what is equivalent to pernox facial scrub
 

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Ionax Scrub


Ionax Scrub may be available in the countries listed below.

Ingredient matches for Ionax Scrub Benzalkonium Chloride

Benzalkonium is reported as an ingredient of Ionax Scrub in the following countries:

Peru

International Drug Name Search


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VIDENE SURGICAL SCRUB (Ecolab)


1. Name Of The Medicinal Product

VIDENE SURGICAL SCRUB

2. Qualitative And Quantitative Composition

Povidone-iodine 7.5% w/w

3. Pharmaceutical Form

Topical solution.

4. Clinical Particulars 4.1 Therapeutic Indications

Videne Surgical Scrub is a broad-spectrum antiseptic for topical use. It is indicated for pre-operative hand disinfection by the surgical team, or for disinfecting the site of incision prior to elective surgery.

4.2 Posology And Method Of Administration

Pre-operative surgical scrub - after first wetting the hands and arms with water, approximately 3.5 ml of Videne Surgical Scrub is applied and rubbed thoroughly on to these areas. A brush may be used to scrub the nails. A little water is added to develop a lather and finally this is rinsed off with running water.

Pre-operative skin preparation - the site of incision should be washed with Videne Surgical Scrub two or three times a day for at least two days prior to the operation. Immediately before surgery the skin should be moistened with water, Videne Surgical Scrub applied and rubbed thoroughly into the area for several minutes. A sterile gauze swab is used to develop a lather which is finally rinsed off with water.

Only water should be used to dilute Videne Surgical Scrub.

There are no special dosage recommendations for children or elderly patients.

4.3 Contraindications

Videne Surgical Scrub must never be administered orally.

4.4 Special Warnings And Precautions For Use

Care should be taken when Videne Surgical Scrub is used on known iodine-sensitive subjects, although such people do not normally react to povidone-iodine.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None stated.

4.6 Pregnancy And Lactation

Videne Surgical Scrub is not recommended for use during pregnancy because of the possibility of absorption through broken skin and subsequent interference with tests of neonatal thyroid function.

4.7 Effects On Ability To Drive And Use Machines

None stated.

4.8 Undesirable Effects

In very rare instances Videne Surgical Scrub may produce skin reactions in iodine-sensitive subjects. These reactions subside on cessation of treatment.

4.9 Overdose

In cases where Videne Surgical Scrub has been taken orally, gastric lavage with dilute starch mucilage or a 1% solution of sodium thiosulphate must be administered. The electrolyte balance must be corrected and lost fluids replaced.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Povidone-iodine has antiseptic activity and is used mainly for the treatment of contaminated wounds and pre-operative preparation of skin and mucous membranes. It is considered to be less irritant than iodine.

5.2 Pharmacokinetic Properties

Povidone-iodine is slightly absorbed when applied to the skin. Iodides are excreted mainly in the urine, with smaller amounts appearing in the faeces, saliva and sweat.

5.3 Preclinical Safety Data

Povidone-iodine had a low acute toxicity in both dogs and cats following either oral or intraperitoneal administration. Absorption of iodine through intact skin is low following the application of solutions of povidone-iodine although systemic absorption of iodine is greatly increased if the solutions are applied to broken skin, mucous membranes or are introduced into cavities of the body. At subcutaneous dose levels of up to 75mg/Kg/day, povidone-iodine was non-teratogenic in rabbits following administration to pregnant animals during the period of organogenesis.

Some early in vitro studies indicated a possible mutagenic action for povidone-iodine. However, a number of later studies, using in vitro and in vivo test systems, do not indicate a significant level of mutagenic/genotoxic activity for povidone-iodine. Although conflicting data have been published, there is no convincing evidence to suggest that povidone-iodine adversely affects wound healing. Concentration of 0.05 and 0.5% povidone-iodine did not cause significant ocular damage when administered into the vitreous cavities of rabbits' eyes. There is some evidence to suggest that povidone-iodine-containing solutions applied to the round window of the chinchilla ear could result in high frequency hearing loss.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Alkyl Phenol Ether Sulphate (Ammonium Salt)

Polyethylene glycol 400

Cocoamide DEA

Glycerol

PVP K90

Citric acid

Di-sodium phosphate, anhydrous

Purified Water

6.2 Incompatibilities

None stated.

6.3 Shelf Life

24 months.

6.4 Special Precautions For Storage

Store below 30°C in a dry place, protected from light.

6.5 Nature And Contents Of Container

Videne Surgical Scrub is packaged in a 500 ml HDPE bottle sealed with a plastic screw cap.

6.6 Special Precautions For Disposal And Other Handling

None stated.

7. Marketing Authorisation Holder

Ecolab Ltd, Lotherton Way, Garforth, Leeds, LS25 2JY.

8. Marketing Authorisation Number(S)

PL 04509/0042

9. Date Of First Authorisation/Renewal Of The Authorisation

1 March 2003

10. Date Of Revision Of The Text

August 2006


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Mucositis Medications


Definition of Mucositis: Inflammation of a mucous membrane. Oral mucositis is a common complication of chemotherapy and radiation therapy.

Drugs associated with Mucositis

The following drugs and medications are in some way related to, or used in the treatment of Mucositis. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.


Drug List: Betasept-Liquid Biopatch Calgon-Vesta Caphosol-Solution Chlorostat Chlorostat-4 Denti-Care-Denti-Rinse Gelclair-Gel Hibiclens-Liquid Hibistat Kepivance Neutrasal-Powder Peridex-Solution Periochip Periogard-Solution Perisol-Oral-Rinse Salivart-Spray Scrub-Care Spectrum-4
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Isopropyl Alcohol



MWI 99% Isopropyl Alcohol quart MWI 99% Isopropyl Alcohol quart

CONTAINS:

Active Ingredients:

   Isopropyl Alcohol .........................99%

Inert Ingredients:

   Water ...............................................1%

INDICATIONS: Widely used by veterinarians and artificial inseminators as a bactericide and antiseptic.
May also be used for temporary relief of minor muscular aches or pains caused by overexerction or fatigue. For use in manufacturing, processing or repacking. 

DIRECTIONS FOR USE: Dilute with water as desired. Scrub hands and arms with soap and water. Rinse with water and then scrub with alcohol. As a rub-down, apply full-strength directly to the affected area. Wet thoroughly and massage briskly to stimulate circulation.

MWI 99% Isopropyl Alcohol quart

WARNING: Flammable Liquid

For External Use Only

STORAGE: Store at controlled room temperature between 10 and 30 C(50 - 85F). Keep away from heat and open flame. Keep container closed when not in use.

MADE IN USA         TAKE TIME          OBSERVE LABEL DIRECTIONS

Distributed by:
MWI
Meridian, ID 83680
(888) 694-8381
www.vetone.net

MWI 99% Isopropyl Alcohol quart jug213332 innercase213332 outercase213332


Isopropyl Alcohol 
Isopropyl Alcohol  liquid Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 13985-330 Route of Administration TOPICAL DEA Schedule      Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Isopropyl Alcohol (Isopropyl Alcohol) Isopropyl Alcohol 99 L  in 100 L Inactive Ingredients Ingredient Name Strength WATER 1 L  in 100 L Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains          Packaging # NDC Package Description Multilevel Packaging 1 13985-330-91 4 BOX In 1 CASE contains a BOX (13985-330-90) 1 13985-330-90 4 JUG In 1 BOX This package is contained within the CASE (13985-330-91) and contains a JUG (13985-330-89) 1 13985-330-89 0.946 L In 1 JUG This package is contained within a BOX (13985-330-90) and a CASE (13985-330-91)
Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date unapproved drug other 05/01/2010
Labeler - MWI/Vet One (019926120) Revised: 05/2010MWI/Vet One

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Mouth and throat products


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Topical mouth and throat products include agents such as antifungals, antiseptics, cough suppressants and saliva substitutes. They are used to treat conditions of the mouth and throat such as oral thrush, dry mouth, sore throat and tickly cough.

See also

Medical conditions associated with mouth and throat products:

Aphthous Stomatitis, Recurrent Aphthous Ulcer Cold Sores Cough Gastrointestinal Candidiasis Gingivitis Herpes Simplex Mucositis Nasal Congestion Oral and Dental Conditions Oral Thrush Pain Periodontitis Tonsillitis/Pharyngitis Xerostomia Drug List: Cepacol-Dual-Relief-Spray Neutrasal-Powder Mycelex-Troche Aphthasol Atridox Betasept-Liquid Bio-Statin-Powder Biopatch Calgon-Vesta Caphosol-Solution Cepacol-Sore-Throat-Lozenges Cetacaine-Liquid Chloraseptic-Lozenges Chlorostat Chlorostat-4 Denti-Care-Denti-Rinse Dyna-Hex Exactacain-Topical-Anesthetic-Spray First-Mouthwash-Blm Hibiclens-Liquid Hibistat Mycostatin Mycostatin-Pastilles Nilstat Peridex-Solution Periochip Periogard-Solution Perisol-Oral-Rinse Salivart-Spray Scrub-Care Spectrum-4 Vicks-Formula-44-Sore-Throat-Spray
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Betadine Surgical Scrub (Molnlycke Health Care )


1. Name Of The Medicinal Product

Betadine Surgical Scrub.

2. Qualitative And Quantitative Composition

Povidone Iodine 7.5% w/v.

3. Pharmaceutical Form

Surgical scrub.

4. Clinical Particulars 4.1 Therapeutic Indications

For use as an antiseptic cleanser for pre-operative scrubbing and washing by surgeons and theatre staff, and pre-operative preparation of patients' skin.

4.2 Posology And Method Of Administration

For topical administration. Adults, the elderly and children: Apply full strength as a pre-operative antiseptic skin cleanser. Povidone iodine is not recommended for regular use in neonates and is contraindicated in very low birth weight infants (below 1500 grams).

4.3 Contraindications

Known or suspected iodine hypersensitivity. Regular use is contraindicated in patients and users with thyroid disorders (in particular nodular colloid goitre, endemic goitre and Hashimoto's thyroiditis).

4.4 Special Warnings And Precautions For Use

Special caution is needed when regular applications to broken skin are made to patients with pre-existing renal insufficiency. Regular use should be avoided in patients on concurrent lithium therapy.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

Absorption of iodine from povidone iodine through either intact or damaged skin may interfere with thyroid function tests. Contamination with povidone iodine of several types of tests for the detection of occult blood in faeces or blood in urine may produce false-positive results.

4.6 Pregnancy And Lactation

Regular use of povidone iodine should be avoided in pregnant or lactating women as absorbed iodine can cross the placental barrier and can be secreted into breast milk. Although no adverse effects have been reported from limited use, caution should be recommended and therapeutic benefit must be balanced against possible effects of the absorption on foetal thyroid function and development.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Povidone iodine may produce local skin reactions although it is considered to be less irritant than iodine. The application of povidone iodine to large wounds or severe burns may produce systemic adverse effects such as metabolic acidosis, hypernatraemia and impairment of renal function.

4.9 Overdose

Excess iodine can produce goitre and hypothyroidism or hyperthyroidism. Systemic absorption of iodine after repeated application of povidone iodine to large areas of wounds or burns may lead to a number of adverse effects: metallic taste in mouth, irritation and swelling of the eyes, pulmonary oedema, skin reactions, gastrointestinal upset and diarrhoea, metabolic acidosis, hypernatraemia and impairment of renal function. In the case of accidental ingestion of large quantities of Betadine, symptomatic and supportive treatment should be provided with special attention to electrolyte balance and renal and thyroid function.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

The active ingredient, povidone iodine, slowly liberates iodine when in contact with skin and mucous membranes. The activity of 'iodine' as a microbicide is then governed by a series of dissociations: I2? I+ + I- ; I2 + H2O ? H2O I+ + I- ; I2 + I- ? I3-. The microbicidal species H2O I+ preferentially displaces oxygen as the end electron acceptor in the microorganism's respiratory cycle. H2O I+ similarly interacts within the electron transport chain and reacts with the amino acids of the microbial cell membrane.

