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Hyperlipoproteinemia Medications


Drugs associated with Hyperlipoproteinemia

The following drugs and medications are in some way related to, or used in the treatment of Hyperlipoproteinemia. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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Topics under Hyperlipoproteinemia Hyperlipoproteinemia Type IIa, Elevated LDL (27 drugs) Hyperlipoproteinemia Type IIb, Elevated LDL VLDL (26 drugs) Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL (5 drugs) Hyperlipoproteinemia Type IV, Elevated VLDL (20 drugs) Hyperlipoproteinemia Type V, Elevated Chylomicrons VLDL (15 drugs)
Drug List: Advicor Altocor Altoprev-Extended-Release-Tablets Antara Atromid-S B-3-50-Nicotinic-Acid B3-500-Gr-Nicotinic-Acid Cholestyramine-Light Colestid Colestid-Flavored Crestor Fenoglide Lescol Lescol-Xl-Extended-Release-Tablets Lipitor Lipofen Locholest Locholest-Light Lofibra Lopid Mevacor Niacin-Sr-Nicotinic-Acid Niacor Niaspan Nicotinex Pravachol Prevalite-Powder Questran-Powder Questran-Light Simcor Slo-Niacin-Controlled-Release-Capsules Tricor Triglide Welchol Zocor
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High Cholesterol Medications


Definition of High Cholesterol: Acquired lipid disorders is a group of disorders characterized by an excess of fatty substances, such as cholesterol, triglycerides, and lipoproteins present in the blood.

Drugs associated with High Cholesterol

The following drugs and medications are in some way related to, or used in the treatment of High Cholesterol. This service should be used as a supplement to, and NOT a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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Topics under High Cholesterol High Cholesterol, Familial Heterozygous (14 drugs) High Cholesterol, Familial Homozygous (6 drugs) Hyperlipoproteinemia (128 drugs in 6 topics) Hypertriglyceridemia (30 drugs) Niacin Flush (34 drugs) Sitosterolemia (1 drug) Learn more about High Cholesterol

Medical Encyclopedia:

Familial hypercholesterolemia High blood cholesterol levels

Harvard Health Guide:

Symptoms and treatment for High Cholesterol (Hypercholesterolemia)

Drugs.com Health Center:

Cholesterol Center
Drug List: Advicor Altocor Altoprev-Extended-Release-Tablets Atromid-S B-3-50-Nicotinic-Acid B3-500-Gr-Nicotinic-Acid Baycol Choloxin Crestor Evening-Primrose-Oil Fibricor Juvisync Lescol Lescol-Xl-Extended-Release-Tablets Lipitor Livalo Lopid Mevacor Niacin-Sr-Nicotinic-Acid Niacor Niaspan Nicotinex Pravachol Pravigard_Pac Primrose-Oil Simcor Slo-Niacin-Controlled-Release-Capsules Trilipix Vytorin Welchol Zetia Zocor
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Estrogen receptor antagonists


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Estrogen receptor antagonists bind to estrogen receptors and inhibit the action of estrogen. Estrogen controls the growth of certain types of breast cancers called estrogen receptor positive cancers. So estrogen receptor antagonists are useful in treating patients with estrogen sensitive breast cancers.

See also

Medical conditions associated with estrogen receptor antagonists:

Breast CancerBreast Cancer, Metastatic Drug List:Faslodex
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Welchol



Dosage Form: tablet, film coated, oral suspension
FULL PRESCRIBING INFORMATION Indications and Usage for Welchol Primary Hyperlipidemia

Welchol is indicated as an adjunct to diet and exercise to reduce elevated low-density lipoprotein cholesterol (LDL-C) in adults with primary hyperlipidemia (Fredrickson Type IIa) as monotherapy or in combination with an hydroxymethyl-glutaryl-coenzyme A (HMG CoA) reductase inhibitor (statin).

 Welchol is indicated as monotherapy or in combination with a statin to reduce LDL-C levels in boys and postmenarchal girls, 10 to 17 years of age, with heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy the following findings are present:
a. LDL-C remains ? 190 mg/dL or
b. LDL-C remains ? 160 mg/dL and

 there is a positive family history of premature cardiovascular disease or  two or more other CVD risk factors are present in the pediatric patient.

Lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol when response to diet and non-pharmacological interventions alone has been inadequate [See Clinical Studies (14.1)].

In patients with coronary heart disease (CHD) or CHD risk equivalents such as diabetes mellitus, LDL-C treatment goals are < 100 mg/dL. An LDL-C goal of < 70 mg/dL is a therapeutic option on the basis of recent trial evidence. If LDL-C is at goal but the serum triglyceride (TG) value is > 200 mg/dL, then non-HDL cholesterol (non-HDL-C) (total cholesterol [TC] minus high density lipoprotein cholesterol [HDL-C]) becomes a secondary target of therapy. The goal for non-HDL-C in persons with high serum TG is set at 30 mg/dL higher than that for LDL-C.

Type 2 Diabetes Mellitus

Welchol is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus [See Clinical Studies (14.2)].

Diabetes mellitus is considered a CHD risk equivalent. In addition to glycemic control, intensive lipid control is warranted [See Indications and Usage (1.1) and Warnings and Precautions (5.2)].

Important Limitations of Use Welchol should not be used for the treatment of type 1 diabetes or for the treatment of diabetic ketoacidosis. Welchol has not been studied in type 2 diabetes as monotherapy or in combination with a dipeptidyl peptidase 4 inhibitor and has not been extensively studied in combination with thiazolidinediones. Welchol has not been studied in Fredrickson Type I, III, IV, and V dyslipidemias.  Welchol has not been studied in children younger than 10 years of age or in pre-menarchal girls. Welchol Dosage and Administration Primary Hyperlipidemia

The recommended dose of Welchol Tablets in adults, whether used as monotherapy or in combination with a statin, is 6 tablets once daily or 3 tablets twice daily. Welchol Tablets should be taken with a meal and liquid.

 The recommended dose of Welchol for Oral Suspension, in adults and children 10 to 17 years of age, is one 3.75 gram packet once daily or one 1.875 gram packet twice daily. To prepare, empty the entire contents of one packet into a glass or cup. Add ? to 1 cup (4 to 8 ounces) of water, fruit juice, or diet soft drinks. Stir well and drink. Welchol for Oral Suspension should be taken with meals. To avoid esophageal distress, Welchol for Oral Suspension should not be taken in its dry form. Due to tablet size, it is recommended that any patient who has difficulty swallowing tablets use Welchol for Oral Suspension.

Welchol can be dosed at the same time as a statin or the two drugs can be dosed apart [See Clinical Studies (14.1)].

After initiation of Welchol, lipid levels should be analyzed within 4 to 6 weeks.

Type 2 Diabetes Mellitus

The recommended dose of Welchol Tablets is 6 tablets once daily or 3 tablets twice daily. Welchol should be taken with a meal and liquid.

 The recommended dose of Welchol for Oral Suspension is one 3.75 gram packet once daily or one 1.875 gram packet twice daily. To prepare, empty the entire contents of one packet into a glass or cup. Add ? to 1 cup (4 to 8 ounces) of water, fruit juice, or diet soft drinks. Stir well and drink. Welchol for Oral Suspension should be taken with meals. To avoid esophageal distress, Welchol for Oral Suspension should not be taken in its dry form.

Dosage Forms and Strengths Tablets: 625 mg tablets are off-white, oval, film-coated and imprinted with "Sankyo" and "C01" on one side. Oral Suspension: a white to pale yellow powder containing yellow granules packaged in single-dose packets: 3.75 gram single-dose packet, 1.875 gram single-dose packet. Contraindications

Welchol is contraindicated in patients with

A history of bowel obstruction [See Warnings and Precautions (5.4)] Serum TG concentrations >500 mg/dL [See Warnings and Precautions (5.2)] A history of hypertriglyceridemia-induced pancreatitis [See Warnings and Precautions (5.2)] Warnings and Precautions General

The effect of Welchol on cardiovascular morbidity and mortality has not been determined.

Serum Triglycerides (TG)

Welchol, like other bile acid sequestrants, can increase serum TG concentrations.

Welchol had small effects on serum TG (median increase 5% compared to placebo) in trials of patients with primary hyperlipidemia [See Adverse Reactions (6.1) and Clinical Studies (14.1)].

In clinical trials in patients with type 2 diabetes, greater increases in TG levels occurred when Welchol was used in combination with sulfonylureas (median increase 18% compared to placebo in combination with sulfonylureas) and when Welchol was used in combination with insulin (median increase 22% compared to placebo in combination with insulin) [See Adverse Reactions (6.1) and Clinical Studies (14.2)]. Hypertriglyceridemia of sufficient severity can cause acute pancreatitis. The long-term effect of hypertriglyceridemia on the risk of coronary artery disease is uncertain. In patients with type 2 diabetes, the effect of Welchol on LDL-C levels may be attenuated by Welchol’s effects on TG levels and a smaller reduction in non-HDL-C compared to the reduction in LDL-C. Caution should be exercised when treating patients with TG levels greater than 300 mg/dL. Because most patients in the Welchol clinical trials had baseline TG <300 mg/dL, it is unknown whether patients with more uncontrolled baseline hypertriglyceridemia would have greater increases in serum TG levels with Welchol. In addition, the use of Welchol is contraindicated in patients with TG levels >500 mg/dL [See Contraindications (4)]. Lipid parameters, including TG levels and non-HDL-C, should be obtained before starting Welchol and periodically thereafter. Welchol should be discontinued if TG levels exceed 500 mg/dL or if the patient develops hypertriglyceridemia-induced pancreatitis [See Adverse Reactions (6.1)].

Vitamin K or Fat-Soluble Vitamin Deficiencies Precautions

Bile acid sequestrants may decrease the absorption of fat-soluble vitamins A, D, E, and K. No specific clinical studies have been conducted to evaluate the effects of Welchol on the absorption of co-administered dietary or supplemental vitamin therapy. In non-clinical safety studies, rats administered colesevelam hydrochloride at doses greater than 30-fold the projected human clinical dose experienced hemorrhage from vitamin K deficiency. Patients on oral vitamin supplementation should take their vitamins at least 4 hours prior to Welchol. Caution should be exercised when treating patients with a susceptibility to deficiencies of vitamin K (e.g., patients on warfarin, patients with malabsorption syndromes) or other fat-soluble vitamins.

Gastrointestinal Disorders

 Because of its constipating effects, Welchol is not recommended in patients with gastroparesis, other gastrointestinal motility disorders, and in those who have had major gastrointestinal tract surgery and who may be at risk for bowel obstruction. Because of the tablet size, Welchol Tablets can cause dysphagia or esophageal obstruction and should be used with caution in patients with dysphagia or swallowing disorders. To avoid esophageal distress, Welchol for Oral Suspension should not be taken in its dry form. Always mix Welchol for Oral Suspension with water, fruit juice, or diet soft drinks before ingesting.

Drug Interactions

Welchol reduces gastrointestinal absorption of some drugs. Drugs with a known interaction with colesevelam should be administered at least 4 hours prior to Welchol. Drugs that have not been tested for interaction with colesevelam, especially those with a narrow therapeutic index, should also be administered at least 4 hours prior to Welchol. Alternatively, the physician should monitor drug levels of the co-administered drug [See Drug Interactions (7) and Clinical Pharmacology (12.3)].

Phenylketonurics

 Welchol for Oral Suspension contains 24 mg phenylalanine per 1.875 gram packet and 48 mg phenylalanine per 3.75 gram packet [See Description (11)].

Adverse Reactions Clinical Studies Experience

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in clinical studies of another drug and may not reflect the rates observed in practice.

In the lipid-lowering trials, 807 adult patients received at least one dose of Welchol (total exposure 199 patient-years). In the type 2 diabetes trials, 566 patients received at least one dose of Welchol (total exposure 209 patient-years).

In clinical trials for the reduction of LDL-C, 68% of patients receiving Welchol vs. 64% of patients receiving placebo reported an adverse reaction. In clinical trials of type 2 diabetes, 60% of patients receiving Welchol vs. 56% of patients receiving placebo reported an adverse reaction.

Primary Hyperlipidemia: In 7 double-blind, placebo-controlled, clinical trials, 807 patients with primary hyperlipidemia (age range 18-86 years, 50% women, 90% Caucasians, 7% Blacks, 2% Hispanics, 1% Asians) and elevated LDL-C were treated with Welchol 1.5 g/day to 4.5 g/day from 4 to 24 weeks.

