allergen. The allergen is the substance that causes the allergic disease. Soluprick SQ also contains the inactive ingredients, disodium phosphate, sodium dihydrogen phosphate, phenol, sodium chloride, glycerol and water for injections.

The following individual allergens are available:

Grass pollen: Meadow Foxtail, Cock’s Foot, Meadow Fescue, Perennial Ryegrass, Timothy Grass, Kentucky Blue Grass, Cultivated Rye.

Tree pollen: European Alder, Grey Alder, Silver Birch, Hazel

Weed pollen: Mugwort, Pellitory of the Wall, Upright Pellitory.

Animal hair and dander: Horse Dander, Dog Hair, Cat Hair

House dust mites: Dermatophagoides farinae, Dermatophagoides pteronyssinus

Each single allergen is provided in a 2 ml glass vial.

The strength of the products is 10 HEP

The biological activity of Soluprick SQ is related to the reaction in the skin of an allergic patient measured relative to a histamine dihydrochloride solution.

Manufacturer And Product Licence Holder Product Licence Holder: ALK-Abell? A/S B?ge All? 6-8 DK-2970 H?rsholm Denmark Manufacturer: ALK-Abell? S.A. Miguel Fleta 19 E-28037 Madrid Spain Distributor ALK-Abell? Ltd. 1 Tealgate Hungerford Berkshire RG17 OYT United Kingdom Tel:01488 686 016 0. Date On Which The Package Leaflet Was Last Revised

June 2007

1. Further Information Allergy UK Tel:01322 619 898 Email:www.allergyuk.org
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Anadrol-50


Generic Name: oxymetholone (OKS ee METH oh lone)
Brand Names: Anadrol-50

What is Anadrol-50 (oxymetholone)?

Oxymetholone is an anabolic steroid, which is a man-made form of a hormone similar to testosterone.

Oxymetholone is used to treat certain types of anemia (lack of red blood cells), including aplastic anemia, myelofibrosis, or hypoplastic anemia caused by chemotherapy.

Oxymetholone may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Anadrol-50 (oxymetholone)? This medication can cause birth defects. Do not use if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment. You should not use this medication if you are allergic to oxymetholone, or if you have prostate cancer, male breast cancer, female breast cancer with high levels of calcium in the blood, severe liver or kidney disease, or if you are pregnant.

Before using oxymetholone, tell your doctor if you have liver or kidney disease, heart disease, congestive heart failure, high cholesterol or triglycerides, coronary artery disease, or an enlarged prostate.

Call your doctor at once if you have a serious side effect such as swelling, rapid weight gain, increased or ongoing erection of the penis, changes in skin color, urination problems, or signs of liver damage (nausea, vomiting, stomach pain, loss of appetite, and jaundice (yellowing of the skin or eyes). Women receiving oxymetholone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor as soon as possible if you notice increased acne, changes in menstrual periods, a deepened voice, male pattern baldness or hair growth, an enlarged clitoris, or changes in your sex drive.

To be sure oxymetholone is helping your condition and is not causing harmful effects on your liver, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

It may take up to 6 months of using this medicine before your symptoms improve. Tell your doctor if your symptoms do not improve after 3 months of treatment. What should I discuss with my health care provider before taking Anadrol-50 (oxymetholone)? You should not use this medication if you are allergic to oxymetholone, or if you have:

prostate cancer;

male breast cancer;

female breast cancer with high levels of calcium in the blood;

severe liver disease;

severe kidney disease; or

if you are pregnant.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using oxymetholone, tell your doctor if you have:

liver disease;

kidney disease;

heart disease, congestive heart failure;

high cholesterol or triglycerides;

coronary artery disease (atherosclerosis); or

an enlarged prostate.

FDA pregnancy category X. This medication can cause birth defects. Do not use oxymetholone if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medication. It is not known whether oxymetholone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Children being treated with oxymetholone may need x-ray examinations every 6 months to make sure the medication is not causing harmful effects on bone growth. Oxymetholone will not enhance athletic performance and should not be used for that purpose or shared with another person. How should I take Anadrol-50 (oxymetholone)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

To be sure oxymetholone is helping your condition and is not causing harmful effects on your liver, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using oxymetholone.

It may take up to 6 months of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 3 months of treatment.

Once your condition is under control, you may be able to stop taking oxymetholone. However, some people must continue to use at least a small amount of the medicine to keep their red blood cells from getting too low. You may need to take oxymetholone for the rest of your life. Follow your doctor's instructions.

Anemia is often treated with a combination of different drugs, including antibiotics and vitamin or mineral supplements. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

Store oxymetholone at room temperature away from moisture and heat. Keep track of how many pills have been used from each new bottle of this medicine. Anabolic steroids are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

See also: Anadrol-50 dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention if you think you have received too much of this medicine.

An overdose of oxymetholone is not expected to produce life-threatening symptoms.

What should I avoid while taking Anadrol-50 (oxymetholone)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using oxymetholone.

Anadrol-50 (oxymetholone) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

swelling, rapid weight gain;

increased or ongoing erection of the penis;

changes in skin color;

urination problems; or

nausea, vomiting, stomach pain, loss of appetite, and jaundice (yellowing of the skin or eyes).

Women receiving oxymetholone may develop male characteristics, which could be irreversible if treatment is continued. Call your doctor as soon as possible if you notice any of these side effects:

acne;

changes in your menstrual periods;

hoarse or deepened voice;

male-pattern hair growth (such as on the chin or chest);

male pattern baldness;

enlarged clitoris; or

increase or decrease in sex drive.

Less serious side effects may include:

breast swelling in men;

feeling restless or excited;

sleep problems (insomnia); or

diarrhea.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Anadrol-50 (oxymetholone)?

The following drugs can interact with oxymetholone. Tell your doctor if you are using any of these:

a blood thinner such as warfarin (Coumadin); or

insulin or diabetes medication you take by mouth.

This list is not complete and there may be other drugs that can interact with oxymetholone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Anadrol-50 resources Anadrol-50 Side Effects (in more detail) Anadrol-50 Dosage Anadrol-50 Use in Pregnancy & Breastfeeding Drug Images Anadrol-50 Drug Interactions Anadrol-50 Support Group 0 Reviews for Anadrol-50 - Add your own review/rating Anadrol-50 MedFacts Consumer Leaflet (Wolters Kluwer) Oxymetholone Professional Patient Advice (Wolters Kluwer) Compare Anadrol-50 with other medications Anemia Where can I get more information? Your pharmacist can provide more information about oxymetholone.

See also: Anadrol-50 side effects (in more detail)


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papaverine Injection


pa-PAV-er-een

Available Dosage Forms:

Solution Injectable

Therapeutic Class: Peripheral Vasodilator

Uses For papaverine

Papaverine belongs to the group of medicines called vasodilators. Vasodilators cause blood vessels to expand, thereby increasing blood flow. Papaverine is used to produce erections in some men with erectile dysfunction. When papaverine is injected into the penis (intracavernosal), it increases blood flow to the penis, which results in an erection.

Papaverine injection should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

Papaverine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, papaverine is used in certain patients with the following medical conditions:

Low doses of a three-drug combination of papaverine, phentolamine, and alprostadil as an injection may be used to treat erectile dysfunction. Before Using papaverine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For papaverine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to papaverine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. Although there is no specific information comparing the use of papaverine for erectile dysfunction in the elderly with use in other age groups, papaverine is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking papaverine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using papaverine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ginkgo Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of papaverine. Make sure you tell your doctor if you have any other medical problems, especially:

Bleeding problems—These conditions increase the risk of bleeding at the place of injection. Liver disease—Papaverine can cause liver damage when it is given in ways that allow it to get into the bloodstream (by mouth or by injection into a muscle, a vein, or an artery); when papaverine is given by intracavernosal injection, liver damage is much less likely because the medicine enters the bloodstream very slowly. Priapism (history of) or Sickle cell disease—Patients with these conditions have an increased risk of priapism (erection lasting longer than 4 hours) while using papaverine. Proper Use of papaverine

To give papaverine injection:

Cleanse the injection site with alcohol. Using a sterile needle, inject the medicine slowly and directly into the base of the penis as instructed by your doctor. Papaverine should not be injected just under the skin. The injection is usually not painful, although you may feel some tingling in the tip of your penis. If the injection is very painful or you notice bruising or swelling at the place of injection, that means you have been injecting the medicine under the skin. Stop, withdraw the needle, and reposition it properly before continuing with the injection. After you have completed the injection, put pressure on the place of injection to prevent bruising. Then massage your penis as instructed by your doctor. This helps the medicine spread to all parts of the penis, so that it will work better.

papaverine usually begins to work in about 10 minutes. You should attempt intercourse within 2 hours after injecting the medicine.

Dosing

The dose of papaverine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of papaverine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For injection dosage form: For the treatment of erectile dysfunction: Adults—30 to 60 milligrams (mg) injected very slowly into the area of your penis as directed by your doctor. Allow one or two minutes to completely inject the dose. Do not inject more than one dose in a day. Also, do not use papaverine more than two days in a row or more than three times a week. Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using papaverine

Use papaverine injection exactly as directed by your doctor . Do not use more of it and do not use it more often than ordered. If too much is used, the erection may become so strong that it lasts too long and does not reverse when it should. This condition is called priapism, and it can be very dangerous. If the effect is not reversed, the blood supply to the penis may be cut off and permanent damage may occur.

Contact your doctor immediately if the erection lasts for longer than 4 hours or if it becomes painful. This may be a sign of priapism and must be treated right away to prevent permanent damage.

If you notice bleeding at the site when you inject papaverine, put pressure on the spot until the bleeding stops. If it doesn't stop, check with your doctor.