5.2 Pharmacokinetic Properties

Betadine Surgical Scrub is intended for topical application and therefore a consideration of the absorption, distribution, metabolism and elimination of povidone iodine is largely without relevance.

5.3 Preclinical Safety Data

None stated.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Sulphated nonylphenoxypoly(oxyethylene) ethanol ammonium salt; lauric diethanolamide;

ethoxylated lanolin 50%; Natrosol HXR; sodium hydroxide; purified water.

6.2 Incompatibilities

None stated.

6.3 Shelf Life

36 months unopened.

6.4 Special Precautions For Storage

Store below 25oC and protect from light.

6.5 Nature And Contents Of Container

High density polyethylene containers fitted with steran lined white polypropylene caps containing 500ml of product.

6.6 Special Precautions For Disposal And Other Handling

None stated.

7. Marketing Authorisation Holder

Medlock Medical Limited, Tubiton House, Medlock Street, Oldham, OL1 3HS.

8. Marketing Authorisation Number(S)

PL 21248/0009.

9. Date Of First Authorisation/Renewal Of The Authorisation

6th April 2005.

10. Date Of Revision Of The Text

April 2006.


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Acne Medications


Definition of Acne: An inflammatory skin condition characterized by superficial skin eruptions around hair follicles. More...

Drugs associated with Acne

The following drugs and medications are in some way related to, or used in the treatment of Acne. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

See sub-topics

Topics under Acne Rosacea (77 drugs) Learn more about Acne

Medical Encyclopedia:

Acne Blackheads Comedones Teenagers and acne medicine Whitehead

Harvard Health Guide:

Symptoms and treatment for Acne
Drug List: A-T-S Acanya Accutane Acetoxyl-10-Topical Acne-Treatment-Cream Acne-10-Gel-Topical Acne-Clear Acnex-Topical Acnomel-Skin-Tone-Topical Acnomel-Acne-Mask-Topical Acnomel-Bp-5-Topical Acnotex Aczone Adoxa Adoxa-Ck-Kit Adoxa-Tt-Kit Akne-Mycin-Ointment Akurza-Topical Ala-Tet Aldactone Aliclen-Topical Alquam-X-Acne-Therapy-Gel-Topical Altabax Altinac Amnesteem Atralin Avar-Cream Avar-Cleanser Avar-Gel Avar-Green Avar-Ls-Cleanser Avar-E Avar-E-Emollient Avar-E-Green Avar-E-Ls Avidoxy Avita-Cream Azelex-Cream Bactrim Bactrim-Ds Bencort-Lotion Benprox Benzac-Topical Benzac-Ac-Wash Benzac-W Benzaclin Benzagel-5 5-Benzagel-Acne-Wash-Topical Benzamycin-Gel Benzamycin-Pak-Gel Benzashave-10 Benzefoam-Foam Benzefoam-Ultra-Topical Benziq Benziq-Ls Benziq-Wash Beyaz Binora-Topical Bio-Cef Bioelements-Active-Astringent Bp-10-Wash Bp-Wash Bpo-3-Foaming-Cloths Bpo-6-Foaming-Cloths Bpo-9-Foaming-Cloths Bpo-Foaming-Cloths Bpo-4-Gel-Topical Bps-Gel Brevicon Brevoxyl-Gel Brevoxyl-Acne-Wash-Kit Brevoxyl-Creamy-Wash-Complete-Pack-Wash-And-Cleansing-Bar Brevoxyl-4-Wash Brevoxyl-8-Wash Breze Briellyn Cerisa-Wash Claravis Clarifoam-Ef-Foam Cleanse-Treat Clear-Away-Wart-Removal-System-Topical Clearplex Clearskin-Cream Clenia-Emollient-Cream Clenia-Foaming-Wash Cleocin-T-Gel Clinac-Bpo Clinda-Derm-Topical Clindacin-P Clindagel Clindareach-Pledget Clindets-Swab Co-Trimoxazole Compound-W Cotrim Cyclafem-1-35 Cyclafem-7-7-7 Del-Aqua-Topical Delos-Liquid Dermalzone Dermarest-Psoriasis-Skin-Treatment Desquam-E Desquam-X-10 Desquam-X-5 Desquam-X-Wash Dhs-Sal-Topical Differin Doryx-Delayed-Release-Capsules Doxy-100 Doxy-200 Dr-Scholl-S-Callus-Removers Dr-Scholl-S-Clear-Away-Wart-Remover Dr-Scholl-S-Corn-Removers Dr-Scholl-S-Corn-Callous-Remover-Solution Dr-Scholl-S-Zino-Soft-Corn-Remover-Pads Duac-Cs-Kit-Gel Dulcolax-Milk-Of-Magnesia-Suspension Duofilm-Solution Duoplant-Gel Durasal-Topical Dynacin Emcin-Clear-Pad Emgel-Gel Epiduo Ery-Pads-Pad Erycette Eryderm-Solution Erygel Erymax Erythra-Derm Estrostep-Fe Ethexderm Ethexderm-Bpw-Wash Evoclin Ex-Lax-Milk-Of-Magnesia Femcon-Fe-Chewable-Tablets Femhrt Finacea Finevin Fostex-Cream Fostex-Bar-10 Fostex-Bpo-Bar Fostex-Gel-10 Fostex-Medicated-Soap Fostex-Cream-Topical Fostex-Wash-10 Fostril Freezone-One-Step-Callus-Remover-Pad-Topical Freezone-Liquid Freezone-Corn-Remover Genora-1-35 Gianvi Gildess-Fe-1-5-0-03 Gildess-Fe-1-0-2 Gordofilm-Topical Hydrisalic-Gel Inova-Pads Inova-4-1-Acne-Control-Therapy-Pads Inova-8-2 Ionil-Plus-Shampoo Jenest Jevantique Junel-1-5-30 Junel-1-20 Junel-Fe-1-5-30 Junel-Fe-1-20 Keflex Keralyt-Scalp-Shampoo Keralyt-Shampoo Keralyt-Gel Lavoclen-4 Lavoclen-4-Creamy-Wash Lavoclen-8 Lavoclen-8-Creamy-Wash Leena Liquimat-Light Liquimat-Medium Loestrin-1-20 Loestrin-21-1-5-30 Loestrin-21-1-20 Loestrin_24_Fe Loestrin-Fe-1-5-30 Loestrin-Fe-1-20 Loroxide Loryna Mediplast Meted-Shampoo Microgestin-1-5-30 Microgestin-1-20 Microgestin-Fe-1-5-30 Microgestin-Fe-1-20 Milk-Of-Magnesia Minocin Modicon Monodox Mosco-Corn-Callus-Remover-Topical Myrac Necon-0-5-35 Necon-1-35 Necon-10-11 Necon-7-7-7 Nelova-0-5-35 Neobenz-Micro Neobenz-Micro-Sd Neobenz-Micro-Wash-Plus-Pack-Cream Neutrogena-Acne-Mask Neutrogena-Healthy-Scalp-Shampoo Neutrogena-On-Spot-Acne-Treatment Norethin-1-35-E Norinyl-1-35 Nortrel-0-5-35 Nortrel-1-35 Nortrel-7-7-7 Novacet Nuox-Gel Occlusal-Hp-Liquid Ocella Ocudox-Convenience-Kit Oraxyl Ortho-Tri-Cyclen Ortho-Novum-1-35 Ortho-Novum-7-7-7 Oscion Oscion-Cleanser Ovcon-35 Ovcon-35-Fe Ovcon-50 Oxy-10-Balance Oxy-Balance Oxy-Balance-Deep-Pore-Cleanser-Liquid Oxy-Daily-Wash-Chill-Factor Oxy-Face-Scrub Oxy-10 P-S-Topical Pacnex Panixine Panoxyl-Bar Panoxyl-10 Panoxyl-5 Panoxyl-Aqua-Gel Panoxyl-Maximum-Strength-Foaming-Acne-Wash Pernox-Lotion Peroderm-7-Wash Persa-Gel Phillips-Milk-Of-Magnesia-Suspension Plexion Plexion-Cleanser Plexion-Cleansing-Cloths Plexion-Sct-Cream Plexion-Ts-Emulsion Prascion Prascion-Cleanser Prascion-Fc-Cloths Prascion-Ra Propa-P-H Propa-Ph-Acne-Med-Cleansing-Pads Propa-Ph-Acne-Med-Maximum-Strength-Liquid R-A-Acne-Topical Resinol-Topical Retin-A-Micro-Gel Retin-A-Cream Rezamid Romycin Rosac-Cream Rosac-Wash Rosaderm-Cleanser Rosanil Rosula-Foam Rosula-Cleanser Rosula-Clk-Kit Sal-Acid-Plaster-Topical Sal-Plant-Gel Salac Salactic-Film-Topical Salacyn-Lotion Salex-Lotion Salitop-Lotion Salkera-Foam Salvax-Foam Sastid-Soap Scalpicin-Scalp-Relief Se-10-5-Ss Se-Bpo-Wash Seba-Gel Sebucare Sebulex-Shampoo Septra Septra-Ds Smz-Tmp-Ds Solodyn Soluclenz-Rx Sotret Staticin-Topical Stieva-A-Cream-Forte-Topical Stieva-A-Cream-Topical Stri-Dex Stridex-Body-Focus-Cream Stridex-Maximum-Strength-Pads Sulfacet-R Sulfatol-10-4-Cleansing-Pads Sulfatol-C Sulfatol-Ss Sulfatrim-Suspension Sulfo-Lo Sulfoam Sulforcin Sulfoxyl-Regular-Lotion Sulfoxyl-Strong-Lotion Sulmasque Sulpho-Lac Sulpho-Lac-Soap Sulzee-Wash Sumadan Sumaxin-Wash Sumaxin-Ts-Emulsion Sumycin Suphera Syeda T-Stat Tazorac-Cream Thera-Sal-Topical Theramycin-Z Tilia-Fe Tinamed-Plantar-Pads Topicycline Topisulf Tretin-X-Cream Tri-Legest Tri-Legest-Fe Tri-Norinyl Tri-Previfem Tri-Sprintec Triaz-Cloths Trinessa Trinessa-Lo Vanoxide-Hc-Lotion Veltin Vestura Vibra-Tabs Vibramycin Wart-Off-Treatment Yasmin Yaz Z-Clinz-10 Z-Clinz-5 Zacare-4-Kit-Lotion Zaclir Zenchent-Fe Zencia-Wash Zeosa Zetacet-Emulsion Zetacet-Wash Ziana Zoderm-Cleanser
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Juvederm


In the US, Juvederm (dermal filler topical) is used to treat Facial Wrinkles.

US matches:

Juvederm Ingredient matches for Juvederm Hyaluronic Acid

Hyaluronic Acid is reported as an ingredient of Juvederm in the following countries:

Australia

International Drug Name Search


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eflornithine topical


Generic Name: eflornithine topical (ee FLOOR nih theen)
Brand Names: Vaniqa

What is eflornithine topical?

Eflornithine interferes with a chemical in the hair follicles of the skin. This results in slower hair growth where eflornithine topical is applied.

Eflornithine topical is used to reduce unwanted facial hair in women. Eflornithine topical does not permanently remove hair or "cure" unwanted facial hair. Eflornithine topical will help you manage your condition and improve your appearance.

Eflornithine topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about eflornithine topical? Eflornithine topical is for external use only.

Continue to use eflornithine topical even if you do not see immediate results. Reduction in facial hair occurs gradually. Improvement may be seen as early as 4 to 8 weeks of treatment, however it may take longer in some individuals. If no improvement is seen after 6 months of use, treatment with eflornithine topical should be discontinued. Hair growth may return to pretreatment levels approximately 8 weeks after discontinuation of treatment with eflornithine topical.