Table 1 Placebo-Controlled Clinical Studies of Welchol for Primary Hyperlipidemia: Adverse Reactions Reported in ? 2% of Patients and More Commonly than in Patients Given Placebo, Regardless of Investigator Assessment of Causality Number of Patients (%) Welchol
N = 807 Placebo
N = 258 Constipation 89 (11.0) 18 (7.0) Dyspepsia 67 (8.3) 9 (3.5) Nausea 34 (4.2) 10 (3.9) Accidental injury 30 (3.7) 7 (2.7) Asthenia 29 (3.6) 5 (1.9) Pharyngitis 26 (3.2) 5 (1.9) Flu syndrome 26 (3.2) 8 (3.1) Rhinitis 26 (3.2) 8 (3.1) Myalgia 17 (2.1) 1 (0.4)

 Pediatric Patients 10 to 17 Years of Age: In an 8-week double-blind, placebo-controlled study boys and post menarchal girls, 10 to 17 years of age, with heterozygous familial hypercholesterolemia (heFH) (n=192), were treated with Welchol tablets (1.9-3.8 g, daily) or placebo tablets [See Clinical Studies (14.1)].

 Table 2 Placebo-Controlled Clinical Study of Welchol for Primary Hyperlipidemia in heFH Pediatric Patients: Adverse Reactions Reported in ?2% of Patients and More Commonly than in Patients Given Placebo, Regardless of Investigator Assessment of Causality    Number of Patients (%)      Welchol  Placebo    N = 129  N = 65  Nasopharyngitis  8 (6.2)  3 (4.6)  Headache  5 (3.9)  2 (3.1)  Fatigue  5 (3.9)  1 (1.5)  Creatine Phosphokinase Increase  3 (2.3)  0 (0.0)  Rhinitis  3 (2.3)  0 (0.0)  Vomiting  3 (2.3)  1 (1.5)

 The reported adverse reactions during the additional 18-week open-label treatment period with Welchol 3.8 g per day were similar to those during the double-blind period and included headache (7.6%), nasopharyngitis (5.4%), upper respiratory tract infection (4.9%), influenza (3.8%), and nausea (3.8%) [See Clinical Studies (14.1)].

Type 2 Diabetes Mellitus: The safety of Welchol in patients with type 2 diabetes mellitus was evaluated in 4 double-blind, 12-26 week, placebo-controlled clinical trials. These trials involved 1128 patients (566 patients on Welchol; 562 patients on placebo) with inadequate glycemic control on metformin, sulfonylurea, or insulin when these agents were used alone or in combination with other anti-diabetic agents. Upon completion of the pivotal trials, 492 patients entered a 52-week open-label uncontrolled extension study during which all patients received Welchol 3.8 g/day while continuing background treatment with metformin, sulfonylurea, or insulin alone or in combination with other anti-diabetic agents.

A total of 6.7% of Welchol-treated patients and 3.2% of placebo-treated patients were discontinued from the diabetes trials due to adverse reactions. This difference was driven mostly by gastrointestinal adverse reactions such as abdominal pain and constipation.

One patient in the pivotal trials discontinued due to body rash and mouth blistering that occurred after the first dose of Welchol, which may represent a hypersensitivity reaction to Welchol.

Table 3 Placebo-Controlled Clinical Studies of Welchol Add-on Combination Therapy with Metformin, Insulin, Sulfonylureas: Adverse Reactions Reported in ? 2% of Patients and More Commonly than in Patients Given Placebo, Regardless of Investigator Assessment of Causality Number of Patients (%) Welchol
N = 566 Placebo
N = 562 Constipation 49 (8.7) 11 (2.0) Nasopharyngitis 23 (4.1) 20 (3.6) Dyspepsia 22 (3.9) 8 (1.4) Hypoglycemia 17 (3.0) 13 (2.3) Nausea 17 (3.0) 8 (1.4) Hypertension 16 (2.8) 9 (1.6)

Hypertriglyceridemia: Patients with fasting serum TG levels above 500 mg/dL were excluded from the diabetes clinical trials. In the phase 3 diabetes trials, 637 (63%) patients had baseline fasting serum TG levels less than 200 mg/dL, 261 (25%) had baseline fasting serum TG levels between 200 and 300 mg/dL, 111 (11%) had baseline fasting serum TG levels between 300 and 500 mg/dL, and 9 (1%) had fasting serum TG levels greater than or equal to 500 mg/dL. The median baseline fasting TG concentration for the study population was 172 mg/dL; the median post-treatment fasting TG was 195 mg/dL in the Welchol group and 177 mg/dL in the placebo group. Welchol therapy resulted in a median placebo-corrected increase in serum TG of 5% (p=0.22), 22% (p<0.001), and 18% (p<0.001) when added to metformin, insulin and sulfonylureas, respectively [See Warnings and Precautions (5.2) and Clinical Studies (14.2)]. In comparison, Welchol resulted in a median increase in serum TG of 5% compared to placebo (p=0.42) in a 24-week monotherapy lipid-lowering trial [See Clinical Studies (14.1)].

Treatment-emergent fasting TG concentrations ?500 mg/dL occurred in 4.1% of Welchol-treated patients compared to 2.0% of placebo-treated patients. Among these patients, the TG concentrations with Welchol (median 604 mg/dL; interquartile range 538-712 mg/dL) were similar to that observed with placebo (median 644 mg/dL; interquartile range 574-724 mg/dL). Two (0.4%) patients on Welchol and 2 (0.4%) patients on placebo developed TG elevations ?1000 mg/dL. In all Welchol clinical trials, including studies in patients with type 2 diabetes and patients with primary hyperlipidemia, there were no reported cases of acute pancreatitis associated with hypertriglyceridemia. It is unknown whether patients with more uncontrolled, baseline hypertriglyceridemia would have greater increases in serum TG levels with Welchol [See Contraindications (4) and Warnings and Precautions (5.2)].

Cardiovascular adverse events: During the diabetes clinical trials, the incidence of patients with treatment-emergent serious adverse events involving the cardiovascular system was 3% (17/566) in the Welchol group and 2% (10/562) in the placebo group. These overall rates included disparate events (e.g., myocardial infarction, aortic stenosis, and bradycardia); therefore, the significance of this imbalance is unknown.

Hypoglycemia: Adverse events of hypoglycemia were reported based on the clinical judgment of the blinded investigators and did not require confirmation with fingerstick glucose testing. The overall reported incidence of hypoglycemia was 3.0% in patients treated with Welchol and 2.3% in patients treated with placebo. No Welchol treated patients developed severe hypoglycemia.

Post-marketing Experience

The following additional adverse reactions have been identified during post-approval use of Welchol. Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Drug Interactions with concomitant Welchol administration include:

Increased seizure activity or decreased phenytoin levels in patients receiving phenytoin. Phenytoin should be administered 4 hours prior to Welchol. Reduced International Normalized Ratio (INR) in patients receiving warfarin therapy. In warfarin-treated patients, INR should be monitored frequently during Welchol initiation then periodically thereafter. Elevated thyroid-stimulating hormone (TSH) in patients receiving thyroid hormone replacement therapy. Thyroid hormone replacement should be administered 4 hours prior to Welchol [See Drug Interactions (7)].

Gastrointestinal Adverse Reactions
Bowel obstruction (in patients with a history of bowel obstruction or resection), dysphagia (tablet and oral suspension formulations) or esophageal obstruction (occasionally requiring medical intervention), fecal impaction, pancreatitis, abdominal distension, exacerbation of hemorrhoids, and increased transaminases.

Laboratory Abnormalities
Hypertriglyceridemia

Drug Interactions

Table 4 lists the drugs that have been tested in in vitro binding or in vivo drug interaction studies with colesevelam and/or drugs with postmarketing reports consistent with potential drug-drug interactions. Orally administered drugs that have not been tested for interaction with colesevelam, especially those with a narrow therapeutic index, should also be administered at least 4 hours prior to Welchol. Alternatively, the physician should monitor drug levels of the co-administered drug.

Table 4 Drugs Tested in In Vitro Binding or In Vivo Drug Interaction Testing or With Post-Marketing Reports a Should be administered at least 4 hours prior to Welchol b No significant alteration of warfarin drug levels with warfarin and Welchol coadministration in an in vivo study which did not evaluate warfarin pharmacodynamics (INR). [See Post-marketing Experience (6.2)] c Cyclosporine levels should be monitored and, based on theoretical grounds, cyclosporine should be administered at least 4 hours prior to Welchol. Drugs with a known interaction with colesevelam Cyclosporinec, glyburidea, levothyroxinea, and oral contraceptives containing ethinyl estradiol and norethindronea Drugs with postmarketing reports consistent with potential drug-drug interactions when coadministered with Welchol phenytoina, warfarinb Drugs that do not interact with colesevelam based on in vitro or in vivo testing cephalexin, ciprofloxacin, digoxin, warfarinb fenofibrate, lovastatin, metformin, metoprolol, pioglitazone, quinidine, repaglinide, valproic acid, verapamil

In an in vivo drug interaction study, Welchol and warfarin coadministration had no effect on warfarin drug levels. This study did not assess the effect of Welchol and warfarin coadministration on INR. In postmarketing reports, concomitant use of Welchol and warfarin has been associated with reduced INR. Therefore, in patients on warfarin therapy, the INR should be monitored before initiating Welchol and frequently enough during early Welchol therapy to ensure that no significant alteration in INR occurs. Once the INR is stable, continue to monitor the INR at intervals usually recommended for patients on warfarin. [See Post-marketing Experience (6.2)]

USE IN SPECIFIC POPULATIONS Pregnancy

Pregnancy Category B. There are no adequate and well-controlled studies of colesevelam use in pregnant women. Animal reproduction studies in rats and rabbits revealed no evidence of fetal harm. Requirements for vitamins and other nutrients are increased in pregnancy. However, the effect of colesevelam on the absorption of fat-soluble vitamins has not been studied in pregnant women. This drug should be used during pregnancy only if clearly needed.

In animal reproduction studies, colesevelam revealed no evidence of fetal harm when administered to rats and rabbits at doses 50 and 17 times the maximum human dose, respectively. Because animal reproduction studies are not always predictive of human response, this drug should be used in pregnancy only if clearly needed.

Nursing Mothers

Colesevelam hydrochloride is not expected to be excreted in human milk because colesevelam hydrochloride is not absorbed systemically from the gastrointestinal tract.

Pediatric Use

 The safety and effectiveness of Welchol as monotherapy or in combination with a statin were evaluated in children, 10 to 17 years of age with heFH [See Clinical Studies (14.1)]. The adverse reaction profile was similar to that of patients treated with placebo. In this limited controlled study, there were no significant effects on growth, sexual maturation, fat-soluble vitamin levels or clotting factors in the adolescent boys or girls relative to placebo [See Adverse Reactions (6.1)].

 Due to tablet size, Welchol for Oral Suspension is recommended for use in the pediatric population. Dose adjustments are not required when Welchol is administered to children 10 to 17 years of age.

 Welchol has not been studied in children younger than 10 years of age or in pre-menarchal girls.

Geriatric Use

Primary Hyperlipidemia:  Of the 1350 patients enrolled in the hyperlipidemia clinical studies, 349 (26%) were ?65 years old, and 58 (4%) were ?75 years old. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Type 2 Diabetes Mellitus:  Of the 1128 patients enrolled in the four diabetes studies, 249 (22%) were ?65 years old, and 12 (1%) were ?75 years old. In these trials, Welchol 3.8 g/day or placebo was added onto background anti-diabetic therapy. No overall differences in safety or effectiveness were observed between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.

Hepatic Impairment

No special considerations or dosage adjustments are recommended when Welchol is administered to patients with hepatic impairment.

Renal Impairment

Type 2 Diabetes Mellitus:  Of the 1128 patients enrolled in the four diabetes studies, 696 (62%) had mild renal insufficiency (creatinine clearance [CrCl] 50-<80 mL/min), 53 (5%) had moderate renal insufficiency (CrCl 30-<50 mL/min), and none had severe renal insufficiency (CrCl <30 mL/min), as estimated from baseline serum creatinine using the Modification of Diet in Renal Disease (MDRD) equation. No overall differences in safety or effectiveness were observed between patients with CrCl <50 mL/min (n=53) and those with a CrCl?50 mL/min (n=1075).

Overdosage

Doses of Welchol in excess of 4.5 g/day have not been tested. Because Welchol is not absorbed, the risk of systemic toxicity is low. However, excessive doses of Welchol may cause more severe local gastrointestinal effects (e.g., constipation) than recommended doses.

Welchol Description

Welchol (colesevelam hydrochloride) is a non-absorbed, polymeric, lipid-lowering and glucose-lowering agent intended for oral administration. Colesevelam hydrochloride is a high-capacity bile acid-binding molecule.

Colesevelam hydrochloride is poly(allylamine hydrochloride) cross-linked with epichlorohydrin and alkylated with 1-bromodecane and (6-bromohexyl)-trimethylammonium bromide. The chemical name (IUPAC) of colesevelam hydrochloride is allylamine polymer with 1-chloro-2,3-epoxypropane, [6-(allylamino)-hexyl]trimethylammonium chloride and N-allyldecylamine, hydrochloride. The chemical structure of colesevelam hydrochloride is represented by the following formula:

wherein (a) represents allyl amine monomer units that have not been alkylated by either of the 1-bromodecane or (6-bromohexyl)-trimethylammonium bromide alkylating agents or cross-linked by epichlorohydrin; (b) represents allyl amine units that have undergone crosslinking with epichlorohydrin; (c) represents allyl amine units that have been alkylated with a decyl group; (d) represents allyl amine units that have been alkylated with a (6-trimethylammonium) hexyl group, and m represents a number ? 100 to indicate an extended polymer network. A small amount of the amines are dialkylated, and are not depicted in the formula above. No regular order of the groups is implied by the structure; cross-linking and alkylation are expected to occur randomly along the polymer chains. A large amount of the amines are protonated. The polymer is depicted in the hydrochloride form; a small amount of the halides are bromide. Colesevelam hydrochloride is hydrophilic and insoluble in water.