It is important for you to examine your penis regularly. Check with your doctor if you find a lump where the medicine has been injected or if you notice that your penis is becoming curved. These may be signs that unwanted tissue is growing (called fibrosis), which should be seen by your doctor.

papaverine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Dizziness erection continuing for more than 4 hours, or painful erection lumps in the penis

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common Bruising or bleeding at place of injection burning (mild) along penis difficulty in ejaculating swelling at place of injection

Papaverine injected into the penis may cause tingling at the tip of the penis. This is no cause for concern.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: papaverine Injection side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More papaverine Injection resources Papaverine Injection Side Effects (in more detail) Papaverine Injection Use in Pregnancy & Breastfeeding Drug Images Papaverine Injection Drug Interactions Papaverine Injection Support Group 0 Reviews · Be the first to review/rate this drug
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Viagra


Pronunciation: sil-DEN-a-fil
Generic Name: Sildenafil
Brand Name: Viagra
Viagra is used for:

Treating erectile dysfunction (ED). It may also be used for other conditions as determined by your doctor.

Viagra is a phosphodiesterase type 5 (PDE5) inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection.

Do NOT use Viagra if: you are allergic to any ingredient in Viagra you have been advised by your doctor to avoid sexual activity because of heart problems you are taking nitrates (eg, isosorbide, nitroglycerin) in any form (eg, tablet, capsule, patch, ointment), or nitroprusside you use certain recreational drugs called "poppers" (eg, amyl nitrate or nitrite, butyl nitrate or nitrite) you take another PDE5 inhibitor (eg, tadalafil, vardenafil) or another medicine that contains sildenafil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Viagra:

Some medical conditions may interact with Viagra. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a deformed penis (eg, cavernosal fibrosis, Peyronie disease), blood cell problems (eg, leukemia, multiple myeloma, sickle cell anemia), or any other condition that may increase the risk of a prolonged erection (priapism) if you have a history of a prolonged (more than 4 hours) or painful erection (priapism) if you have a history of certain eye problems (eg, macular degeneration, optic neuropathy, retinitis pigmentosa, sudden vision loss in one or both eyes) or hearing problems (eg, ringing in the ears, decreased hearing, hearing loss) if you have a history of liver or kidney problems, lung problems (eg, pulmonary veno-occlusive disease), high or low blood pressure, ulcers, bleeding problems, heart problems (eg, angina, aortic stenosis, heart failure, irregular heartbeat), or blood vessel problems if you have a history of heart attack, stroke, or life-threatening irregular heartbeat, especially within the past 6 months

Some MEDICINES MAY INTERACT with Viagra. Tell your health care provider if you are taking any other medicines, especially any of the following:

Alpha-blockers (eg, doxazosin), medicines for high blood pressure, nitrates (eg, isosorbide, nitroglycerin), or nitroprusside because severe low blood pressure with dizziness, lightheadedness, and fainting may occur Azole antifungals (eg, itraconazole, ketoconazole), H2 antagonists (eg, cimetidine), HIV protease inhibitors (eg, ritonavir, saquinavir), macrolide antibiotics (eg, erythromycin), narcotic analgesics (eg, dihydrocodeine), or telithromycin because they may increase the risk of Viagra's side effects Bosentan or rifampin because they may decrease Viagra's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Viagra may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Viagra:

Use Viagra as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with Viagra. Talk to your pharmacist if you have questions about this information. Take Viagra by mouth with or without food. Viagra may not work as quickly if you take it with a high-fat meal. Viagra is usually taken about 1 hour before sexual activity; however, it may be taken anywhere from 4 hours to a half hour before sexual activity. Talk with your doctor about the best way to take Viagra. Do NOT take more than the recommended dose or take it more often than once daily, or as directed by your doctor. If you miss a dose of Viagra and you still intend to engage in sexual activity, take it as soon as you remember. Continue to take it as directed by your doctor.

Ask your health care provider any questions you may have about how to use Viagra.

Important safety information: Viagra may cause dizziness, drowsiness, fainting, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Viagra with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Viagra may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Patients with heart problems who take Viagra may be at increased risk for heart-related side effects, including heart attack or stroke. Symptoms of a heart attack may include chest, shoulder, neck, or jaw pain; numbness of an arm or leg; severe dizziness, headache, nausea, stomach pain, or vomiting; fainting; or vision changes. Symptoms of a stroke may include confusion, vision or speech changes, one-sided weakness, or fainting. Contact your doctor or seek medical attention right away if you experience these symptoms. Viagra may rarely cause a prolonged (eg, more than 4 hours) or painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if you have an erection that lasts more than 4 hours. Viagra does not stop the spread of HIV or other sexually transmitted diseases (STDs) to others through sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection or an STD. Viagra will not prevent pregnancy. If your partner may become pregnant and you wish to avoid pregnancy, be sure to use an effective form of birth control. Viagra may uncommonly cause mild, temporary vision changes (eg, blurred vision, sensitivity to light, blue/green color tint to vision). Contact your doctor if vision changes persist or are severe. Rarely, an eye problem called nonarteritic anterior ischemic optic neuropathy (NAION) has been reported in patients who took Viagra. This may lead to decreased vision or permanent loss of vision in some cases. If you notice a sudden decrease in vision or loss of vision in one or both eyes, contact your doctor right away. Sudden decreases in hearing and loss of hearing have been reported in some patients who have taken Viagra. Sometimes they also noticed ringing in the ears or dizziness. If you notice a sudden decrease or loss of hearing, contact your doctor right away. Do not use other medicines or treatments for ED while you are taking Viagra without first checking with your doctor. Use Viagra with caution in the ELDERLY; they may be more sensitive to its effects. Viagra is not recommended for use in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: Viagra is not approved for use in women. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Viagra while you are pregnant. It is not known if Viagra is found in breast milk. If you are or will be breast-feeding while you use Viagra, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Viagra:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; flushing; headache; heartburn; stuffy nose; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; memory loss; numbness of an arm or leg; one-sided weakness; painful or prolonged erection; ringing in the ears; seizure; severe or persistent dizziness; severe or persistent vision changes; sudden decrease or loss of hearing; sudden decrease or loss of vision in one or both eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Viagra side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; fainting; prolonged erection; severe dizziness.

Proper storage of Viagra:

Store Viagra at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Viagra out of the reach of children and away from pets.

General information: If you have any questions about Viagra, please talk with your doctor, pharmacist, or other health care provider. Viagra is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Viagra. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Viagra resources Viagra Side Effects (in more detail)Viagra DosageViagra Use in Pregnancy & BreastfeedingDrug ImagesViagra Drug InteractionsViagra Support Group44 Reviews for Viagra - Add your own review/rating Viagra Prescribing Information (FDA) Viagra Advanced Consumer (Micromedex) - Includes Dosage Information Viagra Consumer Overview Revatio Prescribing Information (FDA) Revatio Consumer Overview Sildenafil Citrate Monograph (AHFS DI) Compare Viagra with other medications Erectile DysfunctionSexual Dysfunction, SSRI Induced
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tadalafil


Generic Name: tadalafil (ta DAL a fil)
Brand Names: Adcirca, Cialis

What is tadalafil?

Tadalafil relaxes muscles and increases blood flow to particular areas of the body.

Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of sildenafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Tadalafil may also be used for purposes not listed in this medication guide.

What is the most important information I should know about tadalafil? Do not take tadalafil if you are allergic to it, or if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. If you become dizzy or nauseated during sexual activity, or if you have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of tadalafil. Do not take tadalafil more than once a day. Allow 24 hours to pass between doses. Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

Tadalafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking tadalafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old. It is not clear whether tadalafil is the actual cause of vision loss.

Stop using tadalafil and get emergency medical help if you have sudden vision loss. What should I discuss with my healthcare provider before taking tadalafil? You should not take tadalafil if you are allergic to it.

Tadalafil should not be used together with nitrate medication, such as nitroglycerin (Nitro Dur, Nitrolingual, Nitrostat, Transderm Nitro, and others), isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medicine for chest pain or heart problems can cause a sudden and serious decrease in blood pressure.

To make sure you can safely take tadalafil, tell your doctor if you have any of these other conditions:

heart disease or heart rhythm problems;

a recent heart attack (within the past 90 days);

a recent history (in the past 6 months) of a stroke, or congestive heart failure;

angina (chest pain), high or low blood pressure;

liver disease;

kidney disease (or if you are on dialysis);

a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;

a bleeding disorder such as hemophilia;

a stomach ulcer;

retinitis pigmentosa (an inherited condition of the eye);

a physical deformity of the penis (such as Peyronie's disease); or

if you have been told you should not have sexual intercourse for health reasons.

Tadalafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking tadalafil, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old.

It is not clear whether tadalafil is the actual cause of vision loss. Stop using tadalafil and get emergency medical help if you have sudden vision loss. FDA pregnancy category B. Tadalafil is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Adcirca. It is not known whether tadalafil passes into breast milk or if it could harm a nursing baby. Do not use Adcirca without telling your doctor if you are breast-feeding a baby. How should I take tadalafil?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Tadalafil can be taken with or without food.

Do not break or split a Cialis tablet. Swallow it whole.

Cialis is usually taken only once per day. Follow your doctor's instructions. For erectile dysfunction, take the medicine just before sexual activity but not more than once per day.

Cialis can help achieve an erection when sexual stimulation occurs. An erection will not occur just by taking a pill. Follow your doctor's instructions.

Adcirca is usually taken once per day. Follow your doctor's instructions. Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.

Do not take tadalafil more than once a day. Allow 24 hours to pass between doses. If you take the medication daily, take it at the same time each day. Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis. Store at room temperature away from moisture and heat.

See also: Tadalafil dosage (in more detail)

What happens if I miss a dose?

If tadalafil is used as needed, you are not likely to be on a dosing schedule.

If you take tadalafil every day and you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

What should I avoid while taking tadalafil? Drinking alcohol can increase certain side effects of tadalafil.