Who should not use eflornithine topical? Do not use eflornithine topical if you have had an allergic reaction to it in the past. Eflornithine topical is in the FDA pregnancy category C. This means that it is not known whether eflornithine topical will harm an unborn baby. Do not use this medication without first talking to your doctor if you are pregnant. It is also not known whether eflornithine passes into breast milk. Do not use eflornithine topical without first talking to your doctor if you are breast-feeding a baby. Eflornithine topical has not been approved for use by children younger than 12 years of age. How should I use eflornithine topical? Apply eflornithine topical exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Eflornithine topical does not permanently remove hair or "cure" unwanted facial hair. It is not a hair remover (depilatory). You will need to continue using your current hair removal techniques. Eflornithine topical will help you manage your condition and improve your appearance.

Eflornithine topical is for external use only.

Eflornithine topical is usually applied twice daily, at least eight hours apart, or as directed by your doctor.

Wash your hands before and after each application of eflornithine topical.

Remove any facial hair that is present using your current hair removal techniques. Wait at least 5 minutes after hair removal before applying eflornithine topical. Apply a thin layer of eflornithine topical to the affected areas of the face and nearby affected areas under the chin and rub it in thoroughly.

Cosmetics or sunscreen may be used after applying eflornithine topical, but you should wait a few minutes to allow the treatment to be absorbed before applying them.

Do not wash the treatment areas for at least 4 hours after application of eflornithine topical. Avoid getting this medication in your eyes, nose, or mouth. If this occurs, wash the area with water. If eflornithine topical gets in your eyes, rinse them thoroughly with water and contact your doctor.

Eflornithine topical may cause temporary redness, rash, burning, stinging, or tingling, especially if it is applied to broken or irritated skin. If irritation develops, reduce the application of eflornithine topical to once a day. If irritation continues, stop using eflornithine topical and contact your doctor.

Continue to use eflornithine topical even if you do not see immediate results. Reduction in facial hair occurs gradually. Improvement may be seen as early as 4 to 8 weeks of treatment, however it may take longer in some individuals. If no improvement is seen after 6 months of use, treatment with eflornithine topical should be discontinued. Hair growth may return to pretreatment levels approximately 8 weeks after discontinuation of treatment with eflornithine topical.

Store eflornithine topical at room temperature away from moisture and heat. Do not allow the medication to freeze. What happens if I miss a dose?

If you miss a dose of eflornithine topical, skip the dose you missed and apply your next regularly scheduled dose as directed. Do not apply a double dose of this medication or try to "make up" a missed dose.

What happens if I overdose?

An overdose of eflornithine topical is not likely to occur. If the cream has been ingested, or if you suspect an overdose has occurred, contact your doctor, hospital emergency room, or poison control center for advice.

What should I avoid while using eflornithine topical? Avoid getting this medication in your eyes, nose, or mouth. If this occurs, wash the area with water. If eflornithine topical gets in your eyes, rinse thoroughly with water and contact your doctor. Eflornithine topical side effects

Eflornithine topical may cause temporary redness, rash, burning, stinging, or tingling, especially if it is applied to broken or irritated skin. If irritation develops, reduce the application of eflornithine topical to once a day. If irritation continues, stop using eflornithine topical and contact your doctor.

Hair bumps (folliculitis) may also occur. If these continue, contact your doctor.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Eflornithine topical Dosing Information

Usual Adult Dose for Hirsutism:

Apply a thin layer of eflornithine topical cream to affected areas of the face and adjacent involved areas under the chin and rub in thoroughly. Do not wash treated area for at least 4 hours. Use twice a day, allowing at least 8 hours between applications or as directed by a physician.
Continue to use hair removal techniques as needed in conjunction with eflornithine. Apply eflornithine at least 5 minutes after hair removal. Cosmetics or sunscreens may be applied over treated areas after cream has dried.

What other drugs will affect eflornithine topical?

Before using eflornithine topical, talk to your doctor if you are taking any other prescription or over-the-counter medications, especially if you are using any other topical preparations. You may not be able to use eflornithine topical, or you may require a dosage adjustment or special monitoring during treatment.

Drugs other than those listed here may also interact with eflornithine topical. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines.

More eflornithine topical resources Eflornithine topical Side Effects (in more detail) Eflornithine topical Dosage Eflornithine topical Use in Pregnancy & Breastfeeding Eflornithine topical Support Group 8 Reviews for Eflornithine - Add your own review/rating Vaniqa Monograph (AHFS DI) Vaniqa Topical Advanced Consumer (Micromedex) - Includes Dosage Information Vaniqa Cream MedFacts Consumer Leaflet (Wolters Kluwer) Vaniqa Consumer Overview Compare eflornithine topical with other medications Hirsutism Where can I get more information? Your pharmacist has additional information about eflornithine topical written for health professionals that you may read.

See also: eflornithine side effects (in more detail)


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Topical acne agents


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Topical acne agents are applied on the skin to treat mild acne. They contain medicines, which control acne on the surface but may not treat the actual cause beneath the skin. Topical acne formulations either contain antibiotics that destroy or inhibit the growth of bacteria that form the pustules or they contain agents that help renew the skin more quickly and therefore reduce acne.

See also

Medical conditions associated with topical acne agents:

AcneBacterial Skin InfectionBacterial VaginitisDermatological DisordersLichen SclerosusNecrobiosis Lipoidica DiabeticorumPerioral DermatitisPhotoaging of the SkinRosaceaSkin InfectionWarts Drug List:/tags/avita-cream/
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Wind-Eze Tablets


1. Name Of The Medicinal Product

Wind-Eze

2. Qualitative And Quantitative Composition

Simeticone [Equivalent to Poly(Dimethylsiloxane)], 11.57% w/w, approx. 125.00mg

3. Pharmaceutical Form

Chewable tablets for oral administration.

4. Clinical Particulars 4.1 Therapeutic Indications

Antiflatulent defoaming agent for the symptomatic relief of flatulence, wind pains, bloating, abdominal distension and other similar symptoms associated with gastrointestinal gas.

4.2 Posology And Method Of Administration

Adults, elderly and children over 12 years:

One tablet to be taken three or four times daily or as required for relief, after meals and upon retiring. The tablets are to be chewed before swallowing.

Not recommended for children under 12 years.

4.3 Contraindications

The product should not be used in patients with known hypersensitivity to any of the ingredients.

4.4 Special Warnings And Precautions For Use

If symptoms persist or worsen, medical advice should be sought.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

Since simeticone is not absorbed by the gastro intestinal tract, Wind-Eze may be taken during pregnancy and lactation.

4.7 Effects On Ability To Drive And Use Machines

None known.

4.8 Undesirable Effects

Rarely hypersensitivity reactions such as rash, pruritus, facial oedema, tongue oedema, respiratory difficulty.

4.9 Overdose

In the unlikely event of deliberate or accidental overdosage, treat symptoms on appearance. There are no special procedures recommended.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

Physiologically simeticone is extremely inert, and therefore it will not be pharmacologically active.

5.2 Pharmacokinetic Properties

Simeticone (activated dimeticone) is not absorbed following oral administration. It acts by changing the surface tension of gas bubbles, causing them to coalesce.

5.3 Preclinical Safety Data

Simeticone is physiologically inert and considered to be non-toxic. It is not absorbed following oral administration, nor is it pharmacologically active. Preclinical data reveal no hazard for humans.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Dextrates (hydrated) USNF

Sorbitol Crystalline EP

Tribasic Calcium Phosphate (Powder) USNF

Citric Acid Anhydrous (Powder) EP

Natural and artificial peppermint flavour No. 517

(Spray dried) HSE

Talc (purified) EP

Non-pareil seeds (Starch/Sucrose) HSE

6.2 Incompatibilities

None known.

6.3 Shelf Life

3 years in PVC/PVDC Al foil blister packs. 3 years in PVC/PE/Aclar Al. foil blister packs.

6.4 Special Precautions For Storage

Store below 25oC.

Store in a dry place.

6.5 Nature And Contents Of Container

Blister packs of construction 190 ?m PVC (product contact side)/51?m PE/38?m aclar and 25?m aluminium foil with vinyl sealing coat (product contact side).

or

Blister packs of construction 250?m PVC (product contact side)/PVDC 60 g/m2 and 20 ?m aluminium foil with vinyl heat sealing coat (product contact side).

Pack sizes: 4, 10, 20, 30, 50.

6.6 Special Precautions For Disposal And Other Handling

Not applicable.

7. Marketing Authorisation Holder

Stafford-Miller Limited

980 Great West Road

Brentford

Middlesex

TW8 9GS

Trading as GlaxoSmithKline Consumer Healthcare, Brentford TW8 9GS, U.K.

8. Marketing Authorisation Number(S)

PL 00036/0084

9. Date Of First Authorisation/Renewal Of The Authorisation

25th May 2001

10. Date Of Revision Of The Text

February 2008


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Stanhexidine Solution


Generic Name: chlorhexidine (Topical application route)

klor-HEX-i-deen

Commonly used brand name(s)

In the U.S.

Betasept Biopatch w/Chlorhexidine Gluconate Chlorostat Dyna-Hex Dyna-Hex2 Hibiclens Hibistat Operand Chg Surgical Scrub Brush Operand Chlorhexidine Gluconate Operand Closed Loop Chg Scrub

In Canada

Stanhexidine Solution Stanley Chlorhexidine Tinted Stanley Chlorhexidine Untinted

Available Dosage Forms:

Dressing Gel/Jelly Lotion Solution Liquid Pad Sponge Cream

Therapeutic Class: Antibacterial Cleansing Agent

Uses For Stanhexidine Solution

Chlorhexidine belongs to a group of medicines called antiseptic antibacterial agents. It is used to clean the skin after an injury, before surgery, or before an injection. Chlorhexidine is also used to clean the hands before a procedure. It works by killing or preventing the growth of bacteria on the skin.

Before Using Stanhexidine Solution

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Because of chlorhexidine's potential for causing excessive skin irritation and the risk of increased absorption through the skin, use in children less than 2 months of age is not recommended.

Geriatric

No information is available on the relationship of age to the effects of chlorhexidine in geriatric patients.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Deep or open skin wounds—Some products should not be used for this condition. Use the medicine only as directed by your doctor. Proper Use of chlorhexidine

This section provides information on the proper use of a number of products that contain chlorhexidine. It may not be specific to Stanhexidine Solution. Please read with care.

Some of the chlorhexidine products will be used in a hospital or clinic setting. The medicine will be applied by a nurse or other trained health professional.

You may be instructed to use this medicine at home. It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause irritation of the skin.

Different forms of the medicine are used in different ways. Be sure you understand the directions for the product you are given before you use it. Ask your doctor or pharmacist if you have any questions.

Follow your doctor's instructions about how to clean and care for your skin before and after you use this medicine. Make sure you understand all of the directions, and ask questions if you find something is not clear.

Chlorhexidine should only be used on the skin. Do not swallow it or get it in the eyes, ears, mouth, or nose. Do not use it on the genital area (sex organs) or anal area. If it does get on these areas, rinse it off right away.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage form (hand rinse or wipe, solution, or swabstick applicator): To clean the hands (eg, Hibistat®): The Hibistat® product contains large amounts of alcohol (70%) and is flammable. Apply the medicine in a well-ventilated place and do not use it while you are smoking. Adults, teenagers, and children 2 months of age and older: Wash your hands with soap and water. Dry your hands with a towel. Rub the hands with the hand wipe for 15 seconds. Make sure to use the wipe under the fingernails and between the fingers. The medicine will dry quickly so you should not use a towel for drying. Do not wet your hands a second time. Pour 1 teaspoonful (5 milliliters) of the hand rinse in your cupped hand. Rub the hands together for 15 seconds. Make sure to apply the rinse under the fingernails and between the fingers. The medicine will dry quickly so you should not use a towel for drying. Do not wet your hands a second time. Children younger than 2 months of age—Use is not recommended. To clean the skin or a wound (eg, Betasept®, Hibiclens®): Adults, teenagers, and children 2 months of age and older—Rinse the area to be cleaned with water. Apply the smallest amount of liquid needed to cover the skin or wound area and wash gently. Thoroughly rinse the area again with water. Children younger than 2 months of age—Use is not recommended. To use before surgery or an injection (eg, Chloraprep®): The Chloraprep® product contains large amounts of alcohol (70%) and is flammable. Do not use it on skin areas that have cuts or scrapes. Apply the medicine in a well-ventilated place and do not use it while you are smoking. Adults, teenagers, and children 2 months of age and older: Open the pouch and use the handle to remove the swabstick applicator. Do not touch the applicator tip. Rub the applicator on the skin with the flat side against the skin. Use a back and forth motion for 30 seconds. Make sure the skin is completely wet. Let the skin air dry for one minute. Do not use a towel for drying. Do not cover the treated area until the skin is completely dry. This is usually one minute or longer for hairless skin. If you must apply the medicine to a hairy area of the body, wipe the area with a towel to remove extra medicine. Children younger than 2 months of age—Use is not recommended. Storage

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

The Chloraprep® and Hibistat® products contain large amounts of alcohol (70%) and are flammable. Do not store them near a flame, heater, or electrical device.