Welchol Tablets are an off-white, oval, film-coated, solid tablet containing 625 mg colesevelam hydrochloride. In addition, each tablet contains the following inactive ingredients: magnesium stearate, microcrystalline cellulose, silicon dioxide, HPMC (hydroxypropyl methylcellulose), and acetylated monoglyceride. The tablets are imprinted using a water-soluble black ink.

Welchol for Oral Suspension is a citrus-flavored, white to pale yellow powder containing yellow granules packaged in single-dose packets containing either 1.875 gram or 3.75 gram colesevelam hydrochloride. In addition, each packet contains the following inactive ingredients: lemon flavor, orange flavor, propylene glycol alginate, simethicone, aspartame, citric acid, medium chain triglycerides, and magnesium trisilicate.

PHENYLKETONURICS: Welchol for Oral Suspension contains 24 mg phenylalanine per 1.875 gram dose and 48 mg phenylalanine per 3.75 gram dose.

Welchol - Clinical Pharmacology Mechanism of Action

Primary Hyperlipidemia:  Colesevelam hydrochloride, the active pharmaceutical ingredient in Welchol, is a non-absorbed, lipid-lowering polymer that binds bile acids in the intestine, impeding their reabsorption. As the bile acid pool becomes depleted, the hepatic enzyme, cholesterol 7-?-hydroxylase, is upregulated, which increases the conversion of cholesterol to bile acids. This causes an increased demand for cholesterol in the liver cells, resulting in the dual effect of increasing transcription and activity of the cholesterol biosynthetic enzyme, HMG-CoA reductase, and increasing the number of hepatic LDL receptors. These compensatory effects result in increased clearance of LDL-C from the blood, resulting in decreased serum LDL-C levels. Serum TG levels may increase or remain unchanged.

Type 2 Diabetes Mellitus:  The mechanism by which Welchol improves glycemic control is unknown.

Pharmacodynamics

A maximum therapeutic response to the lipid-lowering effects of Welchol was achieved within 2 weeks and was maintained during long-term therapy. In the diabetes clinical studies, a therapeutic response to Welchol, as reflected by a reduction in hemoglobin A1C (A1C), was initially noted following 4-6 weeks of treatment and reached maximal or near-maximal effect after 12-18 weeks of treatment.

Pharmacokinetics

Absorption:  Colesevelam hydrochloride is a hydrophilic, water-insoluble polymer that is not hydrolyzed by digestive enzymes and is not absorbed.

Distribution:  Colesevelam hydrochloride is not absorbed, and therefore, its distribution is limited to the gastrointestinal tract.

Metabolism:  Colesevelam hydrochloride is not metabolized systemically and does not interfere with systemic drug-metabolizing enzymes such as cytochrome P-450.

Excretion:  In 16 healthy volunteers, an average of 0.05% of administered radioactivity from a single 14C-labeled colesevelam hydrochloride dose was excreted in the urine.

Drug Interactions:  Drug interactions between colesevelam and concomitantly administered drugs were screened through in vitro studies and confirmed in in vivo studies. In vitro studies demonstrated that cephalexin, metformin, and ciprofloxacin had negligible binding to colesevelam hydrochloride. Therefore, an in vivo pharmacokinetic interaction of Welchol with these drugs is unlikely. Welchol was found to have no significant effect on the bioavailability of digoxin, fenofibrate, lovastatin, metoprolol, quinidine, valproic acid, pioglitazone, and warfarin. The results of additional in vivo drug interactions of Welchol are presented in Table 5.

Drug interactions between Welchol and other commonly co-administered drugs in patients with type 2 diabetes (including rosiglitazone maleate, glimepiride, glipizide, sitagliptin phosphate, angiotensin converting enzyme inhibitors, angiotensin receptor blockers, sustained-release formulations of anti-diabetic and anti-hypertensive drugs, and aspirin) have not been evaluated.

Table 5 Mean Change in Drug Exposure (AUC0-? and Cmax) when Administered with Welchol (3.75 g)a a With verapamil, the dose of Welchol was 4.5 g b Should be administered at least 4 hours prior to Welchol. [See Drug Interactions (7)] * Oral contraceptive containing norethindrone and ethinyl estradiol. N/A — Not Available
Drug
Dose
Co-administered
1 hr prior to
Welchol
4 hr prior to
Welchol AUC0-? Cmax AUC0-? Cmax AUC0-? Cmax Verapamil sustained-release 240 mg -31% -11% N/A N/A N/A N/A Glyburideb 3 mg -32% -47% -20% -15% -7% 4% Levothyroxineb 600 µg -22% -33% 6% -2% 1% 8% Norethindrone*b 1 mg -1% -20% 5% -3% 6% 7% Ethinyl Estradiol*b 0.035 mg -24% -24% -18% -1% -12% 0% Repaglinide 2 mg -7% -19% -6% -1% N/A N/A Cyclosporine 200 mg -34% -44% N/A N/A N/A N/A Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment of Fertility

Carcinogenesis:  A 104-week carcinogenicity study with colesevelam hydrochloride was conducted in CD-1 mice, at oral dietary doses up to 3 g/kg/day. This dose was approximately 50 times the maximum recommended human dose of 4.5 g/day, based on body weight, mg/kg. There were no significant drug-induced tumor findings in male or female mice. In a 104-week carcinogenicity study with colesevelam hydrochloride in Harlan Sprague-Dawley rats, a statistically significant increase in the incidence of pancreatic acinar cell adenoma was seen in male rats at doses >1.2 g/kg/day (approximately 20 times the maximum human dose, based on body weight, mg/kg) (trend test only). A statistically significant increase in thyroid C-cell adenoma was seen in female rats at 2.4 g/kg/day (approximately 40 times the maximum human dose, based on body weight, mg/kg).

Mutagenesis:  Colesevelam hydrochloride and 4 degradants present in the drug substance have been evaluated for mutagenicity in the Ames test and a mammalian chromosomal aberration test. The 4 degradants and an extract of the parent compound did not exhibit genetic toxicity in an in vitro bacterial mutagenesis assay in S.typhimurium and E. coli (Ames assay) with or without rat liver metabolic activation. An extract of the parent compound was positive in the Chinese Hamster Ovary (CHO) cell chromosomal aberration assay in the presence of metabolic activation and negative in the absence of metabolic activation. The results of the CHO cell chromosomal aberration assay with 2 of the 4 degradants, decylamine HCl and aminohexyltrimethyl ammonium chloride HCl, were equivocal in the absence of metabolic activation and negative in the presence of metabolic activation. The other 2 degradants, didecylamine HCl and 6-decylamino-hexyltrimethyl ammonium chloride HCl, were negative in the presence and absence of metabolic activation.

Impairment of Fertility:  Colesevelam hydrochloride did not impair fertility in rats at doses up to 3 g/kg/day (approximately 50 times the maximum human dose, based on body weight, mg/kg).

Animal Toxicology and/or Pharmacology

Reproductive Toxicology Studies
      Reproduction studies have been performed in rats and rabbits at doses up to 3 g/kg/day and 1 g/kg/day, respectively (approximately 50 and 17 times the maximum human dose, based on body weight, mg/kg) and have revealed no evidence of harm to the fetus due to colesevelam hydrochloride.

Clinical Studies Primary Hyperlipidemia

Welchol reduces TC, LDL-C, apolipoprotein B (Apo B), and non-HDL-C when administered alone or in combination with a statin in patients with primary hyperlipidemia.

Approximately 1600 patients were studied in 9 clinical trials with treatment durations ranging from 4 to 50 weeks. With the exception of one open-label, uncontrolled, long-term extension study, all studies were multicenter, randomized, double-blind, and placebo-controlled. A maximum therapeutic response to Welchol was achieved within 2 weeks and was maintained during long-term therapy.

Monotherapy:  In a study in patients with LDL-C between 130 mg/dL and 220 mg/dL (mean 158 mg/dL), Welchol was given for 24 weeks in divided doses with the morning and evening meals.

As shown in Table 6, the mean LDL-C reductions were 15% and 18% at the 3.8 g and 4.5 g doses. The respective mean TC reductions were 7% and 10%. The mean Apo B reductions were 12% in both treatment groups. Welchol at both doses increased HDL-C by 3%. Increases in TG of 9-10% were observed at both Welchol doses but the changes were not statistically different from placebo.

Table 6 Response to Welchol Monotherapy in a 24-Week Trial - Percent Change in Lipid Parameters from Baseline * p<0.05 for lipid parameters compared to placebo, for Apo B compared to baseline. a Median % change from baseline. Grams/Day N TC LDL-C Apo B HDL-Ca Non-HDL-C TGa Placebo 88 +1 0 0 -1 +1 +5 3.8 g (6 tablets) 95 -7* -15* -12* +3* -10* +10 4.5 g (7 tablets) 94 -10* -18* -12* +3 -13* +9

In a study in 98 patients with LDL-C between 145 mg/dL and 250 mg/dL (mean 169 mg/dL), Welchol 3.8 g was given for 6 weeks as a single dose with breakfast, as a single dose with dinner, or as divided doses with breakfast and dinner. The mean LDL-C reductions were 18%, 15%, and 18% for the 3 dosing regimens, respectively. The reductions with these 3 regimens were not statistically different from one another.

Combination Therapy: Co-administration of Welchol and a statin (atorvastatin, lovastatin, or simvastatin) in 3 clinical studies demonstrated an additive reduction of LDL-C. The mean baseline LDL-C was 184 mg/dL in the atorvastatin stu


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Anticholinergic bronchodilators


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Anticholinergic bronchodilators (or muscarinic receptor antagonists) block the parasympathetic nerve reflexes that cause the airways to constrict, so allow the air passages to remain open. Muscarinic receptor antagonists bind to muscarinic receptors and inhibit acetylcholine mediated bronchospasm.

Anticholinergic bronchodilators are used more to treat chronic obstructive pulmonary disease than to treat asthma.

See also

Medical conditions associated with anticholinergic bronchodilators:

AsthmaCOPD, Maintenance Drug List:/tags/atrovent/
Atrovent-Hfa-Aerosol-Suspension
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Monoclonal antibodies


Monoclonal antibodies used in immunotherapy are produced artificially from a cell clone therefore consist of a single type of immunoglobulin. They are targeted towards specific antigens and bind to the antigens to form a complex. The monoclonal antibody-antigen complex can be recognized and destroyed by phagocytes or it can used for other diagnostic purposes.

Natural antibodies are proteins made by the B-lymphocytes in response to antigens. Each B-cell makes only one type of antibody. For therapeutic purposes a significant amount of a particular antibody is needed. These are obtained from a culture that gives one type of antibody, which are called monoclonal antibodies.

Monoclonal antibodies are used as chemotherapeutic agents to treat malignant tumors and viral infections. They are also used in tests to detect AIDS (acquired immunodeficiency syndrome) and in pregnancy test kits.

See also anti-CTLA-4 monoclonal antibodies antineoplastic monoclonal antibodies CD20 monoclonal antibodies CD30 monoclonal antibodies CD33 monoclonal antibodies CD52 monoclonal antibodies RANK ligand inhibitors trifunctional monoclonal antibodies Drug List:
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Antineoplastic monoclonal antibodies


Monoclonal antibodies used in immunotherapy are produced artificially from a cell clone therefore consist of a single type of immunoglobulin. They are targeted towards specific antigens and bind to the antigens to form a complex. The complex can be recognized and destroyed by phagocytes and macrophages. These complexes can also be used for other diagnostic purposes.

Natural antibodies are proteins made by the B-lymphocytes in response to antigens. Each B-cell makes only one type of antibody. For therapeutic purposes a significant amount of a particular antibody is needed. These are obtained from a culture that gives one type of antibody, which are called monoclonal antibodies.

Use of monoclonal antibodies work by various mechanisms to treat cancer. They enhance the immune reaction to destroy cancer cells of certain types of cancers that have particular surface antigens.

Monoclonal antibodies can also be directed towards other cells and molecules needed for the growth of tumors, therefore inhibits the growth of the cancer cells. They can be conjugated chemotherapy drugs, radioactive drugs, or to toxins that can attack the cancer cells. By conjugating these agents to the monoclonal antibodies, these agents are delivered directly to the tumor cells when the monoclonal antibody binds to the specific surface antigens on the tumor cells.