Grapefruit and grapefruit juice may interact with tadalafil and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Avoid using other medicines to treat erectile dysfunction, such as sildenafil (Viagra) or vardenafil (Levitra) while you are taking tadalafil. Tadalafil side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. If you become dizzy or nauseated during sexual activity, or if you have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. You could be having a serious side effect of tadalafil. Stop using tadalafil and call your doctor at once if you have any of these serious side effects:

changes in vision or sudden vision loss;

ringing in your ears, or sudden hearing loss;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

irregular heartbeat;

shortness of breath, swelling in your hands or feet;

seizure (convulsions);

feeling light-headed, fainting; or

penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

redness or warmth in your face, neck, or chest;

cold symptoms such as stuffy nose, sneezing, or sore throat;

headache;

memory problems;

diarrhea, upset stomach; or

muscle pain, back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Tadalafil Dosing Information

Usual Adult Dose for Erectile Dysfunction:

Erectile dysfunction:
10 mg orally taken prior to anticipated sexual activity. The maximum recommended dosing frequency is once per day in most patients.
Alternatively, 2.5 mg orally once daily, without regard to timing of sexual activity. May increase to 5 mg orally once daily based on efficacy and tolerability.
Erectile dysfunction and benign prostatic hyperplasia together:
5 mg orally taken at approximately the same time every day.

Usual Adult Dose for Pulmonary Hypertension:

40 mg orally once daily, with or without food. Dividing the dose (40 mg) over the course of the day is not recommended.

Usual Adult Dose for Benign Prostatic Hyperplasia:

Benign prostatic hyperplasia and benign prostatic hyperplasia with erectile dysfunction:
5 mg orally taken at approximately the same time every day.

What other drugs will affect tadalafil?

Tell your doctor about all other medicines you use, especially:

rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, Rifater, Rifamate), or rifapentine (Priftin);

an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);

antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);

an antidepressant such as nefazodone;

a barbiturate such as phenobarbital (Solfoton);

drugs to treat high blood pressure or a prostate disorder, such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax);

heart or blood pressure medication such as diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan); or

HIV or AIDS medications such as darunavir (Prezista), efavirenz (Sustiva), etravirine (Intelence), nevirapine (Viramune), fosamprenavir (Lexiva), indinavir (Crixivan), ritonavir (Norvir, Kaletra), and others; or

seizure medications such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), and others.

This list is not complete and other drugs may interact with tadalafil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More tadalafil resources Tadalafil Side Effects (in more detail) Tadalafil Dosage Tadalafil Use in Pregnancy & Breastfeeding Tadalafil Drug Interactions Tadalafil Support Group 103 Reviews for Tadalafil - Add your own review/rating tadalafil Advanced Consumer (Micromedex) - Includes Dosage Information Tadalafil MedFacts Consumer Leaflet (Wolters Kluwer) Tadalafil Monograph (AHFS DI) Tadalafil Professional Patient Advice (Wolters Kluwer) Adcirca Prescribing Information (FDA) Adcirca Consumer Overview Adcirca MedFacts Consumer Leaflet (Wolters Kluwer) Cialis Prescribing Information (FDA) Cialis Consumer Overview Compare tadalafil with other medications Benign Prostatic Hyperplasia Erectile Dysfunction Pulmonary Arterial Hypertension Where can I get more information? Your pharmacist can provide more information about tadalafil.

See also: tadalafil side effects (in more detail)


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phentolamine Injection


fen-TOL-a-meen

Commonly used brand name(s)

In the U.S.

OraVerse Regitine

Available Dosage Forms:

Solution Injectable Powder for Solution

Therapeutic Class: Antihypertensive

Pharmacologic Class: Alpha-Adrenergic Blocker

Uses For phentolamine

Phentolamine given by injection causes blood vessels to expand, thereby increasing blood flow. When injected into the penis (intracavernosal), it increases blood flow to the penis, which results in an erection.

phentolamine should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

Phentolamine may also be used to reverse the effects of an anesthetic medicine in soft tissues, such as the lips and tongue. It may be used to help quickly restore normal sensation and function in patients who have received local dental anesthesia .

Phentolamine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, phentolamine is used in certain patients with the following medical conditions:

Low doses of a three-drug combination of phentolamine, papaverine, and alprostadil as an injection may be used to treat erectile dysfunction. Before Using phentolamine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For phentolamine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to phentolamine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of phentolamine for the reversal of soft-tissue anesthesia in children younger than 6 years of age. Safety and efficacy have not been established .

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. Although there is no specific information comparing the use of phentolamine for erectile dysfunction in the elderly, it is not expected to cause different side effects or problems in older people than it does in younger adults.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking phentolamine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using phentolamine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Tadalafil

Using phentolamine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol Alprenolol Atenolol Betaxolol Bevantolol Bisoprolol Bucindolol Carteolol Carvedilol Celiprolol Dilevalol Esmolol Labetalol Levobunolol Mepindolol Metipranolol Metoprolol Nadolol Nebivolol Oxprenolol Penbutolol Pindolol Propranolol Sotalol Talinolol Tertatolol Timolol Vardenafil Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of phentolamine. Make sure you tell your doctor if you have any other medical problems, especially:

Bleeding problems—These conditions increase the risk of bleeding at the place of injection. Priapism (history of) or Sickle cell disease—Patients with these conditions have an increased risk of priapism (erection lasting longer than 4 hours) while using phentolamine. Proper Use of phentolamine

To give the injection:

Cleanse the injection site with alcohol. Using a sterile needle, inject the medicine slowly and directly into the base of the penis as instructed by your doctor. It should not be injected just under the skin. The injection is usually not painful, although you may feel some tingling in the tip of your penis. If the injection is very painful or you notice bruising or swelling at the place of injection, that means you are injecting the medicine under the skin. Stop, withdraw the needle, and reposition it properly before continuing with the injection. After you have completed the injection, put pressure on the place of injection to prevent bruising. Then massage your penis as instructed by your doctor. This helps the medicine spread to all parts of the penis, so that it will work better.

phentolamine usually begins to work in about 10 minutes. You should attempt intercourse within 2 hours after injecting the medicine.

To reverse the effects of a soft-tissue anesthetic medicine, a dentist or other trained health professional will give you phentolamine. phentolamine is usually injected at the same spot where you have received the local dental anesthesia .

Dosing

The dose of phentolamine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of phentolamine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For injection dosage form: For the treatment of impotence: Adults— 0.5 to 1 milligram (mg) injected very slowly into the area of your penis as directed by your doctor. Allow one or two minutes to completely inject the dose. Do not inject more than one dose in a day. Also, do not use phentolamine more than two days in a row or more than three times a week. Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using phentolamine

Use the injection exactly as directed by your doctor. Do not use more of it and do not use it more often than ordered. If too much is used, the erection may become so strong that it lasts too long and does not reverse when it should. This condition is called priapism, and it can be very dangerous. If the effect is not reversed, the blood supply to the penis may be cut off and permanent damage may occur.

Contact your doctor immediately if the erection lasts for longer than 4 hours or if it becomes painful. This may be a sign of priapism and must be treated right away to prevent permanent damage.

If you notice bleeding at the site when you inject the medicine, put pressure on the spot until the bleeding stops. If it doesn't stop, check with your doctor.

It is important for you to examine your penis regularly. Check with your doctor if you find a lump where the medicine has been injected or if you notice that your penis is becoming curved. These may be signs that unwanted tissue is growing (called fibrosis), which should be seen by your doctor.

phentolamine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Dizziness erection continuing for more than 4 hours, or painful erection lumps in the penis

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common or rare Bruising or bleeding at place of injection burning (mild) along penis difficulty in ejaculating swelling at place of injection

Phentolamine injected into the penis may cause tingling at the tip of the penis. This is no cause for concern.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: phentolamine Injection side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More phentolamine Injection resources Phentolamine Injection Side Effects (in more detail) Phentolamine Injection Use in Pregnancy & Breastfeeding Phentolamine Injection Drug Interactions Phentolamine Injection Support Group 0 Reviews for Phentolamine Injection - Add your own review/rating Compare phentolamine Injection with other medications Dermal Necrosis, Treatment Pheochromocytoma Pheochromocytoma Diagnosis Reversal of Anesthesia
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Cialis 5mg film-coated tablets


CIALIS 5 mg film-coated tablets

tadalafil

Read all of this leaflet carefully before you start taking this medicine. Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What CIALIS is and what it is used for 2. Before you take CIALIS 3. How to take CIALIS 4. Possible side effects 5. How to store CIALIS 6. Further information What Cialis Is And What It Is Used For

CIALIS is a treatment for men with erectile dysfunction. This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity.

CIALIS belongs to a group of medicines called phosphodiesterase type 5 inhibitors. Following sexual stimulation CIALIS works by helping the blood vessels in your penis to relax, allowing the flow of blood into your penis. The result of this is improved erectile function. CIALIS will not help you if you do not have erectile dysfunction.

It is important to note that CIALIS does not work if there is no sexual stimulation. You and your partner will need to engage in foreplay, just as you would if you were not taking a medicine for erectile dysfunction.

Before You Take Cialis Do not take CIALIS if you are allergic (hypersensitive) to tadalafil or any of the other ingredients of CIALIS. if you are taking any form of organic nitrate or nitric oxide donors such as amyl nitrite. This is a group of medicines (“nitrates”) used in the treatment of angina pectoris (“chest pain”). CIALIS has been shown to increase the effects of these medicines. If you are taking any form of nitrate or are unsure tell your doctor. if you have serious heart disease or have had a recent heart attack. if you have had a recent stroke. if you have low blood pressure or uncontrolled high blood pressure. if you have ever had loss of vision because of non-arteritic anterior ischemic optic neuropathy (NAION), a condition sometimes described as “stroke of the eye”. Take special care with CIALIS

Be aware that sexual activity carries a possible risk to patients with heart disease because it puts an extra strain on your heart. If you have a heart problem you should tell your doctor.