Precautions While Using Stanhexidine Solution

Check with your doctor if your skin problem becomes worse. Call your doctor if you have skin irritation that does not go away, such as redness, itching, or burning in the area where you used this medicine.

This medicine should not be used for an extended period of time on large areas of the body. Follow your doctor's instructions about how long to use this medicine.

This medicine may cause serious and permanent injury when placed in the eyes, ears, or mouth. Carefully follow all instructions before using this medicine to prevent serious side effects.

This medicine may cause a brown stain on clothing when chlorine is also present. These stains may not be removed by regular washing. Use only non-chlorine products to wash or bleach fabrics exposed to this medicine. If the medicine has directions on the package about washing fabrics, follow them carefully.

The Chloraprep® and Hibistat® products contain large amounts of alcohol (70%) and are flammable. Do not use them or store them near a flame, heater, or electrical device. Do not use the medicine while you are smoking. Apply the medicine in a well-ventilated place.

Stanhexidine Solution Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known Blistering, burning, itching, peeling, skin rash, redness, swelling, or other signs of irritation on the skin swelling of the face, hands, or feet trouble breathing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Stanhexidine side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Stanhexidine Solution resources Stanhexidine Solution Side Effects (in more detail)Stanhexidine Solution Use in Pregnancy & BreastfeedingStanhexidine Solution Support Group1 Review for Stanhexidine - Add your own review/rating Compare Stanhexidine Solution with other medications GingivitisMucositisPeriodontitis
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nicardipine


Generic Name: nicardipine (nye KAR di peen)
Brand names: Cardene, Cardene SR, Cardene IV

What is nicardipine?

Nicardipine is in a class of drugs called calcium channel blockers. Nicardipine relaxes (widens) your blood vessels, which makes it easier for the heart to pump and reduces its workload.

Nicardipine is used to treat hypertension (high blood pressure) and angina (chest pain).

Nicardipine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about nicardipine? Do not stop taking nicardipine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse. Do not crush, chew, or break the extended-release (SR) capsules. Swallow them whole. They are specially formulated to release the medication slowly in the body. What should I discuss with my healthcare provider before taking nicardipine?

Before taking nicardipine, tell your doctor if you have

kidney disease; liver disease; or

another disease of the heart or blood vessels such as sick sinus syndrome, aortic stenosis, heart failure, low blood pressure, or coronary artery disease.

You may not be able to take nicardipine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Nicardipine is in the FDA pregnancy category C. This means that it is not known whether nicardipine will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Nicardipine passes into breast milk and may affect a nursing infant. Do not take nicardipine without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from nicardipine. Your doctor may prescribe a lower dose of this medication. How should I take nicardipine?

Take nicardipine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Do not crush, break, or chew the extended-release (SR) capsules. Swallow them whole. They are specially formulated to release the medication slowly in the body. Do not stop taking nicardipine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse.

Grapefruit and grapefruit juice may interact with nicardipine. The interaction could have potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Store nicardipine at room temperature away from moisture and heat.

See also: Nicardipine dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose? Seek emergency medical attention.

Symptoms of a nicardipine overdose include dizziness, weakness, chest pain, shortness of breath, fainting, an unusually fast or slow heartbeat, coma, slurred speech, and confusion.

What should I avoid while taking nicardipine?

Grapefruit and grapefruit juice may interact with nicardipine. The interaction could have potentially dangerous effects. Discuss the use of grapefruit and grapefruit juice with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Follow any recommendations your doctor makes about diet or exercise.

Use caution when you stand or sit up from a lying position, especially if you wake up during the night. You may become dizzy when changing positions. Use alcohol cautiously. Alcohol may further lower blood pressure and increase drowsiness or dizziness while taking nicardipine. Nicardipine side effects If you experience any of the following serious side effects, stop taking nicardipine and contact your doctor immediately or seek emergency medical treatment:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

unusually fast or slow heartbeats;

fainting or severe dizziness;

abnormal behavior or psychosis;

chest pain or worsening angina;

jaundice (yellowing of the skin or eyes); or

swelling of the legs or ankles.

Other, less serious side effects may be more likely to occur. Continue to take nicardipine and talk to your doctor if you experience

unusual headache, fatigue, or tiredness;

dizziness;

flushing;

rash;

insomnia;

vivid or abnormal dreams;

increased urination;

dry mouth;

nausea or constipation; or

nervousness or tremor.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Nicardipine Dosing Information

Usual Adult Dose for Hypertension:

Oral:
Immediate release:
Initial dose: 20 mg orally 3 times a day
Maintenance dose: 20 to 40 mg orally 3 times a day
Sustained release:
Initial dose: 30 mg orally twice a day
Maintenance dose: 30 to 60 mg orally twice a day
IV infusion:
As substitute for oral therapy:
The following IV infusion rates are required to produce an average plasma level corresponding to a given oral dose at steady state:
20 mg orally every 8 hours is equivalent to 0.5 mg/hour via IV infusion
30 mg orally every 8 hours is equivalent to 1.2 mg/hour via IV infusion
40 mg orally every 8 hours is equivalent to 2.2 mg/hour via IV infusion
For initiation of therapy in patient not receiving oral nicardipine:
Initial dose: 5 mg/hour by IV infusion
The infusion rate may be increased by 2.5 mg/hour every 5 to 15 minutes (rapid and gradual titration, respectively) up to a maximum of 15 mg/hour, until desired blood pressure reduction is achieved. The infusion rate should be decreased to 3 mg/hour following achievement of the blood pressure goal using rapid titration.
Maintenance dose: The rate of infusion should be adjusted as needed to maintain desired response.
If oral nicardipine is to be used after IV nicardipine, the first dose should be administered 1 hour prior to discontinuation of the IV infusion.

Usual Adult Dose for Angina Pectoris Prophylaxis:

Oral:
Immediate release:
Initial dose: 20 mg orally 3 times a day
Maintenance dose: 20 to 40 mg orally 3 times a day
Sustained release:
Initial dose: 30 mg orally twice a day
Maintenance dose: 30 to 60 mg orally twice a day
IV infusion:
The following IV infusion rates are required to produce an average plasma level corresponding to a given oral dose at steady state:
20 mg orally every 8 hours is equivalent to 0.5 mg/hr IV infusion
30 mg orally every 8 hours is equivalent to 1.2 mg/hr IV infusion
40 mg orally every 8 hours is equivalent to 2.2 mg/hr IV infusion
Initiation of therapy: 5 mg/hour by IV infusion
May increase by 2.5 mg/hour every 5 to 15 minutes up to a maximum of 15 mg/hour

Usual Adult Dose for Congestive Heart Failure:

Oral:
Immediate release:
Initial dose: 20 mg orally 3 times a day
Maintenance dose: 20 to 40 mg orally 3 times a day
Sustained release:
Initial dose: 30 mg orally twice a day
Maintenance dose: 30 to 60 mg orally twice a day
IV infusion:
The following IV infusion rates are required to produce an average plasma level corresponding to a given oral dose at steady state:
20 mg orally every 8 hours is equivalent to 0.5 mg/hr IV infusion
30 mg orally every 8 hours is equivalent to 1.2 mg/hr IV infusion
40 mg orally every 8 hours is equivalent to 2.2 mg/hr IV infusion
Initiation of therapy: 5 mg/hour by IV infusion
May increase by 2.5 mg/hour every 5 to 15 minutes up to a maximum of 15 mg/hour

What other drugs will affect nicardipine?

Before taking nicardipine, tell your doctor if you are taking any of the following drugs:

another heart medication to treat the same or another condition;

cimetidine (Tagamet, Tagamet HB); or

cyclosporine (Sandimmune, Neoral).

You may not be able to take nicardipine, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with nicardipine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

More nicardipine resources Nicardipine Side Effects (in more detail) Nicardipine Dosage Nicardipine Use in Pregnancy & Breastfeeding Drug Images Nicardipine Drug Interactions Nicardipine Support Group 0 Reviews for Nicardipine - Add your own review/rating nicardipine Advanced Consumer (Micromedex) - Includes Dosage Information Cardene Prescribing Information (FDA) Cardene MedFacts Consumer Leaflet (Wolters Kluwer) Cardene IV Advanced Consumer (Micromedex) - Includes Dosage Information Cardene SR Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer) Cardene SR Prescribing Information (FDA) Nicardipine Prescribing Information (FDA) Nicardipine Monograph (AHFS DI) Nicardipine MedFacts Consumer Leaflet (Wolters Kluwer) Compare nicardipine with other medications Angina Pectoris Prophylaxis Heart Failure High Blood Pressure Where can I get more information? Your pharmacist can provide more information about nicardipine.

See also: nicardipine side effects (in more detail)


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Salicylic Acid


Class: Keratolytic Agents
ATC Class: D01AE12
VA Class: DE500
CAS Number: 69-72-7
Brands: Aveeno Clear Complexion, Clearasil, Compound W, Denorex, Dermarest, DHS Sal, Dr Scholl’s, DuoFilm, Freezone, Hydrisalic, Ionil Plus, Keralyt, Kerasal, Mediplast, Meted, MG 217 Sal-Acid, Neutrogena Rapid Clear, Neutrogena T-Sal, Noxzema, Occlusal, Oxy, P&S, Psoriasin, Sal-Acid, Salactic, Salex, Sal-Plant, Sebasorb , Stridex, Tarsum , Trans-Ver-Sal, Versiclear, Wart-off

Introduction

Keratolytic agent; derivative of benzoic acid.a o

Uses for Salicylic Acid Acne

Salicylic acid is used alone or in combination with other drugs (e.g., resorcinol, sulfur) for the symptomatic treatment of acne.a c k

Seborrheic Dermatitis and Psoriasis

Salicylic acid is used for self-medication to control seborrheic dermatitis of the body and scalp, psoriasis of the body and scalp, dandruff, and other scaling dermatoses.a f l m o q r s

Cream, lotion, and gel (6% salicylic acid) used to aid in the exfoliation of dry, scaly skin associated with psoriasis.l o p

Hyperkeratosis

Salicylic acid is used topically as self-medication for its keratolytic and caustic effect in the removal of common and plantar warts;a d h j l also used to remove corns and calluses.a e i n o p

Salicylic acid is used for treatment of localized hyperkeratosis that occurs on the palms and soles.a l o

Tinea Versicolor

Salicylic acid is used in combination with an antifungal (sodium thiosulfate) for the treatment of tinea versicolor (Malassezia furfur) infection.g

Salicylic Acid Dosage and Administration General

Consult a clinician prior to initiating self-medication for a condition that covers a large area of the body.f m q r

Administration Topical Administration

Apply topically to the skin as a cake, cream, gel, lotion, ointment, pledget, plaster, shampoo, or solution.h i j k l m n o q r s t

For external use only;c d e f h i j k not for ophthalmic, oral, or intravaginal use.l o p If contact with the eye(s) occurs, wash thoroughly with water.d e f h k m n q r

Rinse hands thoroughly after topical application, unless hands are being treated.l o p

Do not use systemically because of severe irritating effect on GI mucosa and other tissues.a b

Apply salicylic acid 6% cream (Salex), lotion (Salex), or gel (Keralyt, Hydrisalic) topically to affected area(s) at bedtime.l o p Hydrate affected area of skin (e.g., with wet packs or baths) for ?5 minutes prior to application and cover with occlusive dressing.l o p In the morning, wash affected area of skin; may apply a bland emollient if affected skin is irritated or excessively dry.l o If occlusion is not possible, may apply more frequently.l o p However, excessive, repeated application does not necessarily increase therapeutic benefit and may increase risk of adverse local effects and salicylism.l (See Salicylate Toxicity under Cautions.)