Drug List:
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Alkylating agents


A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Alkylating agents are a class of chemotherapy drugs that bind to DNA and prevent proper DNA replication. They have chemical groups that can form permanent covalent bonds with nucleophilic substances in the DNA.

Alkylating agents are used as part of chemotherapy in different types of cancers.

See also

Medical conditions associated with alkylating agents:

Acute Lymphocytic Leukemia Acute Nonlymphocytic Leukemia Anaplastic Astrocytoma Anaplastic Oligodendroglioma Bladder Cancer Blood Cell Transplantation Bone Marrow Transplantation Brain Tumor Breast Cancer Bullous Pemphigoid Cancer Cervical Cancer Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia Cogan's Syndrome Colorectal Cancer Dermatomyositis Endometrial Cancer Ewing's Sarcoma Glioblastoma Multiforme Histiocytosis Hodgkin's Lymphoma IgA Nephropathy Lymphoma Malignant Glioma Melanoma Melanoma, Metastatic Multiple Myeloma Multiple Sclerosis Mycosis Fungoides Nephrotic Syndrome Neuroblastoma Non-Hodgkin's Lymphoma Non-Small Cell Lung Cancer Organ Transplant, Rejection Prophylaxis Osteogenic Sarcoma Osteosarcoma Ovarian Cancer Pancreatic Cancer Pemphigoid Pemphigus Prostate Cancer Rheumatoid Arthritis Serosal Cavity Neoplastic Disease Small Cell Lung Cancer Systemic Lupus Erythematosus Systemic Sclerosis Testicular Cancer Thrombocythemia Wegener's Granulomatosus Wilms' Tumor Drug List: Cytoxan Myleran Leukeran Paraplatin Treanda Neosar Temodar Alkeran Bicnu Busulfex Ceenu Cytoxan-Lyophilized-Oral-Injection Dtic-Dome Eloxatin Gliadel-Implant-Wafer Ifex-Solution Mustargen Platinol Platinol-Aq Thioplex Zanosar
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Trilipix


Generic Name: fenofibric acid (FEN oh FYE brik AS id)
Brand Names: Fibricor, Trilipix

What is fenofibric acid?

Fenofibric acid helps reduce cholesterol and triglycerides (fatty acids) in the blood. High levels of these types of fat in the blood are associated with an increased risk of atherosclerosis (clogged arteries).

Fenofibric acid is used to treat high cholesterol and high triglyceride levels. It is sometimes given together with other cholesterol-lowering medications.

Fenofibric acid may also be used for purposes not listed in this medication guide.

What is the most important information I should know about fenofibric acid? You should not take fenofibric acid if you are allergic to it, or if you have liver disease, gallbladder disease, severe kidney disease (or if you are on dialysis), or if you are breast-feeding a baby.

Before you take fenofibric acid, tell your doctor if you have kidney disease, diabetes, or underactive thyroid.

Fenofibric acid is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Avoid eating foods that are high in fat or cholesterol. Fenofibric acid will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

In rare cases, fenofibric acid can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. What should I discuss with my healthcare provider before taking fenofibric acid? You should not take fenofibric acid if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); liver disease;

gallbladder disease; or

if you are breast-feeding a baby.

To make sure you can safely take fenofibric acid, tell your doctor if you have any of these other conditions:

kidney disease;

diabetes; or

underactive thyroid.

FDA pregnancy category C. It is not known whether fenofibric acid will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Do not breast-feed while you are taking fenofibric acid. How should I take fenofibric acid?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

You may take fenofibric acid with or without food.

If you also take cholestyramine (Questran), colesevelam (Welchol), or colestipol (Colestid), take these medicines at least 1 hour after taking fenofibric acid, or 4 to 6 hours before taking fenofibric acid. Do not take any of these medicines at the same time you take fenofibric acid.

"Statin" cholesterol-lowering medications may be taken at the same time as fenofibric acid.

Fenofibric acid is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.

To be sure this medicine is helping your condition and is not causing harmful effects, your blood will need to be tested often. Your liver, kidney, and gallbladder function may also need to be tested. Visit your doctor regularly.

Store at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking fenofibric acid?

Avoid eating foods that are high in fat or cholesterol. Fenofibric acid will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. Fenofibric acid side effects In rare cases, fenofibric acid can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Stop taking fenofibric acid and call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using fenofibric acid and call your doctor at once if you have a serious side effect such as:

sharp stomach pain spreading to your back or shoulder blade;

stomach pain just after eating a meal;

nausea, vomiting, fever, clay-colored stools, jaundice (yellowing of the skin or eyes);

pain, swelling, warmth, or redness in one or both legs;

chest pain, sudden cough, wheezing, rapid breathing, fast heart rate.

Less serious side effects may include:

headache, dizziness;

back pain;

joint pain;

diarrhea, upset stomach; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect fenofibric acid?

Tell your doctor about all other medications you use, especially:

cyclosporine (Neoral, Sandimmune, Gengraf);

a blood thinner such as warfarin (Coumadin);

a diuretic (water pill);

birth control pills or hormone replacement therapy; or

a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.

This list is not complete and other drugs may interact with fenofibric acid. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Trilipix resources Trilipix Side Effects (in more detail) Trilipix Use in Pregnancy & Breastfeeding Trilipix Drug Interactions Trilipix Support Group 13 Reviews for Trilipix - Add your own review/rating Trilipix Prescribing Information (FDA) Trilipix Consumer Overview Trilipix Advanced Consumer (Micromedex) - Includes Dosage Information Trilipix Delayed-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer) Fenofibric Acid MedFacts Consumer Leaflet (Wolters Kluwer) Fenofibric Acid Prescribing Information (FDA) Fibricor Prescribing Information (FDA) Compare Trilipix with other medications High Cholesterol Hypertriglyceridemia Where can I get more information? Your pharmacist can provide more information about fenofibric acid.

See also: Trilipix side effects (in more detail)


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sevelamer


Generic Name: sevelamer (se VEL a mer)
Brand Names: Renagel, Renvela

What is sevelamer?

Sevelamer is a phosphate binder. Sevelamer helps prevent hypocalcemia (low levels of calcium in the body) caused by elevated phosphorus.

Sevelamer is used to reduce blood levels of phosphorus in people with chronic kidney disease who are on dialysis.

Sevelamer may also be used for purposes not listed in this medication guide.

What is the most important information I should know about sevelamer? You should not take this medication if you are allergic to sevelamer, or if you have a bowel obstruction.

Before taking sevelamer, tell your doctor if you have trouble swallowing, severe constipation, a blockage in your intestines, a stomach or intestinal disorder, or if you have recently had stomach or intestinal surgery.

Avoid taking any other medicines within 1 hour before or 3 hours after you take sevelamer. Sevelamer can bind to other medications and make them less effective.

Before taking sevelamer, tell your doctor if you are taking ciprofloxacin (Cipro), a heart rhythm medication, or a seizure medication.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends. What should I discuss with my healthcare provider before taking sevelamer? You should not take this medication if you are allergic to sevelamer, or if you have a bowel obstruction.

To make sure you can safely take sevelamer, tell your doctor if you have any of these other conditions:

trouble swallowing;

severe constipation;

a blockage in your intestines;

a stomach or intestinal disorder; or

if you have recently had stomach or intestinal surgery.

FDA pregnancy category C. It is not known whether sevelamer will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether sevelamer passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take sevelamer?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take sevelamer with meals. Do not crush, chew, or break the sevelamer tablet. Swallow the pill whole. Sevelamer tablets expand when they are wet, and breaking or crushing the pill may make it harder to swallow.

Sevelamer powder must be dissolved in water before you take it. The 0.8-gram packet should be mixed with at least 1 ounce (2 tablespoons) of water. The 2.4-gram packet should be mixed with at least 2 ounces (4 tablespoons) of water.

Stir the powder in water until it is completely dissolved. Drink all of this mixture right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

To be sure this medication is helping your condition and not causing harmful effects, your blood may need to be tested on a regular basis. Do not miss any scheduled appointments.

Sevelamer may be only part of a complete program of treatment that also includes a special diet. It is very important to follow the diet plan created for you by your doctor or nutrition counselor. You should become very familiar with the list of foods you must eat or avoid to help control your condition.

Store at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. Be sure to take the missed dose with food. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking sevelamer?

Avoid taking any other medicines within 1 hour before or 3 hours after you take sevelamer. Sevelamer can bind to other medications and make them less effective.

Do not take calcium or other mineral supplements without your doctor's advice. Use only the specific type of calcium or mineral supplement your doctor recommends. Sevelamer side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using sevelamer and call your doctor at once if you have a serious side effect such as:

black, bloody, or tarry stools;

constipation that gets worse or does not clear up;

severe constipation with stomach pain; or

fever, chills, body aches, flu symptoms.

Less serious side effects may include:

nausea, vomiting, stomach pain, loss of appetite;

upset stomach, gas, bloating;

diarrhea, mild constipation;

tired feeling;

itching; or

joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sevelamer Dosing Information

Usual Adult Dose for Hyperphosphatemia of Renal Failure:

Initial:
Dialysis patients not taking a phosphate binder:
Sevelamer carbonate:
800 mg to 1600 mg orally three times daily with each meal based on serum phosphorus level:
Phosphorus greater than 5.5 and less than 7.5 mg/dL = 800 mg
Phosphorus greater than or equal to 7.5 and less than 9.0 mg/dL = 1600 mg
Phosphorus greater than or equal to 9.0 mg/dL = 1600 mg
Sevelamer hydrochloride: Renagel(R):
Phosphorus greater than 5.5 and less than 7.5 mg/dL = One 800 mg tablet or two 400 mg tablets orally 3 times daily with meals
Phosphorus greater than or equal to 7.5 and less than 9.0 mg/dL = Two 800 mg tablets or three 400 mg tablets orally 3 times daily with meals
Phosphorus greater than or equal to 9.0 mg/dL = Two 800 mg tablets or four 400 mg tablets orally 3 times daily with meals
Patients switching from calcium acetate to sevelamer:
Sevelamer carbonate: For each calcium acetate 667 mg tablet used per meal, give sevelamer carbonate 800 mg per meal.
Sevelamer hydrochloride: Renagel(R):
One calcium acetate 667 mg tablet per meal: Substitute one sevelamer hydrochloride 800 mg or two sevelamer hydrochloride 400 mg tablets per meal.
Two calcium acetate 667 tablets mg per meal: Substitute two sevelamer hydrochloride 800 mg or three sevelamer hydrochloride 400 mg tablets per meal.
Three calcium acetate 667 tablets mg per meal: Substitute three sevelamer hydrochloride 800 mg or five sevelamer hydrochloride 400 mg tablets per meal.
Patients switching from sevelamer hydrochloride to sevelamer carbonate: Dosage should be prescribed on a gram per gram basis.
Maximum daily dose studied for sevelamer hydrochloride is 13,000 mg and for carbonate is 14,000 mg.

Usual Pediatric Dose for Hyperphosphatemia of Renal Failure:

In a small pilot study of 17 pediatric patients aged 11.8 plus or minus 3.7 years on hemodialysis (n=3) or peritoneal dialysis (n=14), initial doses of 121 plus or minus 50 mg/kg/day (4.5 plus or minus 5 g/day) were used. Doses were adjusted based on the serum phosphorus with final doses of 163 plus or minus 46 mg/kg (6.7 plus or minus 2.4 gm/day) without any adverse effects (Mahdavi, 2003). In a study of 18 patients aged 0.9 to 18 years with chronic kidney disease, a mean dose of 140 plus or minus 86 mg/kg/day (5.38 plus or minus 3.24 g/day) resulted in good phosphorus control with minimal adverse effects. Initial doses were based on prior phosphate binder dose and were adjusted based on the serum phosphorus (Pieper, 2006).

What other drugs will affect sevelamer?

Tell your doctor about all other medicines you use, especially:

ciprofloxacin (Cipro);

levothyroxine (Synthroid, Levothroid, Levoxyl);

a heart rhythm medication; or

a seizure medication.

This list is not complete and other drugs may interact with sevelamer. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More sevelamer resources Sevelamer Side Effects (in more detail) Sevelamer Use in Pregnancy & Breastfeeding Sevelamer Drug Interactions Sevelamer Support Group 1 Review for Sevelamer - Add your own review/rating sevelamer Advanced Consumer (Micromedex) - Includes Dosage Information Sevelamer Professional Patient Advice (Wolters Kluwer) Sevelamer Monograph (AHFS DI) Sevelamer MedFacts Consumer Leaflet (Wolters Kluwer) Renagel Prescribing Information (FDA) Renagel Consumer Overview Renvela Prescribing Information (FDA) Renvela Consumer Overview Compare sevelamer with other medications Hyperphosphatemia of Renal Failure Where can I get more information? Your pharmacist can provide more information about sevelamer.

See also: sevelamer side effects (in more detail)


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PhosLo


Generic Name: calcium acetate (KAL see um AH seh tate)
Brand Names: Eliphos, PhosLo Gelcap

What is PhosLo (calcium acetate)?