The following are reasons why CIALIS may also not be suitable for you. If any of them apply to you, talk to your doctor before you take the medicine:

You have sickle cell anaemia (an abnormality of red blood cells), multiple myeloma (cancer of the bone marrow), leukaemia (cancer of the blood cells) or any deformation of your penis. You have a serious liver problem. You have a severe kidney problem.

It is not known if CIALIS is effective in patients who have undergone pelvic surgery or radical non-nerve-sparing prostatectomy

If you experience sudden decrease or loss of vision, stop taking CIALIS and contact your doctor immediately.

CIALIS is not intended for use by women or by adolescents under the age of 18.

Using other medicines

Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, because they might interact.

This is particularly important if you are treated with nitrates as you should not take CIALIS if you are taking these medicines.

A type of medicine called an alpha blocker is sometimes used to treat high blood pressure and enlarged prostate. Tell your doctor if you are being treated for either of these conditions or if you take other medicines to treat high blood pressure.

If you are taking medicines that can inhibit an enzyme called CYP3A4 (for example ketoconazole or protease inhibitors for treatment of HIV) the frequency of side effects might increase.

Do not take CIALIS with other medicines if your doctor tells you that you may not.

You should not use CIALIS together with any other treatments for erectile dysfunction.

Taking CIALIS with food and drink

You may take CIALIS with or without food.

Information on the effect of alcohol is in section 3.

Driving and using machines

Some men taking CIALIS in clinical studies have reported dizziness. Check carefully how you react to the medicines before driving or using any machinery.

Important information about some of the ingredients of CIALIS:

CIALIS contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

How To Take Cialis

Always take CIALIS exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.

Once a day dosing of CIALIS may be useful to men who anticipate having sexual activity two or more times per week. The recommended dose is one 5 mg tablet taken once a day at approximately the same time of the day. Your doctor may adjust the dose to 2.5 mg based on your response to CIALIS. CIALIS tablets are for oral use. Swallow the tablet whole with some water. You may take CIALIS with or without food.

When taken once a day CIALIS allows you to obtain an erection, when sexually stimulated, at any time point during the 24 hours of the day. It is important to note that CIALIS does not work if there is no sexual stimulation. You and your partner will need to engage in foreplay, just as you would if you were not taking a medicine for erectile dysfunction.

Drinking alcohol may affect your ability to get an erection. Drinking alcohol may temporarily lower your blood pressure. If you have taken or are planning to take CIALIS, avoid excessive drinking (blood alcohol level of 0.08% or greater), since this may increase the risk of dizziness when standing up.

You should NOT take CIALIS more than once a day.

If you take more CIALIS than you should

Tell your doctor.

If you forget to take CIALIS

Do not take a double dose to make up for a forgotten tablet.

If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible Side Effects

Like all medicines, CIALIS can cause side effects, although not everybody gets them. These effects are normally mild to moderate in nature.

In this leaflet, when a side effect is described as “very common” this means that it has been reported in at least 1 in 10 patients taking the medicine. When a side effect is described as “common” this means that it has been reported in more than 1 in every 100 patients but less than 1 in every 10 patients. When a side effect is described as “uncommon”, this means it has been reported in more than 1 in every 1,000 patients, but less than 1 in every 100 patients. When a side effect is described as “rare”, this means it has been reported in more than 1 in every 10,000 patients, but less than 1 in every 1,000 patients.

Very commonly reported side effects in patients taking CIALIS were headache and indigestion.

Commonly reported side effects in patients taking CIALIS include back pain, muscle aches, facial flushing, nasal congestion, dizziness, pounding heartbeat sensation, abdominal pain and reflux.

Uncommon side effects are allergic reactions including rashes and hives, blurred vision, swelling of the eyelids, eye pain, red eyes, increased sweating, nose bleeds, a fast heart rate, high blood pressure, low blood pressure and chest pain. In case of chest pain occurring during or after sexual activity you should NOT use nitrates but you should seek immediate medical assistance.

Rare side effects in patients taking CIALIS include fainting, migraine and swelling of the face.

In rare instances it is possible that a prolonged and possibly painful erection may occur after taking CIALIS. If you have such an erection, which lasts continuously for more than 4 hours, you should contact a doctor immediately.

Heart attack and stroke have also been reported rarely in men taking CIALIS. Most, but not all of these men had known heart problems before taking this medicine. It is not possible to determine whether these events were directly related to CIALIS.

Partial, sudden, temporary, or permanent decrease or loss of vision in one or both eyes has been rarely reported.

Some additional side effects have been reported in men taking CIALIS that were not seen in clinical trials and their incidence is unknown. These include seizures and passing memory loss, some disorders affecting blood flow to the eyes, irregular heartbeats and angina, serious skin rashes and sudden cardiac death. Sudden decrease or loss of hearing has been reported.

Effects were seen in one animal species that might indicate impairment of fertility. Subsequent studies in man suggest that this effect is unlikely in humans, although a decrease in sperm concentration was seen in some men.

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

How To Store Cialis

Keep out of the reach and sight of children.

Do not use CIALIS after the expiry date stated on the carton and blister.

Store in the original package in order to protect from moisture. Do not store above 25°C.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Further Information What CIALIS contains

The active substance is tadalafil. Each tablet contains 5 mg of tadalafil.

The other ingredients are:

Tablet core: lactose monohydrate, croscarmellose sodium, hydroxypropylcellulose, microcrystalline cellulose, sodium laurilsulfate, magnesium stearate.

Film-coat: lactose monohydrate, hypromellose, triacetin, titanium dioxide (E171), iron oxide yellow (E172), talc.

What CIALIS looks like and contents of the pack

CIALIS 5 mg strength comes as light yellow film-coated tablets. They are in the shape of almonds and have "C 5" marked on one side.

CIALIS 5 mg is available in blister packs containing 14 or 28 tablets.

Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder:

Eli Lilly Nederland B.V. Grootslag 1-5 NL-3991 RA Houten The Netherlands

Manufacturer:

Eli Lilly and Company Ltd Kingsclere Road Basingstoke Hampshire RG21 6XA United Kingdom


Lilly S.A. Avda. de la Industria 30 28108 Alcobendas Madrid Spain

For any information about this medicinal product, please contact the local representative of the Marketing Authorisation Holder.

United Kingdom Eli Lilly and Company Limited Tel:+44-(0) 1256 315999

This leaflet was last approved in March 2008.

Detailed information on this medicine is available on the European Medicines Agency (EMEA) web site: http://www.emea.europa.eu


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Triveen-CF NAC


Pronunciation: meth-ill-FOE-late/meth-ill-koe-BAL-a-min/a-se-teel-SIS-teen
Generic Name: L-Methylfolate/Methylcobalamin/N-Acetylcysteine
Brand Name: Examples include Cerefolin with NAC and Triveen-CF NAC
Triveen-CF NAC is used for:

Supplying nutritional requirements of certain patients with neurovascular oxidative stress or high blood levels of homocysteine. It may also be used for other conditions as determined by your doctor.

Triveen-CF NAC is a nutritional supplement. It works by providing the body with folate, vitamin B12, and a form of antioxidant, which helps to reduce or eliminate oxidative stress and lower homocysteine levels.

Do NOT use Triveen-CF NAC if: you are allergic to any ingredient in Triveen-CF NAC you are very ill

Contact your doctor or health care provider right away if any of these apply to you.

Before using Triveen-CF NAC:

Some medical conditions may interact with Triveen-CF NAC. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have anemia, liver problems, kidney stones, or a history of ulcers

Some MEDICINES MAY INTERACT with Triveen-CF NAC. Tell your health care provider if you are taking any other medicines, especially any of the following:

Antibiotics (eg, penicillin, cephalexin, ciprofloxacin), cholestyramine, colchicine, colestipol, metformin, nitrous oxide, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), para-aminosalicylic acid, potassium chloride, or sulfasalazine because they may decrease the effectiveness of Triveen-CF NAC Fluorouracil or nitrates (eg, nitroglycerin) because their side effects may be increased Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), primidone, pyrimethamine, or valproic acid because their effectiveness may be decreased by Triveen-CF NAC

This may not be a complete list of all interactions that may occur. Ask your health care provider if Triveen-CF NAC may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Triveen-CF NAC:

Use Triveen-CF NAC as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Triveen-CF NAC may be taken with or without food. If you miss a dose of Triveen-CF NAC, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Triveen-CF NAC.

Important safety information: Diabetes patients - Triveen-CF NAC may cause incorrect test results with some ketone tests. Check with your doctor before you adjust the dose of your diabetes medicine or change your diet. Triveen-CF NAC is not recommended for use in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Triveen-CF NAC, discuss with your doctor the benefits and risks of using Triveen-CF NAC during pregnancy. Triveen-CF NAC is excreted in breast milk. Do not breastfeed while you are taking Triveen-CF NAC. Possible side effects of Triveen-CF NAC:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; headache; itching; mild diarrhea; mild fever; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); lower back or side pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Triveen-CF NAC:

Store Triveen-CF NAC at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, light, and moisture. Keep Triveen-CF NAC out of the reach of children and away from pets.

General information: If you have any questions about Triveen-CF NAC, please talk with your doctor, pharmacist, or other health care provider. Triveen-CF NAC is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Triveen-CF NAC. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Triveen-CF NAC resources Triveen-CF NAC Use in Pregnancy & Breastfeeding Triveen-CF NAC Drug Interactions Triveen-CF NAC Support Group 4 Reviews for Triveen-CF NAC - Add your own review/rating Compare Triveen-CF NAC with other medications Dietary Supplementation Hyperhomocysteinemia
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Naturetin


Generic Name: Bendroflumethiazide (ben-droe-floo-meth-EYE-a-zide)
Brand Name: Naturetin
Naturetin is used for:

Treating excess fluid buildup in the body caused by certain conditions or medicines. It may also be used to treat high blood pressure or for other conditions as determined by your doctor.

Naturetin is a thiazide diuretic. It works by helping the kidneys eliminate fluid from the body. Exactly how Naturetin works to treat high blood pressure is unknown.