Acne (Self-medication)

Apply topically using appropriate preparations containing salicylic acid 0.5–2%.c

Cleanse and dry the affected area prior to topical application.c

Apply a thin layer of appropriate salicylic acid preparation (e.g., cream, gel, lotion) to affected areas.c

Apply cake or cleansing solution with water, in place of regular soap; rinse thoroughly with warm water and pat dry.c k

Seborrheic Dermatitis and Psoriasis (Self-medication)

Apply topically using appropriate preparations containing salicylic acid 1.8–3%.f

Apply cream, lotion, ointment, gel, or solution to affected areas of skin.f

Apply preparations formulated as soaps or shampoo to affected area(s) in place of regular soap or shampoo.f m

Hyperkeratosis

Corn and Callus Removal (Self-medication): Apply topically using appropriate preparations containing salicylic acid 12–40% (e.g., plaster, solution in flexible collodion) or 3% (gel).e

Do not apply on irritated or infected skin.e n

Cleanse and dry the affected area prior to topical application.e i n

Trim plaster to fit completely over the callus or corn and apply.e i

Apply a small amount of solution in flexible collodion with an applicator to sufficiently cover corn or callus and allow to dry.e n

Apply a small amount of solution or gel (e.g., 1 drop at a time) with an applicator to sufficiently cover corn or callus; allow to dry.e h

May soak affected area(s) in warm water for 5 minutes to aid in corn or callus removal.e i n

Wart Removal (Self-medication): Apply topically using appropriate preparations containing salicylic acid 12–40% (plaster) or 5–17% (solution in flexible collodion).d h j

Do not use on moles, birthmarks, warts with hair(s) growing from them, genital warts, or warts on the face or mucous membranes.d h j

Do not apply on irritated, reddened, or infected skin.d

Cleanse and dry the affected area prior to topical application; may soak affected area(s) in warm water for 5 minutes.d

Trim plaster to fit completely over the wart and apply.d j

Prior to application of plaster in a karaya gum and polyethylene glycol vehicle (Trans-Ver-Sal), gently smooth wart with emery board, and carefully apply a drop of warm water to wart, using a cotton-tipped applicator. Trim plaster to completely fit over wart; if necessary, secure plaster in place with medical tape.j Ensure that the plaster does not touch unaffected surrounding skin.j

Apply a small amount of solution or gel (e.g., one drop at a time) with an applicator to sufficiently cover wart(s); allow to dry.d h

Dosage Pediatric Patients Acne Topical

Self-medication: Apply appropriate 0.5–2% salicylic acid preparation 1–3 times daily.c Initially, apply once daily, then gradually increase to 2 or 3 times daily, if necessary.c If dryness or peeling occurs, reduce application to once daily or every other day.c

Seborrheic Dermatitis and Psoriasis Scalp Topical

Self-medication for children >2 years of age: Apply 3% salicylic acid solution to affected area(s) of the scalp 1–4 times daily or as directed by a clinician.f s

Apply 2–3% salicylic acid shampoo to wet hair and massage into scalp.m Leave lather on scalp for 2 minutes, then rinse thoroughly; repeat if necessary.m Use at least twice weekly or as directed by a clinician.f m

Apply combination (salicylic acid and coal tar) shampoo to scalp evenly before bathing.u Allow to remain on scalp for 5 minutes; add water and lather, and then rinse thoroughly.u Gradually increase treatment times to 1 hour, or as directed by a clinician.u Alternatively, apply to wet hair and lather; allow to remain on scalp for up to 10 minutes, then rinse.u Use daily until itching and flaking improve, then reduce to twice weekly or as directed by a clinician.u

Body (Excluding Scalp) Topical

Self-medication for children >2 years of age: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, ointment, lotion, gel) to affected area(s) 1–4 times daily or as directed by a clinician.f q r

Apply 2–3% salicylic acid shampoo to affected area(s) of the body in place of soap.m Leave lather on for 2 minutes, then rinse thoroughly; repeat if necessary.m Use at least twice weekly or as directed by a clinician.f m

Children ?2 years old: Apply 6% salicylic acid gel, cream, or lotion to affected area(s) once daily at bedtime and occlude.l o p When improvement occurs, apply occasionally to maintain remission.l o p In areas where occlusion is difficult or impossible, apply more frequently.l o p

Hyperkeratosis Corn and/or Callus Removal Topical

Children ?2 years of age: Apply 6% salicylic acid gel, cream, or lotion to affected area(s) once daily at bedtime and occlude.l o p In areas where occlusion is difficult or impossible, apply more frequently.o

Self-medication for children >12 years of age: Apply 3% salicylic acid gel to calloused skin once daily or as directed by a clinician.t

Wart Removal Topical

Children ?2 years of age: Apply 15% salicylic acid plaster in a karaya gum and polyethylene glycol vehicle once daily at bedtime; leave in place for ?8 hours, then remove and discard.d j Repeat every 24 hours as needed until wart is completely removed or for up to 12 weeks.d j

Tinea Versicolor Topical

Children >12 years of age: Apply combination lotion (salicylic acid 1% and sodium thiosulfate 25%) in a thin film to all affected area(s) twice daily or as directed by a clinician.v

Adults Acne Topical

Self-medication: Apply appropriate 0.5–2% salicylic acid preparation 1–3 times daily.c Initially, apply once daily, then gradually increase to 2 or 3 times daily, if necessary.c If dryness or peeling occurs, reduce application to once daily or every other day.c

Seborrheic Dermatitis and Psoriasis Scalp Topical

Self-medication: Apply 3% salicylic acid solution to affected area(s) of the scalp 1–4 times daily or as directed by a clinician.f s

Self-medication: Apply 2–3% salicylic acid shampoo to wet hair and massage into scalp.f m Leave lather on for several minutes, then rinse thoroughly; repeat if necessary.f m Use at least twice weekly or as directed by a clinician.f m

Apply combination (salicylic acid and coal tar) shampoo to scalp evenly before bathing.u Allow to remain on scalp for 5 minutes and then rinse thoroughly.u Gradually increase treatment times to 1 hour, or as directed by a clinician.u Alternatively, apply to wet hair; allow to remain on scalp for up to 10 minutes, then rinse.u Use daily until itching and flaking improve, then reduce to twice weekly or as directed by a clinician.u

Body (Excluding Scalp) Topical

Self-medication: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, ointment, lotion, gel) to affected area(s) 1–4 times daily or as directed by a clinician.f q r

Self-medication: Apply 2–3% salicylic acid shampoo to affected area(s) of the body in place of soap.m Leave lather on for 2 minutes, then rinse thoroughly; repeat if necessary.m Use at least twice weekly or as directed by a clinician.f m

Apply 6% salicylic acid gel, cream, or lotion to affected area(s) once daily at bedtime and occlude.l o p When improvement occurs, apply occasionally to maintain remission.l o p In areas where occlusion is difficult or impossible, apply more frequently.l o p

Hyperkeratosis Corn and/or Callus Removal Topical

Self-medication: Apply 12–40% salicylic acid plaster to corn or callus and cover with cushion provided by manufacturer.e i After 48 hours, remove cushion and plaster.e i May cover with cushion provided by manufacturer.i Repeat every 48 hours as needed until corn or callus is removed, for up to 14 days.e i

Self-medication: Apply 12–17.6% salicylic acid solution or gel in flexible collodion (e.g., 1 drop at a time) to sufficiently cover corn or callus.e n Repeat once or twice daily as needed for up to 14 days.e n

Self-medication: Apply 3% salicylic acid gel to calloused skin once daily or as directed by a clinician. t

Apply 6% salicylic acid gel, cream, or lotion to the affected area(s) at bedtime and occlude.l o p In areas where occlusion is difficult or impossible, apply more frequently.p o

Wart Removal Topical

Self-medication: Apply 12–40% salicylic acid plaster to wart.d After 48 hours, remove and repeat as needed until wart is completely removed or for up to 12 weeks.d

Self-medication: Apply 5–17% salicylic acid solution or gel in flexible collodion (e.g., 1 drop at a time) to sufficiently cover wart(s).d h Repeat once or twice daily for up to 12 weeks.d h

Apply 15% salicylic acid plaster in a karaya gum and polyethylene glycol vehicle to wart(s) once daily at bedtime; leave in place for ?8 hours, then remove and discard.d j Repeat every 24 hours as needed until wart is completely removed for up to 12 weeks.d j

Tinea Versicolor Topical

Self-medication: Apply combination lotion (salicylic acid 1% and sodium thiosulfate 25%) in a thin film to affected areas twice daily or as directed by a clinician.g

Prescribing Limits Pediatric Patients Acne Topical

Self-medication: Apply a maximum 3 times daily.c

Seborrheic Dermatitis and Psoriasis Scalp Topical

Self-medication for children >2 years of age: Apply 3% salicylic acid solution a maximum 4 times daily or as directed by a clinician.f s

Body (Excluding Scalp) Topical

Self-medication for children >2 years of age: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, lotion, ointment, gel) a maximum 4 times daily or as directed by a clinician.f

Adults Acne Topical

Self-medication: Apply a maximum 3 times daily.c

Seborrheic Dermatitis and Psoriasis Scalp Topical

Self-medication: Apply 3% salicylic acid solution for a maximum 4 times daily or as directed by a clinician.f s

Body (Excluding Scalp) Topical

Self-medication: Apply appropriate 1.8–3% salicylic acid preparation (e.g., cream, lotion, ointment, gel) a maximum 4 times daily or as directed by a clinician.f

Hyperkeratosis Corn and/or Callus Removal Topical

Self-medication: Apply plaster or solution or gel in flexible collodion a maximum 14 days.e i n

Wart Removal Topical

Self-medication: Apply plaster or solution or gel in flexible collodion a maximum 12 weeks.d h j

Special Populations Hepatic Impairment

No specific dosage recommendations at this time; however, manufacturer recommends that treatment area should be limited.l o

Renal Impairment

No specific dosage recommendations at this time; however, manufacturer recommends that treatment area should be limited.l o

Cautions for Salicylic Acid Contraindications

Known sensitivity to salicylic acid or any other ingredient in the formulation.l o

6% salicylic acid cream, lotion, and gel: Children <2 years of age.l o

Warnings/Precautions Warnings Salicylate Toxicity

Risk of salicylate toxicity (e.g., nausea, vomiting, dizziness, loss of hearing, tinnitus, lethargy, hyperpnea, diarrhea, psychic disturbances) after prolonged or excessive topical use over large areas.l o p If salicylic acid toxicity occurs, immediately discontinue; administer fluids to promote urinary excretion, and administer sodium bicarbonate (oral or IV) if clinically necessary.l o

Avoid other salicylates (e.g., aspirin, salicylate athletic creams) to minimize exposure to salicylic acid.l o (See Interactions under Cautions.)