Calcium is a mineral that is needed for many functions of the body, especially bone formation and maintenance. Calcium can also bind to other minerals such as phosphate, and aid in their removal from the body.

Calcium acetate is used to control phosphate levels to keep them from getting too high in people with kidney failure.

Calcium acetate may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about PhosLo (calcium acetate)? Do not use this medication if you have high levels of calcium in your blood, or if you are also taking digoxin (digitalis, Lanoxin, Lanoxicaps). Do not take additional calcium supplements unless your doctor has told you to.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Many antacids contain calcium and you could be getting too much of this mineral if you take a calcium antacid with calcium acetate.

What should I discuss with my healthcare provider before taking PhosLo (calcium acetate)? Do not use this medication if you have high levels of calcium in your blood, or if you are also taking digoxin (digitalis, Lanoxin, Lanoxicaps).

Before taking this medication, tell your doctor if you are allergic to any drugs.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether calcium acetate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take PhosLo (calcium acetate)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take this medication with each meal, unless your doctor tells you otherwise.

You may need to keep a food diary to measure how much calcium you are getting in your diet.

To be sure this medication is helping your condition and not causing harmful side effects, your blood will need to be tested on a regular basis. You may also need x-rays to check for calcium deposits around your joints or other soft tissues. Do not miss any scheduled appointments.

Store calcium acetate at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. Be sure to take the medicine with food. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, loss of appetite, dry mouth, increased thirst or urination, constipation, confusion, fainting, or coma.

What should I avoid while taking PhosLo (calcium acetate)? Do not take additional calcium supplements unless your doctor has told you to.

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Many antacids contain calcium and you could be getting too much of this mineral if you take a calcium antacid with calcium acetate.

PhosLo (calcium acetate) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely to occur, such as:

nausea, vomiting, loss of appetite;

constipation;

dry mouth or increased thirst; or

urinating more than usual.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect PhosLo (calcium acetate)?

Before taking calcium acetate, tell your doctor if you are using any of the following drugs:

demeclocycline (Declomycin);

doxycycline (Adoxa, Doryx, Oracea, Vibramycin);

minocycline (Dynacin, Minocin, Solodyn, Vectrin); or

tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and there may be other drugs that can interact with calcium acetate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More PhosLo resources PhosLo Side Effects (in more detail) PhosLo Use in Pregnancy & Breastfeeding Drug Images PhosLo Drug Interactions PhosLo Support Group 0 Reviews for PhosLo - Add your own review/rating PhosLo MedFacts Consumer Leaflet (Wolters Kluwer) PhosLo Advanced Consumer (Micromedex) - Includes Dosage Information Eliphos Prescribing Information (FDA) Phoslo Prescribing Information (FDA) Phoslyra Prescribing Information (FDA) Phoslyra Solution MedFacts Consumer Leaflet (Wolters Kluwer) Compare PhosLo with other medications Hyperphosphatemia Where can I get more information? Your pharmacist can provide more information about calcium acetate.

See also: PhosLo side effects (in more detail)


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calcium lactate


Generic Name: calcium lactate (KAL see um LAK tate)
Brand Names: Ridactate

What is calcium lactate?

Calcium is a mineral that is found naturally in foods. Calcium is necessary for many normal functions of your body, especially bone formation and maintenance. Calcium can also bind to other minerals (such as phosphate) and aid in their removal from the body.

Calcium lactate is used to prevent and to treat calcium deficiencies.

Calcium lactate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about calcium lactate? Do not take calcium lactate or antacids that contain calcium without first asking your doctor if you also take other medicines. Calcium can make it harder for your body to absorb certain medicines. Calcium lactate works best if you take it with food. What should I discuss with my healthcare provider before taking calcium lactate?

Before taking this medication, tell your doctor if you have:

a history of kidney stones; or

a parathyroid gland disorder.

If you have any of these conditions, you may not be able to take calcium lactate, or you may need a dose adjustment or special tests during treatment.

Talk to your doctor before taking calcium lactate if you are pregnant. Talk to your doctor before taking calcium lactate if you are breast-feeding a baby. How should I take calcium lactate?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Calcium lactate works best if you take it with food. Take calcium lactate with a full glass of water. Store at room temperature away from moisture and heat.

See also: Calcium lactate dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, decreased appetite, constipation, confusion, delirium, stupor, and coma.

What should I avoid while taking calcium lactate?

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

Calcium lactate side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

nausea or vomiting;

decreased appetite;

constipation;

dry mouth or increased thirst; or

increased urination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Calcium lactate Dosing Information

Usual Adult Dose for Hypocalcemia:

325 to 650 mg orally 2 to 3 times a day before meals. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Osteomalacia:

325 to 650 mg orally 2 to 3 times a day before meals. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Hypoparathyroidism:

325 mg orally 3 times a day before meals. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Pseudohypoparathyroidism:

325 mg orally once a day before the breakfast meal. Treatment may also consist of vitamin D orally.

Usual Adult Dose for Osteoporosis:

325 to 650 mg orally 3 times a day before meals. Osteoporosis can be affected by increased serum parathyroid hormone, excessive alcohol intake, tobacco use, certain drugs (corticosteroids, anticonvulsants, heparin, thyroid hormone), dietary vitamin D, and weight bearing exercise.

Usual Pediatric Dose for Hypocalcemia:

Neonatal:
Oral:
Hypocalcemia (dose depends on clinical condition and serum calcium level):
Dose expressed in mg of elemental calcium: 50 to 150 mg/kg/day in 4 to 6 divided doses; not to exceed 1 g/day
Dose expressed in mg of calcium lactate: 400 to 500 mg/kg/day divided every 4 to 6 hours
Oral:
Hypocalcemia (dose depends on clinical condition and serum calcium level):
Dose expressed in mg of elemental calcium:
Children: 45 to 65 mg/kg/day in 4 divided doses
Dose expressed in mg of calcium lactate:
Infants: 400 to 500 mg/kg/day divided every 4 to 6 hours
Children: 500 mg/kg/day divided every 6 to 8 hours; maximum daily dose: 9 g

What other drugs will affect calcium lactate?

Calcium lactate can make it harder for your body to absorb other medications you take by mouth. Tell your doctor if you are taking:

digoxin (Lanoxin, Lanoxicaps);

antacids or other calcium supplements;

calcitriol (Rocaltrol) or vitamin D supplements; or

doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with calcium lactate. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More calcium lactate resources Calcium lactate Side Effects (in more detail) Calcium lactate Dosage Calcium lactate Use in Pregnancy & Breastfeeding Calcium lactate Drug Interactions Calcium lactate Support Group 0 Reviews for Calcium lactate - Add your own review/rating Compare calcium lactate with other medications Hypocalcemia Hypoparathyroidism Osteomalacia Osteoporosis Pseudohypoparathyroidism Where can I get more information? Your doctor or pharmacist can provide more information about calcium lactate.

See also: calcium lactate side effects (in more detail)


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CIP - Fenofibrate


Pronunciation: FEN-oh-FYE-brate
Generic Name: CIP - Fenofibrate
Brand Name: Lipofen
CIP - Fenofibrate is used for:

Controlling high cholesterol and triglyceride levels in the blood. It is used in combination with a diet low in cholesterol and saturated fat.

CIP - Fenofibrate is a lipid-lowering agent. It works by lowering elevated blood triglyceride levels by making the liver produce fewer triglycerides and increasing the elimination of triglycerides from the blood stream.

Do NOT use CIP - Fenofibrate if: you are allergic to any ingredient in CIP - Fenofibrate you have gallbladder problems, liver problems (eg, cirrhosis, hepatitis), or severe kidney problems (eg, kidney failure) you are breast-feeding or pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using CIP - Fenofibrate:

Some medical conditions may interact with CIP - Fenofibrate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines or other substances if you have diabetes, an underactive thyroid, heart blood vessel problems, gallstones, kidney problems, or certain muscle problems (myopathy) if you have a history of pancreatitis or blood clots in your veins (deep vein thrombosis or pulmonary embolism) if you are very overweight, have an inactive lifestyle, or you drink large amounts of alcohol if you are taking a beta-blocker (eg, propranolol), estrogen, or thiazide diuretic (eg, hydrochlorothiazide)

Some MEDICINES MAY INTERACT with CIP - Fenofibrate. Tell your health care provider if you are taking any other medicines, especially any of the following:

HMG-CoA reductase inhibitors (eg, simvastatin) because the risk of serious muscle problems leading to kidney failure may be increased Immunosuppressants (eg, cyclosporine) or other medicines that may harm the kidney (eg, aminoglycoside antibiotics [eg, gentamicin], amphotericin B, nonsteroidal anti-inflammatory drugs [NSAIDs] [eg, ibuprofen], tacrolimus, vancomycin) because they may decrease CIP - Fenofibrate's excretion and increase the risk of its side effects Anticoagulants (eg, warfarin) or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by CIP - Fenofibrate

This may not be a complete list of all interactions that may occur. Ask your health care provider if CIP - Fenofibrate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use CIP - Fenofibrate:

Use CIP - Fenofibrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take CIP - Fenofibrate by mouth with a meal. Swallow CIP - Fenofibrate whole. Do not break, crush, or chew before swallowing. Take CIP - Fenofibrate with a full glass of water (8 oz/240 mL). If you also take a bile acid-binding resin (eg, cholestyramine), do not take it within 4 to 6 hours before or 1 hour after taking CIP - Fenofibrate. Check with your doctor if you have any questions. Take CIP - Fenofibrate on a regular schedule to get the most benefit from it. If you miss a dose of CIP - Fenofibrate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use CIP - Fenofibrate.

Important safety information: CIP - Fenofibrate may cause dizziness or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use CIP - Fenofibrate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Avoid drinking alcohol while you are using CIP - Fenofibrate. Do NOT take more than the recommended dose without checking with your doctor. Follow the diet, exercise, and weight reduction program given to you by your health care provider. Report any unexplained muscle pain, tenderness, or weakness to your doctor right away, especially if you also have a fever or general body discomfort. Lab tests, including liver function, kidney function, blood cholesterol, and other blood tests, may be performed while you use CIP - Fenofibrate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use CIP - Fenofibrate with caution in the ELDERLY; they may be more sensitive to its effects. CIP - Fenofibrate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using CIP - Fenofibrate while you are pregnant. It is not known if CIP - Fenofibrate is found in breast milk. Do not breast-feed while taking CIP - Fenofibrate. Possible side effects of CIP - Fenofibrate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Headache; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); calf pain; chest pain; confusion; dark urine; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; increased coughing or coughing up blood; muscle pain, tenderness, or weakness (with or without fever and fatigue); pale stools; red, swollen, blistered or peeling skin; severe or persistent dizziness or lightheadedness; severe or persistent nausea, stomach pain, or vomiting; severe pain or swelling in the ankles, feet, or legs; shortness of breath; unusual bruising or bleeding; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: CIP - Fenofibrate side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of CIP - Fenofibrate:

Store CIP - Fenofibrate between 68 and 77 degrees F (20 and 25 degrees C) in a moisture-protective container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Protect from heat, moisture, and light. Do not store in the bathroom. Keep CIP - Fenofibrate out of the reach of children and away from pets.

General information: If you have any questions about CIP - Fenofibrate, please talk with your doctor, pharmacist, or other health care provider. CIP - Fenofibrate is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about CIP - Fenofibrate. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012 Database Edition 12.1.1.002 Copyright © 2012 Wolters Kluwer Health, Inc. More CIP - Fenofibrate resources CIP - Fenofibrate Side Effects (in more detail)CIP - Fenofibrate Use in Pregnancy & BreastfeedingDrug ImagesCIP - Fenofibrate Drug InteractionsCIP - Fenofibrate Support Group16 Reviews for CIP - Fenofibrate - Add your own review/rating Compare CIP - Fenofibrate with other medications HyperlipoproteinemiaHyperlipoproteinemia Type IIa, Elevated LDLHyperlipoproteinemia Type IIb, Elevated LDL VLDLHyperlipoproteinemia Type IV, Elevated VLDLHyperlipoproteinemia Type V, Elevated Chylomicrons VLDLHypertriglyceridemia
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Laxmar Orange


Generic Name: psyllium (SIL ee um)
Brand Names: Fiberall, Hydrocil, Konsyl, Konsyl Orange Sugar-free, Konsyl-D, Konsyl-Orange, Laxmar, Laxmar Orange, Laxmar Sugar Free, Metamucil, Metamucil Berry Burst Smooth Texture Sugar Free, Metamucil Orange Coarse Milled Original Texture, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Original Texture Regular, Metamucil Pink Lemonade Smooth Texture Sugar-Free, Metamucil Unflavored Coarse Milled Original Texture, Metamucil Unflavored Smooth Texture Sugar Free, Natural Fiber Therapy, Perdiem Fiber Powder, Reguloid

What is Laxmar Orange (psyllium)?

Psyllium is a bulk-forming fiber laxative. Psyllium works by absorbing liquid in the intestines and swelling to create a softer, bulky stool that is easier to pass.