Do NOT use Naturetin if: you are allergic to any ingredient in Naturetin or to any other sulfonamide medicine (eg sulfamethoxazole, glyburide, acetazolamide) you are unable to urinate you are taking dofetilide or ketanserin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Naturetin:

Some medical conditions may interact with Naturetin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have gout, kidney or liver problems, lupus, diabetes, asthma, parathyroid problems, high blood cholesterol or lipid levels, or low blood pressure if you have low blood sodium, chloride, potassium, or magnesium levels; or high blood calcium levels if you have recently had nerve surgery

Some MEDICINES MAY INTERACT with Naturetin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, ibuprofen) because the effectiveness of Naturetin may be decreased Barbiturates (eg, phenobarbital), corticosteroids (eg, prednisone), corticotropin (ACTH), narcotic pain medicines (eg, codeine, morphine, fentanyl), or medicines for high blood pressure because side effects of Naturetin may be increased Diazoxide or nondepolarizing muscle relaxants (eg, tubocurarine) because side effects may be increased by Naturetin Lithium because the risk of toxicity may be increased by Naturetin Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased by Naturetin Diabetes medicines (eg, glipizide, metformin) or insulin because their effectiveness may be decreased by Naturetin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Naturetin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Naturetin:

Use Naturetin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Naturetin may be taken with or without food. When you first start taking Naturetin, it may cause an increase in urine or in frequency of urination. To prevent this from affecting sleep, try not to take any dose later than 6 pm. Continue to use Naturetin even if you feel well. Do not miss any doses. If you miss a dose of Naturetin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Naturetin.

Important safety information: Naturetin may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Naturetin. Using Naturetin alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks. Naturetin may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness. Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Naturetin. Naturetin may cause high blood sugar (eg, thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor). If these symptoms occur, tell your doctor immediately. Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor. Naturetin may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Naturetin. Use a sunscreen or protective clothing if you must be outside for a prolonged period. Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking your medication even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms. Naturetin may interfere with certain lab tests. Make sure your doctors and lab personnel know you are using Naturetin. LAB TESTS, including kidney function, blood pressure, and blood electrolyte levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments. Use Naturetin with caution in the ELDERLY because they may be more sensitive to its effects. PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Naturetin during pregnancy. Naturetin is excreted in breast milk. Do not breast-feed while taking Naturetin. Possible side effects of Naturetin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; dizziness; headache; lightheadedness, especially when sitting up or standing; numbness or tingling of skin.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloating; confusion; decrease in amount of urine; drowsiness; gout; inability to keep an erection; muscle pain or cramps; nausea; rapid or irregular heartbeat; red, swollen, blistered, or peeling skin; restlessness; seizures; severe stomach pain; shortness of breath; sweating; unusual thirst; unusual tiredness or weakness; unusually dry mouth; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

See also: Naturetin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/DNN/), or emergency room immediately. Symptoms may include dry mouth; excessive urination followed by a decrease in amount of urine; muscle cramps; severe lightheadedness, especially upon standing; weak or irregular heartbeat.

Proper storage of Naturetin:

Store Naturetin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Naturetin out of the reach of children and away from pets.

General information: If you have any questions about Naturetin, please talk with your doctor, pharmacist, or other health care provider. Naturetin is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Naturetin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Naturetin resources Naturetin Side Effects (in more detail) Naturetin Use in Pregnancy & Breastfeeding Naturetin Drug Interactions Naturetin Support Group 0 Reviews for Naturetin - Add your own review/rating Compare Naturetin with other medications Edema High Blood Pressure
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Edex


Generic Name: alprostadil (Intraurethral route, Intravenous route, Intracavernosal route)

al-PROS-ta-dil

Intravenous route(Solution)

Apnea is experienced by about 10% to 12% of neonates with congenital heart defects treated with alprostadil injection. Apnea is most often seen in neonates weighing less than 2 kg at birth and usually appears during the first hour of drug infusion. Therefore, respiratory status should be monitored throughout treatment, and alprostadil injection should be used only where ventilatory assistance is immediately available .

Commonly used brand name(s)

In the U.S.

Caverject Edex Muse Prostin VR Pediatric

In Canada

Muse Micro

Available Dosage Forms:

Powder for Solution Kit Suppository Solution

Therapeutic Class: Erectile Dysfunction Agent

Pharmacologic Class: Prostaglandin

Uses For Edex

Alprostadil belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. Alprostadil is used to produce erections in some men who need treatment for erectile dysfunction (sexual impotence). This medicine causes an erection because it increases the blood flow to the penis.

Alprostadil injection should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

Alprostadil is used alone or with medical tests to help diagnose erectile dysfunction that may be caused by nerve or blood vessel problems in the penis.

Alprostadil is available only with your doctor's prescription.

Before Using Edex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Heparin Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Abnormal penis, including curved penis and birth defects of the penis—Chance of problems occurring may be increased Bleeding problems—Chance of bleeding at the place of injection may be increased Infection of penis or Red or itchy (inflamed) penis—Conditions may worsen with the use of alprostadil suppositories. Also, local skin problems and minor bleeding from inserting the suppository may occur Conditions causing thickened blood or slower blood flow, including leukemia; multiple myeloma (tumors of the bone marrow); polycythemia, sickle cell disease, or thrombocythemia (blood problems) or Priapism (history of)—Patients with these conditions have an increased risk of priapism (erection lasting longer than 6 hours) while using alprostadil Proper Use of alprostadil

This section provides information on the proper use of a number of products that contain alprostadil. It may not be specific to Edex. Please read with care.

Special patient directions come with the suppositories and some of the injection medicines. Read the directions carefully before using the medicine.

For the injections—There are several alprostadil products that can be injected. Although the injection method is the same, the mixing procedures are different. Be sure you know which of these products you will be using and the proper way to mix the injection.

One product called Alprostadil for Injection (brand names Caverject and Edex) is available as a powder in an injection bottle (vial). Caverject must be mixed with a solution called Bacteriostatic Water for Injection USP. Edex must be mixed with a solution called Sodium Chloride Injection USP. The solution for mixing comes with your product and may be already loaded into a syringe or contained in another injection bottle (vial). Another product is called Alprostadil Injection (brand names Prostin VR Pediatric and Prostin VR). Although the medicine is already in solution, it is much too strong to be injected into the penis. The solution must be mixed (diluted) with another liquid that is sold as a separate prescription, called 0.9% Sodium Chloride Injection USP. In most cases, a pharmacist will make this solution for you, giving you the proper strength that you need. Check with your doctor or pharmacist to make sure the solution has been diluted before using it.

It is important to follow several steps to prepare your alprostadil injection correctly. Before drawing up the medicine into the syringe:

Wash your hands with soap and water. Set the bottles on a clean surface. Wipe the top of the injection bottles with an alcohol swab. Do not wipe the needle. Throw away the alcohol swab. You may need to attach the needle to the syringe. Do not take the cap off yet.

How to mix Caverject:

If the syringe already contains the Bacteriostatic Water for Injection USP, then you need only add the plunger to the syringe. To do this: Pick up the rod-like plunger and place it within the barrel of the syringe until it touches the rubber piece. Gently screw the plunger into the rubber piece until it seems secure. Do not use a lot of force. Hold the syringe by the barrel (not the plunger) and take the cap off the needle. You are now ready to mix the water and the powder. Skip to the directions under the title, “To mix the water and powder." If the syringe does not already contain the Bacteriostatic Water for Injection USP, you must withdraw 1 milliliter (mL) of it from the bottle provided. To do this: Pick up the syringe and take the cap off the needle. Pull the plunger back to the 1-mL mark on the syringe. This pulls air into the syringe. Insert the needle into rubber top of the bottle while it is upright and inject the 1 mL of air into the bottle. Turn the bottle upside down using one hand. Be sure the tip of the needle is covered by solution. With your other hand, pull the plunger back slowly to withdraw 1 mL of solution into the syringe. Remove the needle and skip to the directions under the title, "To mix the water and powder." To mix the water and powder: Insert the needle into the bottle of alprostadil and inject 1 milliliter of Bacteriostatic Water for Injection USP from your syringe into the bottle of alprostadil. Remove the needle from the bottle, holding the barrel of the syringe. Gently swirl the bottle to mix the powder into the solution, turning it upside down to wet all the powder in the bottle. Follow the directions below, “How to draw your dose into the syringe."

How to mix Edex:

The syringe already contains the Sodium Chloride Injection USP. You need only attach the needle to the syringe and add the plunger. To do this: Remove the needle from its package. Do not remove the needle cap. Gently screw the needle into place on the syringe tip. Pick up the rod-like plunger and place it within the barrel of the syringe until it touches the rubber piece. Gently screw the plunger into the rubber piece until it seems secure. Do not use a lot of force. Hold the syringe by the barrel (not the plunger) and take the cap off the needle. You are now ready to mix the Sodium Chloride Injection USP and the powder. Insert the needle into the bottle of alprostadil and inject 1.2 milliliters of the Sodium Chloride Injection USP from your syringe into the bottle of alprostadil. Remove the needle from the bottle, holding the barrel of the syringe. Gently swirl the bottle to mix the powder into the solution, turning it upside down to wet all the powder in the bottle. Follow the directions below, “How to draw your dose into the syringe."

How to mix Prostin VR or Prostin VR Pediatric:

You will need to get exact mixing instructions from your doctor or pharmacist if you are given two solutions to be mixed. Follow them carefully, asking the pharmacist or doctor any questions that you might have before injecting the medicine. After you or the pharmacist has mixed these solutions, follow the directions below, “How to draw your dose into the syringe."