Use of Fixed Combinations

When used in fixed combination with urea, coal tar, and sodium thiosulfate, consider the cautions, precautions, and contraindications associated with these agents.g u

General Precautions Topical Effects

Possible excessive erythema or scaling if applied to open skin lesions.l o p

If excessive burning, irritation, stinging, or peeling occurs, discontinue use and consult a clinician.g o

Possible necrosis of normal skin with overuse.a

Concomitant Illnesses

Do not use salicylic acid wart, corn, and callus removal preparations in patients with diabetes or with poor blood circulation.d h n

Specific Populations Pregnancy

Category C.l o

Lactation

Discontinue nursing or the drug.l o If used by nursing women, avoid applying to the chest area.l

Pediatric Use

Salicylic acid 6% cream, lotion, and gel and 15% plaster not recommended in children <2 years of age.l j o (See Contraindications.)

Increased risk of salicylate toxicity with prolonged, excessive use in children <12 years of age.l o Limit treatment area and monitor for possible signs of salicylate toxicity.l o (See Salicylate Toxicity under Cautions.)

Use of salicylates in children with varicella infection or influenza-like illnesses reportedly is associated with an increased risk of developing Reye’s syndrome.b l o US Surgeon General, AAP Committee on Infectious Diseases, FDA, and other authorities advise that salicylates not be used in children and teenagers with varicella or influenza, unless directed by a clinician.b l o

Hepatic Impairment

Possible salicylate toxicity after prolonged topical use over large areas, especially in patients with substantial hepatic impairment.l o p Limit treatment area and monitor for possible signs of salicylate toxicity.l o (See Salicylate Toxicity under Cautions.)

Renal Impairment

Possible salicylate toxicity after prolonged topical use over large areas, especially in patients with substantial renal impairment.l o p Limit treatment area and monitor for possible signs of salicylate toxicity.l o (See Salicylate Toxicity under Cautions.)

Common Adverse Effects

Erythema,l o p scaling,l o p burning,g o stinging,g o peeling.c

Interactions for Salicylic Acid Topical Acne Preparations

Cumulative irritant or drying effect.c k If excessive dryness occurs, use only one topical medication unless directed by a clinician.c

Topical Salicylate Preparations

Increased risk of salicylate toxicity.l o

Protein-bound Drugs

Potential for salicylate to displace or to be displaced by other protein-bound drugs.b l o

Specific Drugs

Drug

Interaction

Comments

Acidifying agents

Drugs that decrease urine pH may decrease salicylate excretionl

Anticoagulants (warfarin, heparin)

Increased risk of bleedingb l o

May displace warfarin from protein-binding sites, leading to prolongation of PT and bleeding timeb l o

Antidiabetic agents (sulfonylureas)

Potential for increased hypoglycemic effectb l o

Aspirin

Increased risk of salicylate toxicityl

Avoid concomitant usel

Corticosteroids

Decreased plasma salicylate concentrationsb

Potential increased plasma salicylate concentrations and salicylate toxicity when corticosteroids are discontinuedb l o

Diuretics

Increased plasma salicylate concentrationsl o

Methotrexate

Possible increased methotrexate toxicity because of displacement from protein binding sitesb l o

Pyrazinamide

Possible prevention or reduction of hyperuricemia associated with pyrazinamideb l o

Sulfur

Possible synergistic keratolytic effecta

Uricosuric agents (probenecid, sulfinpyrazone)

Reduced uricosuric effect of uricosuric agentsb l o

Salicylic Acid Pharmacokinetics Absorption Bioavailability

Rapidly and well absorbed percutaneously following topical application.b l

Following topical application of salicylic acid 6% gel, >60% absorbed, with peak plasma concentration usually attained within 5 hours (under occlusion).l o

Onset

In vitro, plaster (Trans-Ver-Sal) released about 16, 48, 65, 79, 89, and 100% of the salicylic acid dose by 0.5, 1, 2, 4, 8, and 24 hours, respectively.a

Plasma Concentrations

Following topical application of salicylic acid 6% gel, peak serum salicylate concentrations were <50 mcg/mL; concentrations >300 mcg/mL generally associated with salicylate toxicity.l o

Distribution Extent

Distributed in extracellular space.l o

Plasma Protein Binding

50–80%.l o

Special Populations

Patients with a contracted extracellular space secondary to dehydration or diuretics may have increased plasma salicylate levels.l o

Elimination Elimination Route

Excreted principally in urine as salicyluric acid (52%), salicylate glucuronides (42%), and free salicylic acid (6%).l o

Stability Storage Topical Cream, Lotion

20–25°C.l Do not freeze.l

Store combination lotion (salicylic acid 1% and sodium thiosulfate 25%) at 15–30°C.g

Solution

Solution in flexible collodion: Tightly closed containers at 15–30°C.a Flammable; keep away from heat and open flame.a d e

Gel

Tightly closed containers at 15–30°C.a p

Gel in flexible collodion: Tightly closed containers at 15–30°C.a Flammable, keep away from heat and open flame.a d e

Shampoo

Salicylic acid 3%: Tightly closed containers; avoid excessive heat or cold.m

Plaster

Well-closed containers at 15–30°C.a

ActionsActions

Exact mechanism(s) of action not elucidated; appears to soften and destroy the stratum corneum by increasing endogenous hydration that causes the cornified epithelium (horny layer) of the skin to swell, soften, and desquamate.a j l o

In low concentrations, has keratoplastic activity (correction of abnormal keratinization); at concentrations ?1%, has keratolytic activity (causes peeling of skin); and at concentrations ?20%, has a caustic effect.a

Has weak antifungal and antibacterial activity.a

May promote the penetration of other active ingredients and have a comedolytic effect.a

Requires moisture to exert its action on the skin and for maceration and desquamation of epidermal tissue.a

Advice to Patients

Importance of keeping salicylic acid preparations out of reach of children.g m o

Importance of avoiding heat or flames during use of certain salicylic acid collodion formulations.n o

For external use only.o Importance of avoiding contact with eyes.k n q r

Importance of rinsing hands thoroughly after topical application, unless hands are being treated.l o p

Advise patients that salicylic acid topical preparations used concurrently with other topical medications may increase skin dryness or irritation.c

Importance of not using for prolonged periods of time for self-medication of dandruff, seborrheic dermatitis, or psoriasis; importance of consulting a clinician if the condition worsens or does not improve after regular use.f

Advise patients that, when salicylic acid preparations are used for wart removal, visible improvement generally occurs during the first several days of treatment and complete removal may require 3–12 weeks of use.j

Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.l o p

Importance of patients informing clinician of existing or contemplated concomitant therapy, including prescription and OTC drugs.l o

Importance of informing patients of other important precautionary information. (See Cautions.) o

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Salicylic Acid

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Bulk

Powder*

Topical

Cake

0.5%

Aveeno Clear Complexion Cleansing Bar

Johnson & Johnson

Oxy Bar Soap

Mentholatum

2%

Salicylic Acid Cleansing Bar

Stiefel

Cleansing Cream

2%

Clearasil Oil Control Cream Cleanser

Reckitt Benckiser

Clearasil StayClear Skin Perfecting Wash

Reckitt Benckiser

Cleansing Pledgets (saturated with solution)

0.5%

Oxy Daily Cleansing Pad (with alcohol 34%)

Mentholatum

Stridex Sensitive Skin Pads (with SD alcohol 28% and aloe)

Blistex

1%

Stridex Essential Care Pads

Blistex

2%

Clearasil StayClear Acne Fighting Cleansing Wipes

Reckitt Benckiser

Clearasil StayClear Daily Pore Cleansing Pads

Reckitt Benckiser

Clearasil Ultra Deep Pore Cleansing Pads (with propylene glycol and parabens)

Reckitt Benckiser

Noxzema Triple Clean Pads (with SD-alcohol 40)

Procter & Gamble

Oxy Blackhead Pads (with alcohol 46%)

Mentholatum

Oxy Daily Cleansing Pads (with alcohol 46%)

Mentholatum

Oxy Maximum Cleansing Pads (with alcohol 46%)

Mentholatum

Stridex Pads Maximum Strength (with SD alcohol 40 44%)

Blistex

Cleansing Solution

2%

Noxzema Triple Clean Blackhead Cleanser

Proctor & Gamble

Oxy Body Wash (with parabens and propylene glycol)

Mentholatum

Oxy Face Wash

Mentholatum

Cleansing Suspension

2%

Clearasil StayClear Daily Facial Scrub

Reckitt Benckiser

Oxy Maximum Face Scrub (with parabens and propylene glycol)

Mentholatum

Cream

6%

Salex (with parabens)

Coria

Gel

1%

Clearasil Blackhead Control

Reckitt Benckiser

2%

Neutrogena Rapid Clear Acne Eliminating (with propylene glycol)

Neutrogena

Stridex Clear Gel Maximum Strength (with SD alcohol 9.3%)

Blistex

3%

Dermarest Psoriasis Medicated Scalp Treatment (with SD alcohol 40, propylene glycol, and parabens)

Del

Dermarest Psoriasis Medicated Skin Treatment (with parabens and propylene glycol)

Del

Keralyt (with SD-40 alcohol 21% and propylene glycol)

Summers

6%

Hydrisalic (with SD alcohol 40B and propylene glycol)

Pedinol

Keralyt (with SD-40 alcohol 21% and propylene glycol)

Summers

17%

Sal-Plant Gel (with isopropyl alcohol 2.5% in flexible collodion)

Pedinol

17.6%

Compound W Gel (with alcohol 67.5% in flexible collodion)

Prestige

Lotion

2%

Dermarest Psoriasis Medication Moisturizer (with parabens)

Del

Sebasorb (with attapulgite activated, acetyl alcohol, and propylene glycol)

Summers

6%

Salex (with parabens)

Coria

Ointment

3%

MG 217 Sal-Acid

Triton

Plaster

15%

Trans-Ver-Sal (with karaya and propylene glycol)

Doak

40%

Compound W One Step Invisible Strips

Prestige

Compound W One Step Pads

Prestige

Curad Mediplast

Beiersdorf

Dr Scholl’s Callus Remover

Schering-Plough

Dr Scholl’s Clear Away Medicated Disk

Schering-Plough

Dr Scholl’s Clear Away One-Step Invisible Strips

Schering-Plough

Dr Scholl’s Clear Away Plantar for Feet

Schering-Plough

Sal-Acid

Pedinol

Shampoo

2%

Ionil Plus (with SD alcohol 40 12%)

Healthpoint

P&S (with methylparaben and propylparaben)

Aero

3%

Denorex Extra Strength Shampoo (with propylene glycol)

Prestige

DHS Sal Shampoo

Person & Covey

Neutrogena T/Sal Maximum Strength

Neutrogena

Psoriasin Therapeutic Shampoo & Body Wash

Alva-Amco Pharmacal

Solution

2%

Noxzema 2-in-1 Astringent (with SD-alcohol 40)

Procter & Gamble

Noxzema Continuous Clean Clarifying Toner

Procter & Gamble

3%

Dermarest Psoriasis Medicated Overnight Treatment

Del

16.7%

Gordofilm (in flexible collodion)

Gordon

17%

Dr Scholl’s Clear Away Fast Acting Liquid (with SD alcohol 32 17% and ether 52% in flexible collodion)

Schering-Plough

Dr Scholl’s Liquid Corn/Callus Remover (with alcohol SD 32 18% and ether 53% in flexible collodion)

Schering-Plough

DuoFilm (with alcohol SD 32 17% and ether 52% in flexible collodion)

Schering-Plough

Occlusal-HP (with isopropyl alcohol 63% in polyacrylic vehicle)

Bioglan

Salactic Film (with isopropyl alcohol 2.7% in flexible collodion)

Pedinol

Wart-Off (with alcohol 26.35% in flexible collodion)

Pfizer

17.6%

Compound W Liquid (with alcohol 21.2% and ether 63.6% in flexible collodion)

Prestige

Freezone (with alcohol 33% and ether 65.5% in flexible collodion)

Prestige

Salicylic Acid Combinations

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Topical

Lotion

1% with Sodium Thiosulfate 25%

Versiclear (with propylene glycol)

Hope

Ointment

5% with Urea 10%

Kerasal Foot Ointment

Alterna

Shampoo

3% with Coal Tar Solution 10% (equivalent to 2% coal tar)

Tarsum

Summers

3% with Colloidal Sulfur 5%

Meted

DUSA

Comparative Pricin
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Vaniqa Cream


Pronunciation: eh-FLOOR-neh-theen
Generic Name: Eflornithine
Brand Name: Vaniqa
Vaniqa Cream is used for:

Slowing the growth of unwanted facial hair in women.