Psyllium is used to treat occasional constipation or bowel irregularity. Psyllium may also be used to treat diarrhea and may help lower cholesterol when used together with a diet low in cholesterol and saturated fat.

Psyllium may also be used for purposes not listed in this product guide.

What is the most important information I should know about Laxmar Orange (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have trouble swallowing, a sudden change in bowel habits that lasts longer than 2 weeks, severe nausea, vomiting, or stomach pain, or if you have ever had a skin rash while taking psyllium.

Also talk with your doctor before using psyllium if you have a colostomy or ileostomy, rectal bleeding, or a blockage in your intestines.

Stop using psyllium and call your doctor at once if you have choking or trouble swallowing, severe stomach pain or cramping, nausea or vomiting, constipation that lasts longer than 7 days, rectal bleeding, or itchy skin rash. Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. What should I discuss with my healthcare provider before taking Laxmar Orange (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have:

trouble swallowing;

a sudden change in bowel habits that lasts longer than 2 weeks;

severe nausea, vomiting, or stomach pain; or

if you have ever had a skin rash while taking psyllium.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

a colostomy or ileostomy;

rectal bleeding; or

a blockage in your intestines.

Psyllium products may contain sugar, sodium, or artificial sweeteners. This may be of concern to you if you have diabetes, high blood pressure, or phenylketonuria (PKU). Check the product label if you have any of these conditions.

Psyllium is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether psyllium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Laxmar Orange (psyllium)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take psyllium with a full glass (at least 8 ounces) of water or another liquid. Taking psyllium without enough liquid may cause it to swell in your throat and cause choking. Drinking plenty of fluids each day while you are taking psyllium will also help improve bowel regularity.

The psyllium wafer must be chewed before you swallow it.

Do not swallow psyllium powder dry. It must be mixed with liquid. Place the psyllium powder into an empty glass and add at least 8 ounces of water or other liquid such as fruit juice. Stir this mixture and drink all of it right away.

If the powder and liquid mixture is too thick, add more liquid. After drinking the entire mixture, add a little more liquid to the same glass, swirl gently and drink right away to make sure you get the entire dose of psyllium.

Psyllium may be only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

It may take up to 3 days of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 or 3 days of treatment.

Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Since psyllium is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using psyllium.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and stomach pain. Using a laxative too often or for too long may cause severe medical problems involving your intestines.

What should I avoid while taking Laxmar Orange (psyllium)?

Avoid taking other oral (by mouth) medications within 2 hours before or after you take psyllium. Bulk-forming laxatives can make it harder for your body to absorb other medications, possibly making them less effective.

Avoid breathing in the dust from psyllium powder when mixing. Inhaling psyllium dust may cause an allergic reaction.

If you take psyllium as part of a cholesterol-lowering treatment plan, avoid eating foods that are high in fat or cholesterol. Your treatment will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Laxmar Orange (psyllium) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using psyllium and call your doctor at once if you have a serious side effect such as:

choking or trouble swallowing;

severe stomach pain, cramping, nausea or vomiting;

constipation that lasts longer than 7 days;

rectal bleeding; or

itchy skin rash.

Less serious side effects may include:

bloating; or

minor change in your bowel habits.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Laxmar Orange (psyllium)?

Tell your doctor about all other medications you use, especially:

a blood thinner such as warfarin (Coumadin, Jantoven); or

demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with psyllium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Laxmar Orange resources Laxmar Orange Side Effects (in more detail) Laxmar Orange Use in Pregnancy & Breastfeeding Laxmar Orange Drug Interactions Laxmar Orange Support Group 0 Reviews for Laxmar Orange - Add your own review/rating Konsyl Powder MedFacts Consumer Leaflet (Wolters Kluwer) Metamucil MedFacts Consumer Leaflet (Wolters Kluwer) Compare Laxmar Orange with other medications Constipation Irritable Bowel Syndrome Where can I get more information? Your pharmacist can provide more information about psyllium.

See also: Laxmar Orange side effects (in more detail)


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Fiberall


Generic Name: psyllium (SIL ee um)
Brand Names: Fiberall, Hydrocil, Konsyl, Konsyl Orange Sugar-free, Konsyl-D, Konsyl-Orange, Laxmar, Laxmar Orange, Laxmar Sugar Free, Metamucil, Metamucil Berry Burst Smooth Texture Sugar Free, Metamucil Orange Coarse Milled Original Texture, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Original Texture Regular, Metamucil Pink Lemonade Smooth Texture Sugar-Free, Metamucil Unflavored Coarse Milled Original Texture, Metamucil Unflavored Smooth Texture Sugar Free, Natural Fiber Therapy, Perdiem Fiber Powder, Reguloid

What is Fiberall (psyllium)?

Psyllium is a bulk-forming fiber laxative. Psyllium works by absorbing liquid in the intestines and swelling to create a softer, bulky stool that is easier to pass.

Psyllium is used to treat occasional constipation or bowel irregularity. Psyllium may also be used to treat diarrhea and may help lower cholesterol when used together with a diet low in cholesterol and saturated fat.

Psyllium may also be used for purposes not listed in this product guide.

What is the most important information I should know about Fiberall (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have trouble swallowing, a sudden change in bowel habits that lasts longer than 2 weeks, severe nausea, vomiting, or stomach pain, or if you have ever had a skin rash while taking psyllium.

Also talk with your doctor before using psyllium if you have a colostomy or ileostomy, rectal bleeding, or a blockage in your intestines.

Stop using psyllium and call your doctor at once if you have choking or trouble swallowing, severe stomach pain or cramping, nausea or vomiting, constipation that lasts longer than 7 days, rectal bleeding, or itchy skin rash. Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. What should I discuss with my healthcare provider before taking Fiberall (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have:

trouble swallowing;

a sudden change in bowel habits that lasts longer than 2 weeks;

severe nausea, vomiting, or stomach pain; or

if you have ever had a skin rash while taking psyllium.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

a colostomy or ileostomy;

rectal bleeding; or

a blockage in your intestines.

Psyllium products may contain sugar, sodium, or artificial sweeteners. This may be of concern to you if you have diabetes, high blood pressure, or phenylketonuria (PKU). Check the product label if you have any of these conditions.

Psyllium is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether psyllium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Fiberall (psyllium)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take psyllium with a full glass (at least 8 ounces) of water or another liquid. Taking psyllium without enough liquid may cause it to swell in your throat and cause choking. Drinking plenty of fluids each day while you are taking psyllium will also help improve bowel regularity.

The psyllium wafer must be chewed before you swallow it.

Do not swallow psyllium powder dry. It must be mixed with liquid. Place the psyllium powder into an empty glass and add at least 8 ounces of water or other liquid such as fruit juice. Stir this mixture and drink all of it right away.

If the powder and liquid mixture is too thick, add more liquid. After drinking the entire mixture, add a little more liquid to the same glass, swirl gently and drink right away to make sure you get the entire dose of psyllium.

Psyllium may be only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

It may take up to 3 days of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 or 3 days of treatment.

Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Since psyllium is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using psyllium.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and stomach pain. Using a laxative too often or for too long may cause severe medical problems involving your intestines.

What should I avoid while taking Fiberall (psyllium)?

Avoid taking other oral (by mouth) medications within 2 hours before or after you take psyllium. Bulk-forming laxatives can make it harder for your body to absorb other medications, possibly making them less effective.

Avoid breathing in the dust from psyllium powder when mixing. Inhaling psyllium dust may cause an allergic reaction.

If you take psyllium as part of a cholesterol-lowering treatment plan, avoid eating foods that are high in fat or cholesterol. Your treatment will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Fiberall (psyllium) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using psyllium and call your doctor at once if you have a serious side effect such as:

choking or trouble swallowing;

severe stomach pain, cramping, nausea or vomiting;

constipation that lasts longer than 7 days;

rectal bleeding; or

itchy skin rash.

Less serious side effects may include:

bloating; or

minor change in your bowel habits.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Fiberall (psyllium)?

Tell your doctor about all other medications you use, especially:

a blood thinner such as warfarin (Coumadin, Jantoven); or

demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with psyllium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Fiberall resources Fiberall Side Effects (in more detail) Fiberall Use in Pregnancy & Breastfeeding Fiberall Drug Interactions Fiberall Support Group 0 Reviews for Fiberall - Add your own review/rating Konsyl Powder MedFacts Consumer Leaflet (Wolters Kluwer) Metamucil MedFacts Consumer Leaflet (Wolters Kluwer) Compare Fiberall with other medications Constipation Dietary Fiber Supplementation Irritable Bowel Syndrome Where can I get more information? Your pharmacist can provide more information about psyllium.

See also: Fiberall side effects (in more detail)


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Metamucil Orange Smooth Texture


Generic Name: psyllium (SIL ee um)
Brand Names: Fiberall, Hydrocil, Konsyl, Konsyl Orange Sugar-free, Konsyl-D, Konsyl-Orange, Laxmar, Laxmar Orange, Laxmar Sugar Free, Metamucil, Metamucil Berry Burst Smooth Texture Sugar Free, Metamucil Orange Coarse Milled Original Texture, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Original Texture Regular, Metamucil Pink Lemonade Smooth Texture Sugar-Free, Metamucil Unflavored Coarse Milled Original Texture, Metamucil Unflavored Smooth Texture Sugar Free, Natural Fiber Therapy, Perdiem Fiber Powder, Reguloid

What is Metamucil Orange Smooth Texture (psyllium)?

Psyllium is a bulk-forming fiber laxative. Psyllium works by absorbing liquid in the intestines and swelling to create a softer, bulky stool that is easier to pass.

Psyllium is used to treat occasional constipation or bowel irregularity. Psyllium may also be used to treat diarrhea and may help lower cholesterol when used together with a diet low in cholesterol and saturated fat.

Psyllium may also be used for purposes not listed in this product guide.

What is the most important information I should know about Metamucil Orange Smooth Texture (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have trouble swallowing, a sudden change in bowel habits that lasts longer than 2 weeks, severe nausea, vomiting, or stomach pain, or if you have ever had a skin rash while taking psyllium.

Also talk with your doctor before using psyllium if you have a colostomy or ileostomy, rectal bleeding, or a blockage in your intestines.

Stop using psyllium and call your doctor at once if you have choking or trouble swallowing, severe stomach pain or cramping, nausea or vomiting, constipation that lasts longer than 7 days, rectal bleeding, or itchy skin rash. Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. What should I discuss with my healthcare provider before taking Metamucil Orange Smooth Texture (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have:

trouble swallowing;

a sudden change in bowel habits that lasts longer than 2 weeks;

severe nausea, vomiting, or stomach pain; or

if you have ever had a skin rash while taking psyllium.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

a colostomy or ileostomy;

rectal bleeding; or

a blockage in your intestines.

Psyllium products may contain sugar, sodium, or artificial sweeteners. This may be of concern to you if you have diabetes, high blood pressure, or phenylketonuria (PKU). Check the product label if you have any of these conditions.

Psyllium is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether psyllium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Metamucil Orange Smooth Texture (psyllium)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take psyllium with a full glass (at least 8 ounces) of water or another liquid. Taking psyllium without enough liquid may cause it to swell in your throat and cause choking. Drinking plenty of fluids each day while you are taking psyllium will also help improve bowel regularity.

The psyllium wafer must be chewed before you swallow it.

Do not swallow psyllium powder dry. It must be mixed with liquid. Place the psyllium powder into an empty glass and add at least 8 ounces of water or other liquid such as fruit juice. Stir this mixture and drink all of it right away.

If the powder and liquid mixture is too thick, add more liquid. After drinking the entire mixture, add a little more liquid to the same glass, swirl gently and drink right away to make sure you get the entire dose of psyllium.

Psyllium may be only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

It may take up to 3 days of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 or 3 days of treatment.

Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Since psyllium is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using psyllium.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and stomach pain. Using a laxative too often or for too long may cause severe medical problems involving your intestines.

What should I avoid while taking Metamucil Orange Smooth Texture (psyllium)?

Avoid taking other oral (by mouth) medications within 2 hours before or after you take psyllium. Bulk-forming laxatives can make it harder for your body to absorb other medications, possibly making them less effective.

Avoid breathing in the dust from psyllium powder when mixing. Inhaling psyllium dust may cause an allergic reaction.

If you take psyllium as part of a cholesterol-lowering treatment plan, avoid eating foods that are high in fat or cholesterol. Your treatment will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Metamucil Orange Smooth Texture (psyllium) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using psyllium and call your doctor at once if you have a serious side effect such as:

choking or trouble swallowing;

severe stomach pain, cramping, nausea or vomiting;

constipation that lasts longer than 7 days;

rectal bleeding; or

itchy skin rash.

Less serious side effects may include:

bloating; or

minor change in your bowel habits.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Metamucil Orange Smooth Texture (psyllium)?