How to draw your dose into the syringe (for all injection products):

Check the solution to make sure it is clear. Do not use the mixture if you can see anything solid in the solution or if the solution is cloudy or colored. After the alprostadil solution is mixed and the needle is inserted into the alprostadil bottle, turn the bottle with the syringe as a unit upside down in one hand. Be sure the tip of the needle is covered by the solution. With your other hand, pull the plunger back slowly to draw the correct dose of the medicine into the syringe. Hold the syringe with the measuring scale at eye level to see that the proper dose is withdrawn and to check for air bubbles. To remove air bubbles, tap gently on the measuring scale of the syringe to move any bubbles to the top of the syringe near the needle. If your dose measures too low in the syringe, withdraw more solution from the bottle. If there is too much medicine in the syringe, put some back into the bottle. Then check your dose again. Remove the needle from the bottle, holding the barrel of the syringe, not the plunger. Place the cover back on the needle. You are now ready to inject your dose. Follow the directions below, “How to give the alprostadil injection."

How to give the alprostadil injection:

Choose a spot on your penis as directed by your doctor where you will give the injection. Clean the injection site with alcohol. Sitting upright or slightly reclined, hold your penis against the side of your thigh so that it cannot move. Remove the cover from the needle and hold the needle at a 90-degree angle to the place of injection. Insert the needle until almost all of the metal part of the needle is inserted into the penis. Do not inject the medicine just under the surface of the skin, at the top or head of the penis, or at the base of the penis near the scrotum or testes. Avoid injecting the medicine into blood vessels that you can see. Press the plunger down slowly, taking 5 to 10 seconds to release the dose into the penis. The injection is usually not painful. If the injection is very painful or if you notice bruising or swelling at the place of injection, that means you are injecting the medicine under the skin. Stop, withdraw the needle, and reposition it properly before continuing with the injection. Remove the needle and recap it. After you have completed the injection, put pressure on the place of injection for about 5 minutes or until any bleeding stops. This will prevent bruising. Then massage your penis as instructed by your doctor. This helps the medicine spread to all parts of the penis, so that the medicine will work better.

Choose a different place of injection each time you use the medicine to prevent skin problems. This includes switching the place of injection from the right side of the penis for one injection to the left side for the next injection.

After a single-use injection is mixed, the medicine must be used immediately. Throw away any unused mixture in the syringe. It cannot be stored for a later injection.

Do not reuse your needles.

How to throw away the syringes and bottles safely:

Dispose of your materials properly. Caverject comes in a plastic case that can be permanently locked with the red locking device that is included with the packaging. When the case label is removed, you can see a hole in the center of the case. The red locking device can be inserted and, by firmly pressing it down with your thumb, you will permanently lock the case. The locked case is safe to be thrown away.

If you do not have the plastic case or are using Prostin VR or Prostin VR Pediatric injection, unscrew the needle from the barrel of the syringe. Then bend, break, or cut the needle into two pieces with wire cutters. The pieces can be placed in a heavy plastic container, such as a bleach container, and thrown away. Or you may give them to a health care professional to throw away. If you have any questions about disposing of the syringe and needles, ask your health care professional.

For suppositories—Before inserting the suppository, you should urinate. The small amount of urine normally left in your urethra will help dissolve the suppository after it is inserted.

How to insert suppositories:

Remove the delivery device containing the suppository from the foil. Remove the cap from the applicator stem. Stretch your penis upward to extend its length, pressing your penis top and bottom. Gently insert the delivery stem up to its collar into your urethra (located at the top of the penis). If you have pain or a pulling feeling in the penis, withdraw the device and start again. Press the button down slowly as far as it will go. This releases the suppository into the urethra. After holding the delivery device within your penis still for 5 seconds, carefully rock the penis and delivery device as a unit from side to side. This helps remove the suppository from the device. Remove the delivery device while your penis is upright. Look at the device to make sure that the suppository was completely released. Repeat the process if a part of the suppository remains in the device. After the suppository is completely released, roll your penis between your hands for 10 seconds. This helps to dissolve the suppository. If you feel any stinging, continue this motion to help stop it. Sitting, standing, or walking for 10 minutes while an erection is developing helps increase the blood flow to your penis to gain a proper erection.

How to throw away the suppository delivery device safely:

Replace the cap on the delivery device. After storing it in the foil, fold and throw away.

For injections or suppositories—This medicine usually begins to work in about 5 to 10 minutes. You should attempt intercourse within 10 to 30 minutes after using the medicine. An erection may continue after ejaculation.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For the treatment of erectile dysfunction: For injection dosage form: Adults—1.25 to 60 micrograms (mcg) as a single dose once a day. Your exact dose will be determined by your doctor. Inject this medicine very slowly into your penis as shown to you by your doctor ten to thirty minutes before intercourse. Allow five to ten seconds to completely inject the dose. Do not inject more than one dose within twenty-four hours. Also, do not use this medicine for more than two days in a row or more than three times a week. For suppository dosage form: Adults—125, 250, 500, or 1000 mcg as a single dose once a day. Your exact dose will be determined by your doctor. Insert this medicine into the urethra of your penis as shown to you by your doctor ten to thirty minutes before intercourse. Do not insert more than two doses within twenty-four hours. Storage

Store in the refrigerator. Do not freeze.

You may store the suppositories in the refrigerator, but do not freeze them.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Alprostadil for Injection while in the powder form can be stored at room temperature (between 15 and 25 °C or 59 and 77 °F) for 3 months. After it is mixed, the solution must be used immediately. Suppositories may be stored at room temperature

Precautions While Using Edex

Do not use alprostadil if you have a penile implant unless advised by doctor.

If using the alprostadil suppository, use a condom when having sexual intercourse with a pregnant female. Although harm to the fetus is unlikely, using a condom will protect the fetus from exposure to this medicine. If a woman can become pregnant, use of contraceptive methods is recommended because the effects of this medicine on early pregnancy are not known.

Use alprostadil exactly as directed by your doctor . Do not use more of it and do not use it more often than your doctor ordered. If too much is used, the erection lasts too long and does not reverse when it should. This condition is called priapism. If the erection is not reversed, the blood supply to the penis may be cut off and permanent damage may occur.

Contact your doctor immediately if the erection lasts longer than 4 hours or if it becomes painful. This may be a sign of priapism and must be treated right away to prevent permanent damage.

If you notice bleeding at the place where you injected the medicine, put pressure on the spot until the bleeding stops. If it doesn't stop within 10 minutes, check with your doctor.

Edex Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Curving of penis with pain during erection erection continuing for 4 to 6 hours erection continuing longer than 6 hours with severe and continuing pain of the penis swelling in or pain of the testes Symptoms of too much medicine being absorbed into the body Dizziness faintness pelvic pain flu-like symptoms

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Bleeding at place of injection, short-term mild bleeding or spotting from urethra (suppository only) pain at place of injection painful erection stinging of urethra (suppository only) Rare

Female partners may experience itching or stinging of vagina when you first begin using the alprostadil suppository. These side effects may not be caused from the medicine but may result if female partner has not had frequent or recent sexual intercourse.

Bruising or clotted blood in penis at place of injection, usually caused by an incorrect injection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Edex side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Edex resources Edex Side Effects (in more detail) Edex Use in Pregnancy & Breastfeeding Edex Drug Interactions Edex Support Group 9 Reviews for Edex - Add your own review/rating Edex MedFacts Consumer Leaflet (Wolters Kluwer) Edex injectable and transurethral Concise Consumer Information (Cerner Multum) Alprostadil MedFacts Consumer Leaflet (Wolters Kluwer) Alprostadil Prescribing Information (FDA) Alprostadil Monograph (AHFS DI) Caverject Prescribing Information (FDA) Muse Suppository MedFacts Consumer Leaflet (Wolters Kluwer) Muse Prescribing Information (FDA) Prostin VR Pediatric Prescribing Information (FDA) Compare Edex with other medications Erectile Dysfunction
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Muse


Generic Name: alprostadil (Intraurethral route, Intravenous route, Intracavernosal route)

al-PROS-ta-dil

Intravenous route(Solution)

Apnea is experienced by about 10% to 12% of neonates with congenital heart defects treated with alprostadil injection. Apnea is most often seen in neonates weighing less than 2 kg at birth and usually appears during the first hour of drug infusion. Therefore, respiratory status should be monitored throughout treatment, and alprostadil injection should be used only where ventilatory assistance is immediately available .

Commonly used brand name(s)

In the U.S.

Caverject Edex Muse Prostin VR Pediatric

In Canada

Muse Micro

Available Dosage Forms:

Powder for Solution Kit Suppository Solution

Therapeutic Class: Erectile Dysfunction Agent

Pharmacologic Class: Prostaglandin

Uses For Muse

Alprostadil belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. Alprostadil is used to produce erections in some men who need treatment for erectile dysfunction (sexual impotence). This medicine causes an erection because it increases the blood flow to the penis.

Alprostadil injection should not be used as a sexual aid by men who do not have erectile dysfunction. If the medicine is not used properly, permanent damage to the penis and loss of the ability to have erections could result.

Alprostadil is used alone or with medical tests to help diagnose erectile dysfunction that may be caused by nerve or blood vessel problems in the penis.

Alprostadil is available only with your doctor's prescription.

Before Using Muse

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Heparin Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Abnormal penis, including curved penis and birth defects of the penis—Chance of problems occurring may be increased Bleeding problems—Chance of bleeding at the place of injection may be increased Infection of penis or Red or itchy (inflamed) penis—Conditions may worsen with the use of alprostadil suppositories. Also, local skin problems and minor bleeding from inserting the suppository may occur Conditions causing thickened blood or slower blood flow, including leukemia; multiple myeloma (tumors of the bone marrow); polycythemia, sickle cell disease, or thrombocythemia (blood problems) or Priapism (history of)—Patients with these conditions have an increased risk of priapism (erection lasting longer than 6 hours) while using alprostadil Proper Use of alprostadil

This section provides information on the proper use of a number of products that contain alprostadil. It may not be specific to Muse. Please read with care.

Special patient directions come with the suppositories and some of the injection medicines. Read the directions carefully before using the medicine.