Vaniqa Cream is an enzyme inhibitor. It works by blocking an enzyme necessary for hair to grow.

Do NOT use Vaniqa Cream if: you are allergic to any ingredient in Vaniqa Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Vaniqa Cream:

Some medical conditions may interact with Vaniqa Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have scraped or broken skin, or sores on the affected area

Some MEDICINES MAY INTERACT with Vaniqa Cream. However, no specific interactions with Vaniqa Cream are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vaniqa Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Vaniqa Cream:

Use Vaniqa Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

Vaniqa Cream comes with an additional patient leaflet. Read it carefully and reread it each time you get Vaniqa Cream refilled. Ask your doctor or pharmacist any questions that you may have about Vaniqa Cream. Apply a thin layer of Vaniqa Cream to the affected areas of the face and under the chin, at least 5 minutes after hair removal (eg, plucking, shaving). Rub in thoroughly. Do not wash the treated area for at least 4 hours. Wait at least 8 hours between applications of Vaniqa Cream. Cosmetics or sunscreens may be applied to treated areas after Vaniqa Cream has dried. If you miss a dose of Vaniqa Cream, skip the missed dose and return to your regular dosing schedule. Do not apply 2 doses at once.

Ask your health care provider any questions you may have about how to use Vaniqa Cream.

Important safety information: Vaniqa Cream is for external use only. Avoid contact with the vaginal area, eyes, nose, or mouth. Vaniqa Cream does not remove hair. You will need to continue your routine method of hair removal while using Vaniqa Cream. You may need to use Vaniqa Cream for at least 4 to 8 weeks before you begin to see improvement. If your symptoms do not improve or become worse, contact your doctor. Use Vaniqa Cream with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Vaniqa Cream during pregnancy. It is unknown if Vaniqa Cream is excreted in breast milk. If you are or will be breast-feeding while you are using Vaniqa Cream, check with your doctor or pharmacist to discuss the risks to your baby. Possible side effects of Vaniqa Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness; skin tingling; temporary stinging or burning.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding or irritation of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Vaniqa side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Vaniqa Cream may be harmful if swallowed. Symptoms may include dizziness; facial swelling; hair loss; headache; hearing loss; loss of appetite; seizures; unusual bruising or bleeding; upset stomach; weakness.

Proper storage of Vaniqa Cream:

Store Vaniqa Cream at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vaniqa Cream out of the reach of children and away from pets.

General information: If you have any questions about Vaniqa Cream, please talk with your doctor, pharmacist, or other health care provider. Vaniqa Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Vaniqa Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Vaniqa resources Vaniqa Side Effects (in more detail) Vaniqa Use in Pregnancy & Breastfeeding Vaniqa Support Group 8 Reviews for Vaniqa - Add your own review/rating Compare Vaniqa with other medications Hirsutism
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Tretin-X Gel


Pronunciation: TRET-i-noin
Generic Name: Tretinoin
Brand Name: Tretin-X
Tretin-X Gel is used for:

Treating acne. It may also be used for other conditions as determined by your doctor.

Tretin-X Gel is a kit that contains tretinoin gel, a cleanser, and a moisturizer. The tretinoin gel works in the skin to reduce the formation of acne and to help acne heal more quickly. The cleanser helps to keep the skin clean, and the moisturizer helps to soothe skin and keep it soft.

Do NOT use Tretin-X Gel if: you are allergic to any ingredient in Tretin-X Gel

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tretin-X Gel:

Some medical conditions may interact with Tretin-X Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have eczema, an abnormally high white blood cell count, diabetes, or a sunburn

Some MEDICINES MAY INTERACT with Tretin-X Gel. Tell your health care provider if you are using any other medicines, especially any of the following:

Topical medicines containing alcohol, resorcinol, sulfur, or salicylic acid because the risk of excessive skin dryness or irritation may occur

Ask your health care provider if Tretin-X Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tretin-X Gel:

Use Tretin-X Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tretin-X Gel is for external use only. In the morning, use the foaming cleanser provided in this kit to gently wash your face. Use warm water, and do not scrub. Gently pat your face dry. If your skin feels dry or rough, apply a thin layer of the moisturizer provided in this kit to your face and neck. If you are going to be outside, apply a sunscreen with an SPF of 15 or higher to your face. At bedtime, gently wash your face again with the foaming cleanser provided in this kit. Gently pat your face dry. Wait 30 minutes for skin to dry completely. Apply the gel in this kit to areas of your skin with acne, or as directed by your doctor. Then, gently apply a thin layer of the moisturizer provided in this kit to your entire face and neck. Wash your hands immediately after using Tretin-X Gel. If you miss a dose of Tretin-X Gel, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Tretin-X Gel.

Important safety information: Avoid getting Tretin-X Gel in your eyes, nose, or mouth. If you get Tretin-X Gel in your eyes, rinse thoroughly with water. Tretin-X Gel may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tretin-X Gel. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using Tretin-X Gel at this time. Talk with your doctor before you use any other medicines or products on your skin. While you are using Tretin-X Gel, you may use cosmetics. Do not apply Tretin-X Gel to skin that is sunburned. Wait until the burn is fully healed before using Tretin-X Gel. Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor. Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using Tretin-X Gel. Do not use Tretin-X Gel for any condition other than that for which it was prescribed. Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Tretin-X Gel. Tretin-X Gel may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away. Tretin-X Gel is flammable. Do not store or use near an open flame. Tretin-X Gel should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tretin-X Gel while you are pregnant. It is not known if Tretin-X Gel is found in breast milk after topical use. If you are or will be breast-feeding while you use Tretin-X Gel, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Tretin-X Gel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Increase or decrease of skin pigment (color); redness or peeling at the application site; sensitivity to sunlight; skin irritation; warmth or stinging at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe redness, peeling, swelling, blistering, or crusting of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tretin-X side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; dizziness; excessive redness, peeling, and discomfort; flushing; headache; stomach pain.

Proper storage of Tretin-X Gel:

Store Tretin-X Gel at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store in a tightly closed container. Store away from heat and light. Do not store in the bathroom. Keep Tretin-X Gel out of the reach of children and away from pets.

General information: If you have any questions about Tretin-X Gel, please talk with your doctor, pharmacist, or other health care provider. Tretin-X Gel is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tretin-X Gel. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Tretin-X resources Tretin-X Side Effects (in more detail)Tretin-X Use in Pregnancy & BreastfeedingTretin-X Drug InteractionsTretin-X Support Group1 Review for Tretin-X - Add your own review/rating Compare Tretin-X with other medications AcneLichen SclerosusNecrobiosis Lipoidica DiabeticorumPhotoaging of the Skin
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Venofer IV Iron Sucrose


Vifor (International) Inc.

VENOFER 20 mg/ml injection

[Iron sucrose (iron (III) hydroxide sucrose complex)]

Please read this leaflet carefully. It contains a summary of the information available on Venofer 20 mg/ml injection which is part of your hospital treatment. If after reading this you have any questions ask the doctor or nurse.

In this leaflet 1. What Venofer is and what it is used for. 2. Before you receive Venofer. 3. How Venofer is administered. 4. Possible side effects of Venofer. 5. Storing Venofer. What Venofer is and what it is used for

Venofer is a sterile, dark brown, non transparent, aqueous solution of iron intended to be used only for intravenous injection or as a concentrate for solution for infusion which contains the active ingredient iron as a solution of iron sucrose (iron(III)-hydroxide sucrose complex). The solution also contains sodium hydroxide and water for injection.

Venofer is supplied in glass ampoules which contain 5ml of solution which is equivalent to 100mg of iron. The product is supplied in cardboard boxes each containing 5 ampoules.

Marketing authorisation holder: Vifor France SA 123, rue Jules Guesde 92300 Levallois-Perret France Manufacturer: ALTANA Pharma AG Byk-Gulden-Str. 2 D-78467 Konstanz Germany

Venofer provides a source of iron that can help to replenish a shortage of iron in patients with iron deficiency.

The product is intended for use only in the following circumstances:

in a patient known to be intolerant to iron preparations taken by mouth, in a patient where there is a specific clinical need to deliver iron rapidly to the iron stores, in a patient with active inflammatory bowel disease where iron preparations taken by mouth are ineffective or not tolerated. Before you receive Venofer You should be aware that: a blood test should have been carried out to ensure treatment with this medicine is appropriate, the product should not be given at the same time as other iron preparations taken by mouth, Venofer should not be administered during the first three months of pregnancy and it should be administered with caution during the fourth to ninth month. intramuscular or intravenous iron preparations can cause severe allergic or anaphylactoid reactions which may be potentially fatal. Therefore the medicine should only be given if there are appropriate medical facilities immediately available, allergic reactions, sometimes involving joint pain, have been more commonly observed when the recommended dose is exceeded. the product is not approved for use in children. You should not receive Venofer if: you are known to be sensitive (allergic) to any iron preparations intended for intramuscular or intravenous administration, you have a history of asthma, eczema or other atopic allergies because then you are more susceptible to experience allergic reactions, your anaemia is not due to a shortage of iron, you have a history of cirrhosis or hepatitis or have increased liver enzymes, you have any acute or chronic infections because these may be worsened by giving intramuscular or intravenous iron. How Venofer is administered

Venofer should only be administered by the intravenous route by slow intravenous injection or by intravenous drip infusion which is the preferred route. The product must not be administered by intramuscular or subcutaneous injection. For intravenous infusion the 5ml ampoule (100mg iron) should be diluted in 0.9% saline. No other intravenous dilution solutions or therapeutic agents should be used.

Before receiving your first dose, you should receive a small "test dose" which may help reduce the chance of a serious reaction occurring.

The total dose of Venofer you require is given in single doses of one ampoule not more than three times per week. This may be increased to two ampoules not more than three times per week depending on the severity of your iron deficiency. Your doctor will take responsibility for calculating the appropriate dose and frequency of injections.

Possible side effects of Venofer

The most commonly reported side effects of Venofer are temporary changes in taste, low blood pressure, fever, shivering, injection site reactions and nausea. Non-serious allergic reactions occurred rarely. In general, allergic reactions are potentially the most serious side effects. In these reactions, very rarely symptoms of low blood pressure, facial swelling and difficulty in breathing can be involved. See ‘Before you receive Venofer’ section 2.

The following possible side effects have been reported following the administration of Venofer:

Nervous system disorders

Common (greater than or equal to 1% and less than 10%): temporary changes in taste (in particular metallic taste).

Uncommon (greater than or equal to 0.1% and less than 1%) : headache; dizziness.

Rare (greater than or equal to 0.01% and less than 0.1%): tingling, “pins and needles”

Isolated cases: decreased alertness, light-headed feeling, confusion.

Heart and blood vessel disorders

Uncommon: low blood pressure and collapse; rapid heart beat, palpitations.

Lungs and airways disorders

Uncommon: wheezing, difficulty in breathing.

Stomach and intestine disorders

Uncommon: nausea; vomiting; abdominal (e.g. stomach) pain; diarrhoea.

Skin disorders

Uncommon: itching; hives; rash, redness.

Muscle, bone and joint disorders

Uncommon: muscle cramps, muscle pain.

Isolated cases: swelling of joints.

General disorders and administration site disorders

Uncommon: fever, shivering, flushing; chest pain and chest tightness. Burning, swelling and similar reactions (sometimes involving veins) around the site of injection.

Rare: allergic reactions (rarely involving joint pain); swelling of hands and feet; tiredness, weakness; general feeling of illness.

Isolated cases: face and tongue swelling.

Storing Venofer

Venofer is to be kept out of the reach and sight of children.

The product should not be used after the expiry date printed on the label. The ampoules should be stored below 25°C in the original cartons. The product should not be frozen. Once the ampoules have been opened they should be used immediately. After dilution with 0.9% saline the solution should be used immediately or within 3 hours if stored at room temperature.