Tell your doctor about all other medications you use, especially:

a blood thinner such as warfarin (Coumadin, Jantoven); or

demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with psyllium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Metamucil Orange Smooth Texture resources Metamucil Orange Smooth Texture Side Effects (in more detail) Metamucil Orange Smooth Texture Use in Pregnancy & Breastfeeding Metamucil Orange Smooth Texture Drug Interactions 0 Reviews for Metamucil Orange Smooth Texture - Add your own review/rating Konsyl Powder MedFacts Consumer Leaflet (Wolters Kluwer) Metamucil MedFacts Consumer Leaflet (Wolters Kluwer) Compare Metamucil Orange Smooth Texture with other medications Constipation Dietary Fiber Supplementation Irritable Bowel Syndrome Where can I get more information? Your pharmacist can provide more information about psyllium.

See also: Metamucil Orange Smooth Texture side effects (in more detail)


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Perdiem Fiber Powder


Generic Name: psyllium (SIL ee um)
Brand Names: Fiberall, Hydrocil, Konsyl, Konsyl Orange Sugar-free, Konsyl-D, Konsyl-Orange, Laxmar, Laxmar Orange, Laxmar Sugar Free, Metamucil, Metamucil Berry Burst Smooth Texture Sugar Free, Metamucil Orange Coarse Milled Original Texture, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Original Texture Regular, Metamucil Pink Lemonade Smooth Texture Sugar-Free, Metamucil Unflavored Coarse Milled Original Texture, Metamucil Unflavored Smooth Texture Sugar Free, Natural Fiber Therapy, Perdiem Fiber Powder, Reguloid

What is Perdiem Fiber Powder (psyllium)?

Psyllium is a bulk-forming fiber laxative. Psyllium works by absorbing liquid in the intestines and swelling to create a softer, bulky stool that is easier to pass.

Psyllium is used to treat occasional constipation or bowel irregularity. Psyllium may also be used to treat diarrhea and may help lower cholesterol when used together with a diet low in cholesterol and saturated fat.

Psyllium may also be used for purposes not listed in this product guide.

What is the most important information I should know about Perdiem Fiber Powder (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have trouble swallowing, a sudden change in bowel habits that lasts longer than 2 weeks, severe nausea, vomiting, or stomach pain, or if you have ever had a skin rash while taking psyllium.

Also talk with your doctor before using psyllium if you have a colostomy or ileostomy, rectal bleeding, or a blockage in your intestines.

Stop using psyllium and call your doctor at once if you have choking or trouble swallowing, severe stomach pain or cramping, nausea or vomiting, constipation that lasts longer than 7 days, rectal bleeding, or itchy skin rash. Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. What should I discuss with my healthcare provider before taking Perdiem Fiber Powder (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have:

trouble swallowing;

a sudden change in bowel habits that lasts longer than 2 weeks;

severe nausea, vomiting, or stomach pain; or

if you have ever had a skin rash while taking psyllium.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

a colostomy or ileostomy;

rectal bleeding; or

a blockage in your intestines.

Psyllium products may contain sugar, sodium, or artificial sweeteners. This may be of concern to you if you have diabetes, high blood pressure, or phenylketonuria (PKU). Check the product label if you have any of these conditions.

Psyllium is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether psyllium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Perdiem Fiber Powder (psyllium)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take psyllium with a full glass (at least 8 ounces) of water or another liquid. Taking psyllium without enough liquid may cause it to swell in your throat and cause choking. Drinking plenty of fluids each day while you are taking psyllium will also help improve bowel regularity.

The psyllium wafer must be chewed before you swallow it.

Do not swallow psyllium powder dry. It must be mixed with liquid. Place the psyllium powder into an empty glass and add at least 8 ounces of water or other liquid such as fruit juice. Stir this mixture and drink all of it right away.

If the powder and liquid mixture is too thick, add more liquid. After drinking the entire mixture, add a little more liquid to the same glass, swirl gently and drink right away to make sure you get the entire dose of psyllium.

Psyllium may be only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

It may take up to 3 days of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 or 3 days of treatment.

Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Since psyllium is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using psyllium.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and stomach pain. Using a laxative too often or for too long may cause severe medical problems involving your intestines.

What should I avoid while taking Perdiem Fiber Powder (psyllium)?

Avoid taking other oral (by mouth) medications within 2 hours before or after you take psyllium. Bulk-forming laxatives can make it harder for your body to absorb other medications, possibly making them less effective.

Avoid breathing in the dust from psyllium powder when mixing. Inhaling psyllium dust may cause an allergic reaction.

If you take psyllium as part of a cholesterol-lowering treatment plan, avoid eating foods that are high in fat or cholesterol. Your treatment will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Perdiem Fiber Powder (psyllium) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using psyllium and call your doctor at once if you have a serious side effect such as:

choking or trouble swallowing;

severe stomach pain, cramping, nausea or vomiting;

constipation that lasts longer than 7 days;

rectal bleeding; or

itchy skin rash.

Less serious side effects may include:

bloating; or

minor change in your bowel habits.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Perdiem Fiber Powder (psyllium)?

Tell your doctor about all other medications you use, especially:

a blood thinner such as warfarin (Coumadin, Jantoven); or

demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with psyllium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Perdiem Fiber Powder resources Perdiem Fiber Powder Side Effects (in more detail) Perdiem Fiber Powder Use in Pregnancy & Breastfeeding Perdiem Fiber Powder Drug Interactions Perdiem Fiber Powder Support Group 0 Reviews for Perdiem Fiber - Add your own review/rating Konsyl Powder MedFacts Consumer Leaflet (Wolters Kluwer) Metamucil MedFacts Consumer Leaflet (Wolters Kluwer) Compare Perdiem Fiber Powder with other medications Constipation Dietary Fiber Supplementation Irritable Bowel Syndrome Where can I get more information? Your pharmacist can provide more information about psyllium.

See also: Perdiem Fiber side effects (in more detail)


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Metamucil Orange Smooth Texture Sugar Free


Generic Name: psyllium (SIL ee um)
Brand Names: Fiberall, Hydrocil, Konsyl, Konsyl Orange Sugar-free, Konsyl-D, Konsyl-Orange, Laxmar, Laxmar Orange, Laxmar Sugar Free, Metamucil, Metamucil Berry Burst Smooth Texture Sugar Free, Metamucil Orange Coarse Milled Original Texture, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Original Texture Regular, Metamucil Pink Lemonade Smooth Texture Sugar-Free, Metamucil Unflavored Coarse Milled Original Texture, Metamucil Unflavored Smooth Texture Sugar Free, Natural Fiber Therapy, Perdiem Fiber Powder, Reguloid

What is Metamucil Orange Smooth Texture Sugar Free (psyllium)?

Psyllium is a bulk-forming fiber laxative. Psyllium works by absorbing liquid in the intestines and swelling to create a softer, bulky stool that is easier to pass.

Psyllium is used to treat occasional constipation or bowel irregularity. Psyllium may also be used to treat diarrhea and may help lower cholesterol when used together with a diet low in cholesterol and saturated fat.

Psyllium may also be used for purposes not listed in this product guide.

What is the most important information I should know about Metamucil Orange Smooth Texture Sugar Free (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have trouble swallowing, a sudden change in bowel habits that lasts longer than 2 weeks, severe nausea, vomiting, or stomach pain, or if you have ever had a skin rash while taking psyllium.

Also talk with your doctor before using psyllium if you have a colostomy or ileostomy, rectal bleeding, or a blockage in your intestines.

Stop using psyllium and call your doctor at once if you have choking or trouble swallowing, severe stomach pain or cramping, nausea or vomiting, constipation that lasts longer than 7 days, rectal bleeding, or itchy skin rash. Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. What should I discuss with my healthcare provider before taking Metamucil Orange Smooth Texture Sugar Free (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have:

trouble swallowing;

a sudden change in bowel habits that lasts longer than 2 weeks;

severe nausea, vomiting, or stomach pain; or

if you have ever had a skin rash while taking psyllium.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

a colostomy or ileostomy;

rectal bleeding; or

a blockage in your intestines.

Psyllium products may contain sugar, sodium, or artificial sweeteners. This may be of concern to you if you have diabetes, high blood pressure, or phenylketonuria (PKU). Check the product label if you have any of these conditions.

Psyllium is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether psyllium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Metamucil Orange Smooth Texture Sugar Free (psyllium)?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Take psyllium with a full glass (at least 8 ounces) of water or another liquid. Taking psyllium without enough liquid may cause it to swell in your throat and cause choking. Drinking plenty of fluids each day while you are taking psyllium will also help improve bowel regularity.

The psyllium wafer must be chewed before you swallow it.

Do not swallow psyllium powder dry. It must be mixed with liquid. Place the psyllium powder into an empty glass and add at least 8 ounces of water or other liquid such as fruit juice. Stir this mixture and drink all of it right away.

If the powder and liquid mixture is too thick, add more liquid. After drinking the entire mixture, add a little more liquid to the same glass, swirl gently and drink right away to make sure you get the entire dose of psyllium.

Psyllium may be only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

It may take up to 3 days of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 or 3 days of treatment.

Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. Store at room temperature away from moisture and heat. What happens if I miss a dose?

Since psyllium is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using psyllium.

What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, and stomach pain. Using a laxative too often or for too long may cause severe medical problems involving your intestines.

What should I avoid while taking Metamucil Orange Smooth Texture Sugar Free (psyllium)?

Avoid taking other oral (by mouth) medications within 2 hours before or after you take psyllium. Bulk-forming laxatives can make it harder for your body to absorb other medications, possibly making them less effective.

Avoid breathing in the dust from psyllium powder when mixing. Inhaling psyllium dust may cause an allergic reaction.

If you take psyllium as part of a cholesterol-lowering treatment plan, avoid eating foods that are high in fat or cholesterol. Your treatment will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Metamucil Orange Smooth Texture Sugar Free (psyllium) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using psyllium and call your doctor at once if you have a serious side effect such as:

choking or trouble swallowing;

severe stomach pain, cramping, nausea or vomiting;

constipation that lasts longer than 7 days;

rectal bleeding; or

itchy skin rash.

Less serious side effects may include:

bloating; or

minor change in your bowel habits.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Metamucil Orange Smooth Texture Sugar Free (psyllium)?

Tell your doctor about all other medications you use, especially:

a blood thinner such as warfarin (Coumadin, Jantoven); or

demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and other drugs may interact with psyllium. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Metamucil Orange Smooth Texture Sugar Free resources Metamucil Orange Smooth Texture Sugar Free Side Effects (in more detail) Metamucil Orange Smooth Texture Sugar Free Use in Pregnancy & Breastfeeding Metamucil Orange Smooth Texture Sugar Free Drug Interactions 0 Reviews for Metamucil Orange Smooth Texture Sugar Free - Add your own review/rating Konsyl Powder MedFacts Consumer Leaflet (Wolters Kluwer) Metamucil MedFacts Consumer Leaflet (Wolters Kluwer) Compare Metamucil Orange Smooth Texture Sugar Free with other medications Constipation Dietary Fiber Supplementation Irritable Bowel Syndrome Where can I get more information? Your pharmacist can provide more information about psyllium.

See also: Metamucil Orange Smooth Texture Sugar Free side effects (in more detail)


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MabCampath 30mg / ml concentrate for solution for infusion


MabCampath 30 mg/ml concentrate for solution for infusion

Alemtuzumab

Read all of this leaflet carefully before you start taking this medicine Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. In this leaflet: 1. What MabCampath is and what it is used for 2. Before you are given MabCampath 3. How MabCampath is used 4. Possible side effects 5. How to store MabCampath 6. Further information What Mabcampath Is And What It Is Used For

MabCampath is used to treat patients with chronic lymphocytic leukaemia (CLL), a cancer of the lymphocytes (a type of white blood cell). It is used in patients for whom treatment combinations including fludarabine (another medicine used in leukaemia) are not appropriate.

The active substance in MabCampath, alemtuzumab, is a monoclonal antibody. A monoclonal antibody is an antibody (a type of protein) that has been designed to recognise and bind to a specific structure (called an antigen) that is found in certain cells in the body. In CLL, too many lymphocytes are produced. Alemtuzumab has been designed to bind to a glycoprotein (a protein that is coated with sugar molecules) that is found on the surface of lymphocytes. As a result of this binding, the lymphocytes die, and this helps to control the CLL.

Before You Are Given Mabcampath Do not use MabCampath if you: are allergic to alemtuzumab or to proteins of a similar origin or to any of the other ingredients of MabCampath (see section 6 “Further Information”). Your doctor will inform you accordingly have an infection have HIV have an active second malignancy are pregnant (see also “Pregnancy”). Take special care with MabCampath:

When you first receive MabCampath, you may experience side effects soon after the first infusions (see section 4 “Possible side effects”). These effects will gradually reduce as treatment is continued.

You may also be given steroids, antihistamines or analgesics (treatment for fever) to help to reduce some of the side effects.

The dosage of MabCampath will not be increased until the effects are reduced.

MabCampath treatment may reduce your natural resistance to infections

antibiotics and antivirals may be given to provide you with extra protection.