For the injections—There are several alprostadil products that can be injected. Although the injection method is the same, the mixing procedures are different. Be sure you know which of these products you will be using and the proper way to mix the injection.

One product called Alprostadil for Injection (brand names Caverject and Edex) is available as a powder in an injection bottle (vial). Caverject must be mixed with a solution called Bacteriostatic Water for Injection USP. Edex must be mixed with a solution called Sodium Chloride Injection USP. The solution for mixing comes with your product and may be already loaded into a syringe or contained in another injection bottle (vial). Another product is called Alprostadil Injection (brand names Prostin VR Pediatric and Prostin VR). Although the medicine is already in solution, it is much too strong to be injected into the penis. The solution must be mixed (diluted) with another liquid that is sold as a separate prescription, called 0.9% Sodium Chloride Injection USP. In most cases, a pharmacist will make this solution for you, giving you the proper strength that you need. Check with your doctor or pharmacist to make sure the solution has been diluted before using it.

It is important to follow several steps to prepare your alprostadil injection correctly. Before drawing up the medicine into the syringe:

Wash your hands with soap and water. Set the bottles on a clean surface. Wipe the top of the injection bottles with an alcohol swab. Do not wipe the needle. Throw away the alcohol swab. You may need to attach the needle to the syringe. Do not take the cap off yet.

How to mix Caverject:

If the syringe already contains the Bacteriostatic Water for Injection USP, then you need only add the plunger to the syringe. To do this: Pick up the rod-like plunger and place it within the barrel of the syringe until it touches the rubber piece. Gently screw the plunger into the rubber piece until it seems secure. Do not use a lot of force. Hold the syringe by the barrel (not the plunger) and take the cap off the needle. You are now ready to mix the water and the powder. Skip to the directions under the title, “To mix the water and powder." If the syringe does not already contain the Bacteriostatic Water for Injection USP, you must withdraw 1 milliliter (mL) of it from the bottle provided. To do this: Pick up the syringe and take the cap off the needle. Pull the plunger back to the 1-mL mark on the syringe. This pulls air into the syringe. Insert the needle into rubber top of the bottle while it is upright and inject the 1 mL of air into the bottle. Turn the bottle upside down using one hand. Be sure the tip of the needle is covered by solution. With your other hand, pull the plunger back slowly to withdraw 1 mL of solution into the syringe. Remove the needle and skip to the directions under the title, "To mix the water and powder." To mix the water and powder: Insert the needle into the bottle of alprostadil and inject 1 milliliter of Bacteriostatic Water for Injection USP from your syringe into the bottle of alprostadil. Remove the needle from the bottle, holding the barrel of the syringe. Gently swirl the bottle to mix the powder into the solution, turning it upside down to wet all the powder in the bottle. Follow the directions below, “How to draw your dose into the syringe."

How to mix Edex:

The syringe already contains the Sodium Chloride Injection USP. You need only attach the needle to the syringe and add the plunger. To do this: Remove the needle from its package. Do not remove the needle cap. Gently screw the needle into place on the syringe tip. Pick up the rod-like plunger and place it within the barrel of the syringe until it touches the rubber piece. Gently screw the plunger into the rubber piece until it seems secure. Do not use a lot of force. Hold the syringe by the barrel (not the plunger) and take the cap off the needle. You are now ready to mix the Sodium Chloride Injection USP and the powder. Insert the needle into the bottle of alprostadil and inject 1.2 milliliters of the Sodium Chloride Injection USP from your syringe into the bottle of alprostadil. Remove the needle from the bottle, holding the barrel of the syringe. Gently swirl the bottle to mix the powder into the solution, turning it upside down to wet all the powder in the bottle. Follow the directions below, “How to draw your dose into the syringe."

How to mix Prostin VR or Prostin VR Pediatric:

You will need to get exact mixing instructions from your doctor or pharmacist if you are given two solutions to be mixed. Follow them carefully, asking the pharmacist or doctor any questions that you might have before injecting the medicine. After you or the pharmacist has mixed these solutions, follow the directions below, “How to draw your dose into the syringe."

How to draw your dose into the syringe (for all injection products):

Check the solution to make sure it is clear. Do not use the mixture if you can see anything solid in the solution or if the solution is cloudy or colored. After the alprostadil solution is mixed and the needle is inserted into the alprostadil bottle, turn the bottle with the syringe as a unit upside down in one hand. Be sure the tip of the needle is covered by the solution. With your other hand, pull the plunger back slowly to draw the correct dose of the medicine into the syringe. Hold the syringe with the measuring scale at eye level to see that the proper dose is withdrawn and to check for air bubbles. To remove air bubbles, tap gently on the measuring scale of the syringe to move any bubbles to the top of the syringe near the needle. If your dose measures too low in the syringe, withdraw more solution from the bottle. If there is too much medicine in the syringe, put some back into the bottle. Then check your dose again. Remove the needle from the bottle, holding the barrel of the syringe, not the plunger. Place the cover back on the needle. You are now ready to inject your dose. Follow the directions below, “How to give the alprostadil injection."

How to give the alprostadil injection:

Choose a spot on your penis as directed by your doctor where you will give the injection. Clean the injection site with alcohol. Sitting upright or slightly reclined, hold your penis against the side of your thigh so that it cannot move. Remove the cover from the needle and hold the needle at a 90-degree angle to the place of injection. Insert the needle until almost all of the metal part of the needle is inserted into the penis. Do not inject the medicine just under the surface of the skin, at the top or head of the penis, or at the base of the penis near the scrotum or testes. Avoid injecting the medicine into blood vessels that you can see. Press the plunger down slowly, taking 5 to 10 seconds to release the dose into the penis. The injection is usually not painful. If the injection is very painful or if you notice bruising or swelling at the place of injection, that means you are injecting the medicine under the skin. Stop, withdraw the needle, and reposition it properly before continuing with the injection. Remove the needle and recap it. After you have completed the injection, put pressure on the place of injection for about 5 minutes or until any bleeding stops. This will prevent bruising. Then massage your penis as instructed by your doctor. This helps the medicine spread to all parts of the penis, so that the medicine will work better.

Choose a different place of injection each time you use the medicine to prevent skin problems. This includes switching the place of injection from the right side of the penis for one injection to the left side for the next injection.

After a single-use injection is mixed, the medicine must be used immediately. Throw away any unused mixture in the syringe. It cannot be stored for a later injection.

Do not reuse your needles.

How to throw away the syringes and bottles safely:

Dispose of your materials properly. Caverject comes in a plastic case that can be permanently locked with the red locking device that is included with the packaging. When the case label is removed, you can see a hole in the center of the case. The red locking device can be inserted and, by firmly pressing it down with your thumb, you will permanently lock the case. The locked case is safe to be thrown away.

If you do not have the plastic case or are using Prostin VR or Prostin VR Pediatric injection, unscrew the needle from the barrel of the syringe. Then bend, break, or cut the needle into two pieces with wire cutters. The pieces can be placed in a heavy plastic container, such as a bleach container, and thrown away. Or you may give them to a health care professional to throw away. If you have any questions about disposing of the syringe and needles, ask your health care professional.

For suppositories—Before inserting the suppository, you should urinate. The small amount of urine normally left in your urethra will help dissolve the suppository after it is inserted.

How to insert suppositories:

Remove the delivery device containing the suppository from the foil. Remove the cap from the applicator stem. Stretch your penis upward to extend its length, pressing your penis top and bottom. Gently insert the delivery stem up to its collar into your urethra (located at the top of the penis). If you have pain or a pulling feeling in the penis, withdraw the device and start again. Press the button down slowly as far as it will go. This releases the suppository into the urethra. After holding the delivery device within your penis still for 5 seconds, carefully rock the penis and delivery device as a unit from side to side. This helps remove the suppository from the device. Remove the delivery device while your penis is upright. Look at the device to make sure that the suppository was completely released. Repeat the process if a part of the suppository remains in the device. After the suppository is completely released, roll your penis between your hands for 10 seconds. This helps to dissolve the suppository. If you feel any stinging, continue this motion to help stop it. Sitting, standing, or walking for 10 minutes while an erection is developing helps increase the blood flow to your penis to gain a proper erection.

How to throw away the suppository delivery device safely:

Replace the cap on the delivery device. After storing it in the foil, fold and throw away.

For injections or suppositories—This medicine usually begins to work in about 5 to 10 minutes. You should attempt intercourse within 10 to 30 minutes after using the medicine. An erection may continue after ejaculation.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For the treatment of erectile dysfunction: For injection dosage form: Adults—1.25 to 60 micrograms (mcg) as a single dose once a day. Your exact dose will be determined by your doctor. Inject this medicine very slowly into your penis as shown to you by your doctor ten to thirty minutes before intercourse. Allow five to ten seconds to completely inject the dose. Do not inject more than one dose within twenty-four hours. Also, do not use this medicine for more than two days in a row or more than three times a week. For suppository dosage form: Adults—125, 250, 500, or 1000 mcg as a single dose once a day. Your exact dose will be determined by your doctor. Insert this medicine into the urethra of your penis as shown to you by your doctor ten to thirty minutes before intercourse. Do not insert more than two doses within twenty-four hours. Storage

Store in the refrigerator. Do not freeze.

You may store the suppositories in the refrigerator, but do not freeze them.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Alprostadil for Injection while in the powder form can be stored at room temperature (between 15 and 25 °C or 59 and 77 °F) for 3 months. After it is mixed, the solution must be used immediately. Suppositories may be stored at room temperature

Precautions While Using Muse

Do not use alprostadil if you have a penile implant unless advised by doctor.

If using the alprostadil suppository, use a condom when having sexual intercourse with a pregnant female. Although harm to the fetus is unlikely, using a condom will protect the fetus from exposure to this medicine. If a woman can become pregnant, use of contraceptive methods is recommended because the effects of this medicine on early pregnancy are not known.