Further information

This leaflet does not tell you everything about Venofer. If you have any questions or are not sure about receiving treatment with this medicine, then ask your doctor. Please keep this leaflet until your course of treatment with Venofer has been completed.

This Leaflet was approved:

United Kingdom: December 2003


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Tretin-X Cream


Pronunciation: TRET-i-noin
Generic Name: Tretinoin
Brand Name: Tretin-X
Tretin-X Cream is used for:

Treating acne. It may also be used for other conditions as determined by your doctor.

Tretin-X Cream is a kit that contains tretinoin cream, a cleanser, and a moisturizer. The tretinoin cream works in the skin to reduce the formation of acne and to help acne heal more quickly. The cleanser helps to keep the skin clean, and the moisturizer helps to soothe skin and keep it soft.

Do NOT use Tretin-X Cream if: you are allergic to any ingredient in Tretin-X Cream

Contact your doctor or health care provider right away if this applies to you.

Before using Tretin-X Cream:

Some medical conditions may interact with Tretin-X Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have eczema, an abnormally high white blood cell count, diabetes, or a sunburn

Some MEDICINES MAY INTERACT with Tretin-X Cream. Tell your health care provider if you are using any other medicines, especially any of the following:

Topical medicines containing alcohol, resorcinol, sulfur, or salicylic acid because the risk of excessive skin dryness or irritation may occur

Ask your health care provider if Tretin-X Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tretin-X Cream:

Use Tretin-X Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tretin-X Cream is for external use only. In the morning, use the foaming cleanser provided in this kit to gently wash your face. Use warm water, and do not scrub. Gently pat your face dry. If your skin feels dry or rough, apply a thin layer of the moisturizer provided in this kit to your face and neck. If you are going to be outside, apply a sunscreen with an SPF of 15 or higher to your face. At bedtime, gently wash your face again with the foaming cleanser provided in this kit. Gently pat your face dry. Wait 30 minutes for skin to dry completely. Apply the cream in this kit to areas of your skin with acne, or as directed by your doctor. Then, gently apply a thin layer of the moisturizer provided in this kit to your entire face and neck. Wash your hands immediately after using Tretin-X Cream. If you miss a dose of Tretin-X Cream, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Tretin-X Cream.

Important safety information: Tretin-X Cream is for external use only. Avoid getting Tretin-X Cream in your eyes, nose, or mouth. If you get Tretin-X Cream in your eyes, rinse thoroughly with water. Tretin-X Cream may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Tretin-X Cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using Tretin-X Cream at this time. Talk with your doctor before you use any other medicines or products on your skin. While you are using Tretin-X Cream, you may use cosmetics. Do not apply Tretin-X Cream to skin that is sunburned. Wait until the burn is fully healed before using Tretin-X Cream. Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor. Avoid using other topical medication, cosmetics, or other products that have a strong drying effect. If you have dry skin from using these products, allow your skin to "rest" before using Tretin-X Cream. Do not use Tretin-X Cream for any condition other than that for which it was prescribed. Weather extremes, such as windy or cold weather, may irritate your skin more while you are using Tretin-X Cream. Tretin-X Cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away. Tretin-X Cream should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tretin-X Cream while you are pregnant. It is not known if Tretin-X Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Tretin-X Cream, check with your doctor. Discuss any possible risks to your baby. Possible side effects of Tretin-X Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Increase or decrease of skin pigment (color); redness, peeling, or feeling of warmth; sensitivity to sunlight; skin irritation; stinging at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe redness, swelling, blistering, or crusting of the skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tretin-X side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include clumsiness; dizziness; excessive redness, peeling, and discomfort; flushing; headache; stomach pain. Tretin-X Cream may be harmful if swallowed.

Proper storage of Tretin-X Cream:

Store Tretin-X Cream at room temperature, between 59 and 80 degrees F (15 and 26 degrees C). Store in a tightly closed container. Store away from heat and light. Keep Tretin-X Cream out of the reach of children and away from pets.

General information: If you have any questions about Tretin-X Cream, please talk with your doctor, pharmacist, or other health care provider. Tretin-X Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tretin-X Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More Tretin-X resources Tretin-X Side Effects (in more detail) Tretin-X Use in Pregnancy & Breastfeeding Tretin-X Drug Interactions Tretin-X Support Group 1 Review for Tretin-X - Add your own review/rating Compare Tretin-X with other medications Acne Lichen Sclerosus Necrobiosis Lipoidica Diabeticorum Photoaging of the Skin
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Creon


1. Name Of The Medicinal Product

Creon® 10000 Capsules

Creon® 25000 Capsules

Creon® 40000 Capsules

2. Qualitative And Quantitative Composition

Creon 10000

Each capsule contains pancreatin 150 mg equivalent to:

Lipase 10,000 PhEur units

Amylase 8,000 PhEur units

Protease 600 PhEur units

Creon25000

Each capsule contains pancreatin PhEur 300 mg equivalent to:

Lipase 25,000 PhEur units

Amylase 18,000 PhEur units

Protease 1,000 PhEur units

Creon40000

Each capsule contains pancreatin PhEur 400 mg equivalent to:

Lipase 40,000 PhEur units

Amylase 25,000 PhEur units

Protease 1,600 PhEur units

3. Pharmaceutical Form

Creon 10000

Brown/clear capsules containing gastro-resistant granules.

Creon25000

Orange/colourless capsules filled with brownish minimicrospheres.

Creon 40000

Brown/clear size 00 capsules containing light brown, gastro-resistant granules.

4. Clinical Particulars 4.1 Therapeutic Indications

For the treatment of pancreatic exocrine insufficiency.

4.2 Posology And Method Of Administration

Adults (including the elderly) and children:

Creon 40000 should only be used if the patient requires equal to or more than 40,000 lipase units per meal or snack. Creon 40000 should only be used in patients in whom the minimum effective dose has already been determined using lower strength pancreatic enzyme products.

Initially one or two capsules with meals. Dose increases, if required, should be added slowly, with careful monitoring of response and symptomatology.

Creon 10000 and 25000

The capsules can be swallowed whole, or for ease of administration they may be opened and the granules taken with fluid or soft food. If the granules are mixed with food, it is important that they are taken immediately, otherwise dissolution of the enteric coating may result. In order to protect the enteric coating, it is important that the granules are not crushed or chewed.

Creon 40000 only

The capsules should be swallowed whole.

It is important to ensure adequate hydration of patients at all times whilst dosing Creon .

Colonic damage has been reported in patients with cystic fibrosis taking in excess of 10,000 units of lipase/kg/day (see Undesirable Effects).

4.3 Contraindications

Patients with known hypersensitivity to porcine proteins.

4.4 Special Warnings And Precautions For Use

The product is of porcine origin.

Oral medications should not be administered during the early stages of acute pancreatitis.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

None known.

4.6 Pregnancy And Lactation

There is inadequate evidence of safety in use during pregnancy and lactation. However, as enzymes are not absorbed, it is unlikely that there would be any effect on the nursing infant.

4.7 Effects On Ability To Drive And Use Machines

Creon has no influence on the ability to drive or use machines.

4.8 Undesirable Effects

Diarrhoea, constipation, gastric discomfort, nausea and skin reactions have been reported occasionally in patients receiving enzyme replacement therapy.

Rarely cases of hyper-uricosuria and hyper-uricaemia have been reported with very high doses of pancreatin.

Stricture of the ileo-caecum and large bowel and colitis has been reported in children with cystic fibrosis taking high doses of pancreatic enzyme supplements. To date, Creon 10000 and 25000 have not been implicated in the development of colonic damage. Experience with Creon 40000 in clinical use is limited. However, unusual abdominal symptoms or changes in abdominal symptoms should be reviewed to exclude the possibility of colonic damage - especially if the patient is taking in excess of 10,000 units of lipase/kg/day.

4.9 Overdose

Most cases respond to supportive measures including stopping enzyme therapy, ensuring adequate rehydration.

5. Pharmacological Properties 5.1 Pharmacodynamic Properties

The ATC code is A09A A (Enzyme preparations).

Replacement therapy in pancreatic enzyme deficiency states. The enzymes have hydrolytic activity on fat, carbohydrates and proteins.

5.2 Pharmacokinetic Properties

Pharmacokinetic data are not available as the enzymes act locally in the gastro-intestinal tract. After exerting their action, the enzymes are digested themselves in the intestine.

5.3 Preclinical Safety Data

None stated.

6. Pharmaceutical Particulars 6.1 List Of Excipients

Granules: Macrogol 4000, liquid paraffin, hypromellose phthalate, dibutyl phthalate, dimeticone.

Capsule shell: Gelatin, iron oxide (E172), titanium dioxide (E171).

6.2 Incompatibilities None known. 6.3 Shelf Life

Creon 10000 and 25000:

2 years

Creon 40000: 3

years

6.4 Special Precautions For Storage

Creon 10000:

Do not store above 30°C

Creon 25000:

Store below 25°C.

Creon 40000:

Do not store above 25°C. Keep container tightly closed.

6.5 Nature And Contents Of Container

Creon 10000, 25000 and 40000: HDPE tablet container with LDPE closure. Each container contains 100 capsules.

6.6 Special Precautions For Disposal And Other Handling

6.5

No special instructions.

Administrative Data 7. Marketing Authorisation Holder Solvay Healthcare Limited

Mansbridge Road

West End

Southampton

SO18 3JD

United Kingdom

8. Marketing Authorisation Number(S)

Creon 10000:

PL 00512/0149

Creon 25000:

PL 00512/0150

Creon 40000:

PL 00512/0177

9. Date Of First Authorisation/Renewal Of The Authorisation

Creon 10000 and 25000:

1 January 2001

Creon 40000:

5 July 2002

10. Date Of Revision Of The Text

Creon 10000: May 2002

Creon 25000: June 2003

Creon 40000: October 2002

Legal Category

Creon 10000: P

Creon 25000 and 40000: POM


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Maalox Plus Suspension


Maalox plus

Contents:

500 ml Suspension

Contains the equivalent of Dried Aluminium Hydroxide Gel 220 mg, Magnesium Hydroxide 195 mg and Simeticone 25 mg in each 5 ml.

Also contains: methylparaben, propylparaben, micro-crystalline cellulose, sodium carboxymethylcellulose, methylcellulose, hydroxypropylcellulose, hydrogen peroxide, citric acid, sodium saccharin, sorbitol, natural lemon concentrate, swiss creme flavour and water.

Maalox Plus is an antacid which relieves symptoms by neutralising stomach acid and has an antifoaming agent which aids removal of gas.

MA Holder: sanofi-aventis One Onslow Street Guildford Surrey GU1 4YS UK Manufactured by sanofi-aventis S.p.A. Viale Europa 11 - Origgio (VA) Italy For:

symptomatic relief of dyspepsia (indigestion), heartburn and flatulence (wind).

Do not take if you are allergic to any of the active and other ingredients, you are feeling severely debilitated or suffer from kidney disease or hypophosphataemia.

Ask your Pharmacist or Doctor before taking Maalox Plus if you are taking any other medicines or you are pregnant or breast feeding.

Maalox Plus should not be taken at the same time as other medicines, as Maalox Plus may interfere with the absorption if taken within one hour.

Directions:

adults including elderly persons: take one to two 5 ml spoonfuls 20 minutes to 1 hour after meals and at bedtime or as required.

Children: an appropriate proportion of the adult dose.

Children under 5 years old: not more than one 5ml spoonful three times a day.

If symptoms persist consult your doctor.

Contact your doctor immediately if too much is taken.

SHAKE WELL BEFORE USE.

Side Effects:

constipation or diarrhoea can occur but these effects are not common.

Tell your doctor or pharmacist if you notice any other unwanted effects.

Use by the date given on the label below.

Do not allow this product to freeze.

Remember to keep all medicines safely away from children.

Information revised: January 2007

PL5272/0020


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