You will be examined for symptoms of a certain type of viral infection called CMV (cytomegalovirus) during your MabCampath therapy and for at least 2 months afterwards.

Your doctor will monitor you carefully if you have heart disease or chest pains and/or you are receiving treatment to reduce high blood pressure, as MabCampath may make these conditions worse.
Patients with these conditions may be at higher risk of a heart attack. have been treated in the past with chemotherapies or general medications that have a high risk of causing heart damage, your doctor may wish to monitor your cardiac function (ECG, heart rate, body weight) while receiving MabCampath. have other side effects, most often blood disorders from taking MabCampath.
Your doctor will be monitoring the effects of treatment and your progress carefully by examining you and by taking blood samples for analysis on a regular basis. are over 65 years of age as you may be more intolerant to the medicine than other patients.

You may experience an allergic or hypersensitivity reaction to MabCampath solution, especially against the protein contained in it, while the infusion is given to you. Your doctor will treat you for this, if this happens.

Because of the potential for a fatal reaction to transfusion of any blood products following treatment with MabCampath, it is recommended that you speak to your doctor regarding the irradiation of blood products prior to receiving the transfusion.

MabCampath is not recommended in children below 17 years of age or in patients who have kidney or liver disorders.

Taking other medicines

You should inform your doctor if you are taking or have recently taken any other medicines, even those not prescribed.

In particular, you should not be given MabCampath within 3 weeks of taking any other anti-cancer agents.

Also, you should not be vaccinated with live viral vaccines during treatment and for at least 12 months after you have finished your treatment. Speak to your doctor before receiving any vaccinations.

Pregnancy

MabCampath must not be administered to patients who are pregnant, therefore if you:

are pregnant or you think you may be pregnant, you should tell your doctor immediately. are of childbearing potential, then you should avoid becoming pregnant by using effective contraceptive methods before you start treatment, during treatment and for 6 months after treatment. Breast-feeding

You should stop breast-feeding when you start your treatment and you should not begin breast-feeding again until at least 4 weeks after you have finished your treatment and you have consulted your doctor on the matter.

Driving or using machines

No studies of the effects of MabCampath on the ability to drive and use machines have been performed. However you should be cautious as confusion and sleepiness have been seen. You should ask your doctor for advice.

How Mabcampath Is Used

MabCampath goes into one of your veins via a drip (see also ‘information intended for medical or healthcare professionals’).

Each time you are given MabCampath, it will take about 2 hours for all the solution to enter your blood.

MabCampath treatment may continue for up to 12 weeks depending on your progress.

During the first week, your doctor will increase the dose of MabCampath slowly to reduce the possibility of you having side effects and to allow your body to tolerate MabCampath better.

If you experience early side effects the initial smaller doses may be repeated until the effects go away or reduce. The doctor will carefully monitor you and decide what are the appropriate amounts of MabCampath to give during your whole treatment period.

If more MabCampath is given than recommended

Your doctor will treat you, as appropriate, if you have any side effects.

Possible Side Effects

Like all medicines, MabCampath can cause side effects, although not everybody gets them.

Your doctor may give you other medicines or change your dosage to help to reduce any side effects (see section 2 “Take Special care”).

Serious side effects, including difficulty in breathing, inflammation of the lungs, extreme shortness of breath, fainting, heart attack, autoimmune phenomena, low red blood cell and low blood platelet levels, infections, bleeding in the brain (intracranial haemorrhage) have occurred with fatal outcome. Tell your doctor immediately if you experience any of these side effects.

In addition, testing indicating the presence of antibodies that may destroy red blood cells (Coombs test) has been reported.

Very common side effects (seen in at least 1 in every 10 patients treated in clinical trials):

Usually one or more of these effects happen during the first week after the start of treatment:

fever, shivering/chills, sweating, nausea (feeling sick), vomiting, low blood pressure, low white/red blood cell levels, infections including pneumonia and blood poisoning, irritation and/or blistering of the mouth region, low blood platelet levels, tiredness, rash, itching, red raised lesions on the skin, shortness of breath, headache, diarrhoea and loss of appetite.

They are usually only mild or moderate problems and they gradually diminish during the course of treatment.

Common side effects (affects 1 to 10 patients in every 100 patients treated in clinical trials):

high blood pressure, fast or slow heart rate, feeling your heart racing, blood vessel spasm becoming red in the face, bruising of the skin taste changes decreased sense of touch dizziness, sensation of spinning, fainting, shaking or trembling movements, feeling restless eye inflammation (e.g. conjunctivitis) pins and needles or burning sensation of the skin abnormal liver function, constipation, indigestion, passing abdominal gas inflammation, irritation and/or tightness of the lungs, throat and/or sinuses, too little oxygen reaching the body organs, coughing, coughing up of blood abdominal bleeding (e.g. in the stomach and intestine) injection site reactions including redness, swelling, pain, bruising, inflammation generally feeling unwell, weakness, pain in various parts of the body (muscle, back, chest, bones, joints, stomach and intestine) weight loss, dehydration, thirst, swelling of the lower legs, temperature change sensation, low calcium or sodium blood levels flu-like symptoms abscess, skin redness or allergic skin reaction, blistering of the skin confusion, anxiety, depression, sleeplessness

Uncommon side effects (affects 1 to 10 in every patients in 1,000 patients treated in clinical trials):

bone marrow disorders heart disorders (heart stopping, heart attack, heart congestion, irregular heart rate) blood disorders (abnormal clotting, decreased protein, low potassium levels) high blood sugar, worsening diabetes bleeding and inflammation of the gums, blisters on the tongue, nosebleeds fluid in the lungs, difficulty breathing, harsh sound when breathing, runny nose, abnormal findings in the lungs, lymph gland disorders nervousness, abnormal thinking swelling around the eye ringing sound in the ears, deafness hiccups, burping hoarseness abnormal kidney function paralysis of the small bowel impotence unsteadiness, increased muscle tone unusual increased or altered sensitivity to touch’ abnormal sensation/feeling or movement pain when urinating, decreases in urine flow, increased frequency in urination, blood in urine, incontinence tumour lysis syndrome (a metabolic disorder, which may begin with pains in the side and blood in the urine)

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or your pharmacist.

How To Store Mabcampath

Keep out of the reach and sight of children.

Do not use MabCampath after the expiry date (EXP) which is stated on the outer carton and the vial label.

Store in a refrigerator (2°C-8°C).

Do not freeze.

Store in the original packaging in order to protect from light.

Medicines should not be disposed of via wastewater or household waste. Your healthcare professional will dispose of medicines no longer required. These measures will help protect the environment.

Further Information What MabCampath contains

The active substance is alemtuzumab.

One ml contains 30 mg of alemtuzumab. Each vial contains 30 mg of alemtuzumab.

The other ingredients are disodium edetate, polysorbate 80, potassium chloride, potassium dihydrogen phosphate, sodium chloride, dibasic sodium phosphate and water for injections.

What MabCampath looks like and contents of the pack

MabCampath is a concentrate for solution for infusion that comes in a glass vial.

Each pack of MabCampath contains 3 vials.

Marketing Authorisation Holder Genzyme Europe BV Gooimeer 10 1411 DD Naarden Netherlands Manufacturer Genzyme Ltd. 37 Hollands Road Haverhill Suffolk CB9 8PU United Kingdom Genzyme Ireland Limited. IDA Industrial Park Old Kilmeaden Road Waterford Ireland Bayer Schering Pharma AG M?llerstrasse 178 D-13342 Berlin Germany

For any information about this medicine, please contact the local representative of the Marketing Authorisation Holder.

United Kingdom/Ireland Genzyme Therapeutics United Kingdom Tel: +44 1865 405200

This leaflet was last approved in 11/2009

Detailed information on this medicine is available on the European Medicines Agency (EMEA) web site: http://www.emea.europa.eu.


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Syllact


Generic Name: psyllium (SIL ee um)
Brand Names: Fiberall, Genfiber, Hydrocil, Konsyl, Konsyl Orange Sugar-free, Konsyl-D, Konsyl-Orange, Laxmar, Laxmar Orange, Laxmar Sugar Free, Metamucil, Metamucil Berry Burst Smooth Texture Sugar Free, Metamucil Orange Coarse Milled Original Texture, Metamucil Orange Smooth Texture, Metamucil Orange Smooth Texture Sugar Free, Metamucil Unflavored Coarse Milled Original Texture, Metamucil Unflavored Smooth Texture Sugar Free, Natural Fiber Therapy, Perdiem Fiber Powder, Reguloid, V-Lax

What is Syllact (psyllium)?

Psyllium is a bulk-forming fiber laxative. Psyllium works by absorbing liquid in the intestines and swelling to create a softer, bulky stool that is easier to pass.

Psyllium is used to treat occasional constipation or bowel irregularity. Psyllium may also be used to treat diarrhea and may help lower cholesterol when used together with a diet low in cholesterol and saturated fat.

Psyllium may also be used for other purposes not listed in this product guide.

What is the most important information I should know about Syllact (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have trouble swallowing, a sudden change in bowel habits that lasts longer than 2 weeks, severe nausea, vomiting, or stomach pain, or if you have ever had a skin rash while taking psyllium.

Also talk with your doctor before using psyllium if you have a colostomy or ileostomy, rectal bleeding, or a blockage in your intestines.

Stop using psyllium and call your doctor at once if you have choking or trouble swallowing, severe stomach pain or cramping, nausea or vomiting, constipation that lasts longer than 7 days, rectal bleeding, or itchy skin rash. Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. What should I discuss with my healthcare provider before taking Syllact (psyllium)? Laxatives may be habit-forming if they are used too often or for too long. This can lead to damage of intestinal nerves or muscle tissues. Do not take psyllium for longer than directed on the label or prescribed by your doctor. You should not take this product if you are allergic to psyllium, or if you have:

trouble swallowing;

a sudden change in bowel habits that lasts longer than 2 weeks;

severe nausea, vomiting, or stomach pain; or

if you have ever had a skin rash while taking psyllium.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this product. Before you take psyllium, tell your doctor if you have:

a colostomy or ileostomy;

rectal bleeding; or

a blockage in your intestines.

Psyllium products may contain sugar, sodium, or artificial sweeteners. This may be of concern to you if you have diabetes, high blood pressure, or phenylketonuria (PKU). Check the product label if you have any of these conditions.

FDA pregnancy category B. Psyllium is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether psyllium passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. How should I take Syllact (psyllium)?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Psyllium is intended to be used for a short time only.

Take psyllium with a full glass (at least 8 ounces) of water or another liquid. Taking psyllium without enough liquid may cause it to swell in your throat and cause choking. Drinking plenty of fluids each day while you are taking psyllium will also help improve bowel regularity.

The psyllium wafer must be chewed before you swallow it.

Do not swallow psyllium powder dry. It must be mixed with liquid. Place the psyllium powder into an empty glass and add at least 8 ounces of water or other liquid such as fruit juice. Stir this mixture and drink all of it right away.

If the powder and liquid mixture is too thick, add more liquid. After drinking the entire mixture, add a little more liquid to the same glass, swirl gently and drink right away to make sure you get the entire dose of psyllium.

Psyllium may be only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

It may take up to 3 days of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 or 3 days of treatment.

Do not take psyllium for longer than 7 days in a row unless your doctor has told you to. Store psyllium at room temperature away from moisture and heat. What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, and stomach pain. Using a laxative too often or for too long may cause severe medical problems involving your intestines.

What should I avoid while taking Syllact (psyllium)?

Avoid taking other oral (by mouth) medications within 2 hours before or after you take psyllium. Bulk-forming laxatives can make it harder for your body to absorb other medications, possibly making them less effective.

Avoid breathing in the dust from psyllium powder when mixing. Inhaling psyllium dust may cause an allergic reaction.

If you take psyllium as part of a cholesterol-lowering treatment plan, avoid eating foods that are high in fat or cholesterol. Your treatment will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Syllact (psyllium) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using psyllium and call your doctor at once if you have a serious side effect such as:

choking or trouble swallowing;

severe stomach pain, cramping, nausea or vomiting;

constipation that lasts longer than 7 days;

rectal bleeding; or

itchy skin rash.

Less serious side effects may include:

bloating; or

minor change in your bowel habits.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Syllact (psyllium)?

Tell your doctor about all other medications you use, especially:

a blood thinner such as warfarin (Coumadin); or

demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap).

This list is not complete and there may be other drugs that can interact with psyllium. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Syllact resources Syllact Side Effects (in more detail) Syllact Use in Pregnancy & Breastfeeding Syllact Drug Interactions Syllact Support Group 0 Reviews for Syllact - Add your own review/rating Konsyl Powder MedFacts Consumer Leaflet (Wolters Kluwer) Metamucil MedFacts Consumer Leaflet (Wolters Kluwer) Compare Syllact with other medications Constipation Dietary Fiber Supplementation Irritable Bowel Syndrome Where can I get more information? Your pharmacist can provide more information about psyllium.

See also: Syllact side effects (in more detail)


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