Use alprostadil exactly as directed by your doctor . Do not use more of it and do not use it more often than your doctor ordered. If too much is used, the erection lasts too long and does not reverse when it should. This condition is called priapism. If the erection is not reversed, the blood supply to the penis may be cut off and permanent damage may occur.

Contact your doctor immediately if the erection lasts longer than 4 hours or if it becomes painful. This may be a sign of priapism and must be treated right away to prevent permanent damage.

If you notice bleeding at the place where you injected the medicine, put pressure on the spot until the bleeding stops. If it doesn't stop within 10 minutes, check with your doctor.

Muse Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare Curving of penis with pain during erection erection continuing for 4 to 6 hours erection continuing longer than 6 hours with severe and continuing pain of the penis swelling in or pain of the testes Symptoms of too much medicine being absorbed into the body Dizziness faintness pelvic pain flu-like symptoms

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common Bleeding at place of injection, short-term mild bleeding or spotting from urethra (suppository only) pain at place of injection painful erection stinging of urethra (suppository only) Rare

Female partners may experience itching or stinging of vagina when you first begin using the alprostadil suppository. These side effects may not be caused from the medicine but may result if female partner has not had frequent or recent sexual intercourse.

Bruising or clotted blood in penis at place of injection, usually caused by an incorrect injection

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Muse side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Muse resources Muse Side Effects (in more detail) Muse Use in Pregnancy & Breastfeeding Muse Drug Interactions Muse Support Group 4 Reviews for Muse - Add your own review/rating Muse Prescribing Information (FDA) Muse Suppository MedFacts Consumer Leaflet (Wolters Kluwer) Muse injectable and transurethral Concise Consumer Information (Cerner Multum) Alprostadil Monograph (AHFS DI) Alprostadil Prescribing Information (FDA) Alprostadil MedFacts Consumer Leaflet (Wolters Kluwer) Caverject Prescribing Information (FDA) Edex MedFacts Consumer Leaflet (Wolters Kluwer) Prostin VR Pediatric Prescribing Information (FDA) Compare Muse with other medications Erectile Dysfunction
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chondroitin, glucosamine, and methylsulfonylmethane


Generic Name: chondroitin, glucosamine, and methylsulfonylmethane (kon DROI tin, gloo KOSE a meen, and METH il sul FON il METH ane)
Brand names: Glucosamine & Chondroitin with MSM, Glucosamine Chondroitin MSM Complex, Osteo Bi-Flex Advanced, Osteo Bi-Flex Plus MSM, Glucosamine & Chondroitin with MSM

What is chondroitin, glucosamine, and methylsulfonylmethane?

Chondroitin is a naturally occurring substance formed of sugar chains. Chondroitin is believed to help the body maintain fluid and flexibility in the joints.

Glucosamine is a naturally occurring substance that is believed to help develop and renew cartilage (the hard connective tissue mainly located on bones near joints in the body), and keep it lubricated for better joint movement and flexibility.

Methylsulfonylmethane is a naturally occurring form of sulfur that helps support muscles and tendons in the body.

The combination of chondroitin, glucosamine, and methylsulfonylmethane is used to aid in maintaining healthy joints. It is also used as a nutritional supplement in people with osteoarthritis or other inflammatory joint disorders.

Not all uses for chondroitin, glucosamine, and methylsulfonylmethane have been approved by the FDA. Chondroitin, glucosamine, and methylsulfonylmethane should not be used in place of medication prescribed for you by your doctor.

Chondroitin, glucosamine, and methylsulfonylmethane is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Chondroitin, glucosamine, and methylsulfonylmethane may also be used for purposes not listed in this product guide.

What is the most important information I should know about chondroitin, glucosamine, and methylsulfonylmethane? Not all uses for this product have been approved by the FDA. Chondroitin, glucosamine, and methylsulfonylmethane should not be used in place of medication prescribed for you by your doctor.

Chondroitin, glucosamine, and methylsulfonylmethane is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Before using this product, talk to your doctor, pharmacist, herbalist, or other healthcare provider. You may not be able to use chondroitin, glucosamine, and methylsulfonylmethane if you have diabetes, a bleeding or blood clotting disorder such as hemophilia, if you have allergies to certain drugs, if you are overweight, or if you are on a low-salt diet.

Do not take chondroitin, glucosamine, and methylsulfonylmethane without the medical advice if you are using insulin, or a blood thinner such as warfarin (Coumadin, Jantoven). Avoid taking chitosan (usually marketed as a weight-loss product) while you are taking chondroitin, glucosamine, and methylsulfonylmethane. Chitosan can make it harder for your body to absorb chondroitin. What should I discuss with my healthcare provider before taking chondroitin, glucosamine, and methylsulfonylmethane? You should not use this product if you are allergic to it.

Ask a doctor, pharmacist, herbalist, or other healthcare provider if it is safe for you to use this product if you have:

diabetes;

a bleeding or blood clotting disorder such as hemophilia;

if you have allergies to certain drugs;

if you are overweight; or

if you are on a low-salt diet.

It is not known whether chondroitin, glucosamine, and methylsulfonylmethane will harm an unborn baby. Tell your healthcare provider if you are pregnant or plan to become pregnant while using this product. It is not known whether chondroitin, glucosamine, and methylsulfonylmethane passes into breast milk or if it could harm a nursing baby. Do not use this product without telling your healthcare provider if you are breast-feeding a baby. How should I take chondroitin, glucosamine, and methylsulfonylmethane?

When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use chondroitin, glucosamine, and methylsulfonylmethane, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

It may take up several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after a few weeks of treatment.

Glucosamine may increase the glucose (sugar) levels in your blood. If you have diabetes, you may need to check your blood sugar more often while taking this medication. You may also need to adjust your insulin dosage. Do not change your dose or medication schedule without advice from your doctor.

Chondroitin, glucosamine, and methylsulfonylmethane may be only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light. What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking chondroitin, glucosamine, and methylsulfonylmethane? Avoid taking chitosan (usually marketed as a weight-loss product) while you are taking chondroitin, glucosamine, and methylsulfonylmethane. Chitosan can make it harder for your body to absorb chondroitin. Chondroitin, glucosamine, and methylsulfonylmethane side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

mild nausea, upset stomach;

heartburn; or

diarrhea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect chondroitin, glucosamine, and methylsulfonylmethane?

Tell your doctor about all other medicines you use, especially:

insulin; or

a blood thinner such as warfarin (Coumadin, Jantoven).

This list is not complete and other drugs may interact with chondroitin, glucosamine, and methylsulfonylmethane. Tell your healthcare provider about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More chondroitin, glucosamine, and methylsulfonylmethane resources Chondroitin, glucosamine, and methylsulfonylmethane Drug Interactions Chondroitin, glucosamine, and methylsulfonylmethane Support Group 1 Review for Chondroitin, glucosamine, and methylsulfonylmethane - Add your own review/rating Compare chondroitin, glucosamine, and methylsulfonylmethane with other medications Dietary Supplementation Osteoarthritis Where can I get more information? Consult with a licensed healthcare professional before using any herbal/health supplement. Whether you are treated by a medical doctor or a practitioner trained in the use of natural medicines/supplements, make sure all your healthcare providers know about all of your medical conditions and treatments.
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Hytrin


Pronunciation: ter-AZ-oh-sin
Generic Name: Terazosin
Brand Name: Hytrin
Hytrin is used for:

Treating high blood pressure and treating signs and symptoms of benign prostatic hyperplasia (BPH).

Hytrin is an alpha-blocker. It works by relaxing muscles in the blood vessels, resulting in lowering of blood pressure. In BPH, alpha-blockers work by relaxing muscles around the urethra (tube that drains urine from the bladder), which improves urinary symptoms.

Do NOT use Hytrin if: you are allergic to any ingredient in Hytrin or to similar medicines (eg, prazosin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hytrin:

Some medical conditions may interact with Hytrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have prostate cancer, angina pectoris, heart disease, or kidney or liver problems if you will be having eye surgery

Some MEDICINES MAY INTERACT with Hytrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil) or verapamil because severe dizziness, lightheadedness, or fainting may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hytrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hytrin:

Use Hytrin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Hytrin by mouth with or without food. Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. If you miss a dose of Hytrin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Hytrin.

Important safety information: Hytrin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hytrin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hytrin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness. Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment. Hytrin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms. Do NOT take more than the recommended dose without checking with your doctor. Hytrin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens. Tell your doctor or dentist that you take Hytrin before you receive any medical or dental care, emergency care, or surgery (including eye surgery). Lab tests, including blood pressure, may be performed while you use Hytrin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Hytrin should not be used in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hytrin while you are pregnant. It is not known if Hytrin is found in breast milk. If you are or will be breast-feeding while you use Hytrin, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Hytrin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat;painful, prolonged erection; severe or prolonged dizziness or headache; shortness of breath; swelling of the ankles, feet, or hands.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Hytrin side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; weakness.

Proper storage of Hytrin:

Store Hytrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hytrin out of the reach of children and away from pets.

General information: If you have any questions about Hytrin, please talk with your doctor, pharmacist, or other health care provider. Hytrin is to be used only by the patient for whom it is prescribed. Do not share it with other people. Do not use it for other health conditions. If your symptoms do not improve or if they become worse, check with your doctor. If using Hytrin for an extended period of time, obtain refills before your supply runs out. Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Hytrin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Hytrin resources Hytrin Side Effects (in more detail) Hytrin Use in Pregnancy & Breastfeeding Drug Images Hytrin Drug Interactions Hytrin Support Group 11 Reviews for Hytrin - Add your own review/rating Hytrin Prescribing Information (FDA) Hytrin Consumer Overview Hytrin Monograph (AHFS DI) Hytrin Advanced Consumer (Micromedex) - Includes Dosage Information Terazosin Prescribing Information (FDA) Terazosin Professional Patient Advice (Wolters Kluwer) Compare Hytrin with other medications Benign Prostatic Hyperplasia High Blood Pressure Hyperhidrosis
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